DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment uex and cnnm-2

DIOPT Version :9

Sequence 1:	NP_001104390.2	Gene:	uex / 5740320	FlyBaseID:	FBgn0262124	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001361958.1	Gene:	cnnm-2 / 181129	WormBaseID:	WBGene00019869	Length:	760	Species:	Caenorhabditis elegans

Alignment Length:	790	Identity:	246/790 - (31%)
Similarity:	380/790 - (48%)	Gaps:	155/790 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 IVGIRLEDETVETKN-------GIPTVLVDKEQQFRVFGSGLEENTAITFTNEKNDYGGPCLKPA 115
            :.|:|:|.: |:...       |...|..:.|....:||.|||....:|||:      ..|:.
Worm    29 VSGVRIESD-VDASGFLGYGDAGELLVEANTEVDLVIFGHGLENVEMVTFTD------SVCVT-- 84

  Fly   116 TDLFTPIEVSSNGF------SALYSVKFPSFINEFFICAKTAEKTTNHSKAATTTPLEHQG---- 170
                :...||.:.|      ..::...|.::...:.||.|:                |..|
Worm    85 ----SEFNVSESTFYIHKDMKIVFKYAFVAWPQPWRICLKS----------------ECHGLIQI 129

  Fly   171 NSDFLKIK----TFEPLIPVWLAIIIIVTCLGFSALFSGLNLGLMSMDRTELKILRNTGTEKEKK 231
            :.|...|:    |.|..:|||....|:......|||.|||.||||::...||.||..:|:::|||
Worm   130 DDDRTWIQAVQSTHETFMPVWAQCAILCLLFSISALCSGLTLGLMALTPQELSILMKSGSQREKK 194

  Fly   232 YASKIAPVRDQGNYLLCSILLGNVLVNSTFTILLDGLTSGLFAVIFSTLAIVLFGEITPQAVCSR 296
            :|:.|.|:|..||.|||::::.||:||:..|:|.|.|..||.|.:.||:.||:||||.||::|.:
Worm   195 HAAAIYPIRCHGNRLLCTVIIMNVIVNTGITLLFDDLAEGLIAFVASTVGIVVFGEILPQSICVK 259

  Fly   297 HGLAIGAKTILVTKTVMAITAPLSYPVSRILDKLLGEEIGNVYNRERLKELVRVT--NDVNDLDK 359
            :|||:||.||.:||..|.:..|:::|:.:||||..|.:| :|.||.|:.|::::.  ||..|:|.
Worm   260 YGLAVGANTIFITKFFMFLLFPITWPLGKILDKYAGVDI-DVVNRSRMVEMLKMNMENDACDIDL 323

  Fly   360 NEVNIISGALELRKKTVADVMTHINDAFMLSLDALLDFETVSEIMNSGYSRIPVYDGDRKN-IVT 423
            :.:.|..||:||.||:|.||||.|:|.||||.|.:|:.||:::|.:|||:||||::|:.:| :..
Worm   324 STLKIAIGAMELTKKSVRDVMTDIDDVFMLSEDQVLNAETMTKISDSGYTRIPVFEGNNRNKVKN 388

  Fly   424 LLYIKDLAFVDTDDNTPLKTLCEFYQNPVHFVFEDYTLDIMFNQFKEGTIGHIAFV--------H 480
            |||:.|||.:..|:|..:|.:..|.:..:..|.|...|..:.::||.|.. |:|.|        |
Worm   389 LLYVSDLALIGKDNNITVKAVARFNKRRLRIVDESMPLTALMDEFKLGDY-HLAMVAKATEVKKH 452

  Fly   481 RVNNEGDG--DPF-----------------------YETVGLVTLEDVIEELIQAEIVDETDVFV 520
            ......||  |.|                       ...|||:||||:.|||:||||.||||.:|
Worm   453 HHGKFADGTVDSFILKSMKLVEATMMPQVENPEDHPVTLVGLITLEDITEELLQAEITDETDCYV 517

  Fly   521 --DNRTKTRRNRYKKADFSAFAERREVQTVRISPQLTLATFQYLSTAVDAFKKDVISELILRRLL 583
              |.:.|.|.|..||:....|..  |.::.|:|..:...|.::|......|..           :
Worm   518 TDDAQKKRRTNTSKKSAAELFCS--EKKSERLSLHMLEMTEKWLLEKTPLFGN-----------M 569

  Fly   584 NQDVFHNIKTKG---------KSKDDP-SLYIFTQGKAVDFFVLILEGRVEVTIGKEALMFESGP 638
            |...|.|:..:.         |:...| :|.:|..|.....|:|||||:..:...::.|:||.||
Worm   570 NPKAFENLIQRNIREVLIVPPKNSTSPGTLNLFEAGVMSKRFLLILEGKATIRFNEKDLIFECGP 634

  Fly   639 FTYFGTQALVPNVVIDSPTQMGSLQSLNMDSKIRQS------FVPDYSVRAISDVIYITIKRVLY 697
            :|.|| :|:              |:.:.|....|:.      |:|||::.......::.|.....
Worm   635 WTCFG-EAI--------------LEKMEMCISDRKEPSTGFFFLPDYNLTVSGPCRFLQISTSSL 684

  Fly   698 LTAKKATLLEKSRKSGTFSSETFDDEVERLLHSITENEKPSCFAQNQSTRRLSNRSINSSPTNMN 762
            |.:.:.|...|..::...|. |.||:.                  ...||:.|  .::|||.:..
Worm   685 LHSLRITQFVKEIRTPKISI-TSDDDF------------------GSPTRKAS--ILDSSPNSRK 728

  Fly   763 RSPDFVYNSV 772
            ||...|.||:
Worm   729 RSSTSVMNSL 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	DUF21	188..361	CDD:279876	77/174 (44%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	50/155 (32%)
		CAP_ED	<604..>650	CDD:294041	17/45 (38%)
cnnm-2	NP_001361958.1	TlyC	154..>514	CDD:224173	149/361 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	162	1.000	Domainoid score	I2422
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	O	PTHR12064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.780