DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment uex and cnnm-4

DIOPT Version :9

Sequence 1:	NP_001104390.2	Gene:	uex / 5740320	FlyBaseID:	FBgn0262124	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001379128.1	Gene:	cnnm-4 / 182093	WormBaseID:	WBGene00007255	Length:	467	Species:	Caenorhabditis elegans

Alignment Length:	425	Identity:	118/425 - (27%)
Similarity:	202/425 - (47%)	Gaps:	58/425 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 NGFSALYSVKFPSF-----INEFFICAKTAEKTTNHSKAATTTPLEHQGNSDFLKIKTFEPLIPV 186
            :|....|.:|....     :...|.|       ||.........||.....|..::....||
Worm    63 SGVLVEYKIKISLLQSSDGVKHLFFC-------TNPKSVDIARMLEIPEGKDKTRVYFMMPL--- 117

  Fly   187 WLAIIIIVTCLGFSALFSGLNLGLMSMDRTELKILRNTGTEK-EKKYASKIAPVRDQGNYLLCSI 250
                  :|.|||.||.||||||.:||....:||:::.:.::| .|:.|..:..:|...|::|.:|
Worm   118 ------LVLCLGLSATFSGLNLAIMSFSINDLKLIQESDSDKLMKQRAMDVMRLRRNSNFVLVTI 176

  Fly   251 LLGNVLVNSTFTILLD------GLTSGLFAVIFSTLAIVLFGEITPQAVCSRHGLAIGAKTILVT 309
            :.||...|.:.|:|::      |....:|..:.||..:::|.||.|..:.:::.|||.::.....
Worm   177 IFGNCFCNISITLLMNYFAEFYGFGGFIFVELISTALLLIFTEILPSLIFTKNALAIASRLQYFV 241

  Fly   310 KTVMAITAPLSYPVSRILDKLLGEEIGNVYNRERLKELVRVTNDVNDLDKNE----------VNI 364
            ...|.||:|:|||::.:|:.:||:|     |.:....|......:::|:..|          :::
Worm   242 IFTMCITSPISYPLAMLLNIILGKE-----NADDSAPLDLDALQIDELEDEEAADGNNFHEMMSV 301

  Fly   365 ISGALELRKKTVADVMTHINDAFMLSLDALLDFETVSEIMNSGYSRIPVYDGDRKN-IVTLLYIK 428
            :...::||:|..:||||.|:...|.|....:....:.:....|:||:|||:|:.:| |..:|.|.
Worm   302 VKKTIKLREKLASDVMTEIDKVGMYSEHQQVTHSFLLDAYEQGHSRLPVYEGETRNKIRGVLNIT 366

  Fly   429 DLAFVDTDDNTPLKT-------LCEFYQNPVH-FVFEDYTLDIMFNQFKEGTIGHIAFVHR---V 482
            |:..:..|:.....|       |....:...| ||.:...::...::.::|.  .:|.|.|   |
Worm   367 DMMLLMDDEGRGSDTDLTLGTMLSVLEKRRKHCFVLDTMPVEHFMSELQQGC--PMAIVVRYKEV 429

  Fly   483 NNEGDGDPFYETVGLVTLEDVIEELIQAEIVDETD 517
            ::|.||...||..|:|||||.|||:: .||.||.|
Worm   430 DSEEDGTEIYEVCGIVTLEDCIEEIL-GEIFDEKD 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	DUF21	188..361	CDD:279876	53/179 (30%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	37/133 (28%)
		CAP_ED	<604..>650	CDD:294041
cnnm-4	NP_001379128.1	TlyC	111..>467	CDD:224173	108/370 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	O	PTHR12064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820