Protein Alignment uex and CNNM3

DIOPT Version :10

• Sequence 1: NP_001104390.2
• Gene: uex / 5740320
• FlyBaseID: FBgn0262124
• Length: 834
• Species: Drosophila melanogaster
• Sequence 2: XP_047299869.1
• Gene: CNNM3 / 26505
• HGNCID: 104
• Length: 738
• Species: Homo sapiens
• Alignment Length: 737
• Identity: 254/737 - (34%)
• Similarity: 370/737 - (50%)
• Gaps: 100/737 - (13%)

  Fly    57 RIVGIRLEDETVE----TKNGIPTVLVDKEQQFRVFGSGLEENTAITFTNEKNDY----GGPCLK 113
            |::|..||::...    .:.|......|.....|:||.|        |.|....:    |..|.:
Human    32 RVLGFCLEEDGAAGAGWVRGGAARDTPDATFLLRLFGPG--------FANSSWSWVAPEGAGCRE 88

  Fly   114 PATDLFTPIEVSSNGFSALYSVKFPSFINEFFICAKTAEKTTNHSKAATTTPLEHQGNSDFLKIK 178
            .|..       .:..:.||..::.            .||....|| |.....:|..|.:
Human    89 EAAS-------PAGEWRALLRLRL------------RAEAVRPHS-ALLAVRVEPGGGA------ 127

  Fly   179 TFEPLIPVWLAIIIIVTCLGFSALFSGLNLGLMSMDRTELKILRNTGTEKEKKYASKIAPVRDQG 243
             .|...|.|...:.....|..:||..||.|..:::...|:::||.:|:|.|:..|.::.|.|...
Human   128 -AEEAAPPWALGLGAAGLLALAALARGLQLSALALAPAEVQVLRESGSEAERAAARRLEPARRWA 191

  Fly   244 NYLLCSILLGNVLVNSTFTILLDGLTS--GLFAVIFSTLAIVLFGEITPQAVCSRHGLAIGAKTI 306
            ...|.::||...|..:...:||.....  .:.||:.|...:.|.||:.|.||..|..||:..:.:
Human   192 GCALGALLLLASLAQAALAVLLYRAAGQRAVPAVLGSAGLVFLVGEVVPAAVSGRWTLALAPRAL 256

  Fly   307 LVTKTVMAITAPLSYPVSRILDKLLGEEIGNVYNRERLKELVRVTND-VNDLDKNEVNIISGALE 370
            .:::..:.:|.|::.||.::|:  |....|.:  |||:.||.|...| .:||.|.         .
Human   257 GLSRLAVLLTLPVALPVGQLLE--LAARPGRL--RERVLELARGGGDPYSDLSKG---------V 308

  Fly   371 LRKKTVADVMTHINDAFMLSLDALLDFETVSEIMNSGYSRIPVYDGDRKNIVTLLYIKDLAFVDT 435
            ||.:||.||:|.:.|.|||....:|||..::.||.||::|||||:.:|.|||.:||:|||||||.
Human   309 LRCRTVEDVLTPLEDCFMLDASTVLDFGVLASIMQSGHTRIPVYEEERSNIVDMLYLKDLAFVDP 373

  Fly   436 DDNTPLKTLCEFYQNPVHFVFEDYTLDIMFNQFKEGTIGHIAFVHRVNNEGDGDPFYETVGLVTL 500
            :|.|||.|:..||.:|:||||.|..||.:..:||.|. .|:|.|.:|||||:||||||.:|||||
Human   374 EDCTPLSTITRFYNHPLHFVFNDTKLDAVLEEFKRGK-SHLAIVQKVNNEGEGDPFYEVLGLVTL 437

  Fly   501 EDVIEELIQAEIVDETDVFVDNRTKTRRNRY-----KKADFSAFAERREVQTVRISPQLTLATFQ 560
            ||||||:|::||:||::.:.|...|.:....     :|.:||.|....:...|.|||||.|||.:
Human   438 EDVIEEIIRSEILDESEDYRDTVVKRKPASLMAPLKRKEEFSLFKVSDDEYKVTISPQLLLATQR 502

  Fly   561 YLSTAVDAFKKDVISELILRRLL-----NQDVFHNIKTKGKSKDDPSLYIFTQGKAVDFFVLILE 620
            :||..||.|....|||.:|..||     ||:|..:...:..:..    |::.:.:.||:|:|||:
Human   503 FLSREVDVFSPLRISEKVLLHLLKHPSVNQEVRFDESNRLATHH----YLYQRSQPVDYFILILQ 563

  Fly   621 GRVEVTIGKEALMFESGPFTYFGTQAL-VPNVVIDSPTQMGSLQSLNM-------DSKIRQSFVP 677
            |||||.||||.|.||:|.|||:|..|| ||:.|..||  :.|||.:..       |.....::.|
Human   564 GRVEVEIGKEGLKFENGAFTYYGVSALTVPSSVHQSP--VSSLQPIRHDLQPDPGDGTHSSAYCP 626

  Fly   678 DYSVRAISDVIYITIKRVLYLTAKKATLLEKSRKSGTFSSETFDDEV-----ERLLHSITENEKP 737
            ||:|||:||:..|.:.|:.||.|..||..:...:    |.|..|.:|     .|||...|.....
Human   627 DYTVRALSDLQLIKVTRLQYLNALLATRAQNLPQ----SPENTDLQVIPGSQTRLLGEKTTTAAG 687

  Fly   738 SCFAQNQSTRR---LSNRSINS 756
            .|    |...|   |..|:::|
Human   688 EC----QVVHRAWCLDLRAVSS 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	TlyC	187..>517	CDD:440865	135/332 (41%)
		CAP_ED	<604..>650	CDD:469590	27/46 (59%)
CNNM3	XP_047299869.1	COG3903	<13..299	CDD:443109	73/305 (24%)
		CBS_pair_CorC_HlyC_assoc	313..442	CDD:341366	74/129 (57%)
		CBS repeat	321..387	CDD:341366	35/65 (54%)
		CBS repeat	391..442	CDD:341366	32/51 (63%)