Protein Alignment uex and cnnm-3

DIOPT Version :9

• Sequence 1: NP_001104390.2
• Gene: uex / 5740320
• FlyBaseID: FBgn0262124
• Length: 834
• Species: Drosophila melanogaster
• Sequence 2: NP_001309670.1
• Gene: cnnm-3 / 180591
• WormBaseID: WBGene00016343
• Length: 797
• Species: Caenorhabditis elegans
• Alignment Length: 883
• Identity: 270/883 - (30%)
• Similarity: 428/883 - (48%)
• Gaps: 158/883 - (17%)

  Fly     5 FISFITIIIFANGINGTSVDTSNKLLLQKANDFNLSQNL---SSSRTRRTIANSFRIVGIRLEDE 66
            |:...|..:.::.:..|...||:|.||...:...|..::   |:|:......:..|:.|:|||..
 Worm    13 FLLTFTSPLSSSPVRSTDNSTSSKGLLNVNSSVILEPSILPSSASKPESLHLSKVRVSGLRLEAH 77

  Fly    67 TVETKNGI--------PTVLVDKEQQFRVFGSGLEENTAITFTNEKNDYGGPCLKPATDLF---- 119
            ...|:|.:        ..|:.:|..:..:||...::..|:|||.:     |.| |.....|
 Worm    78 ASSTENIVLGHNKKHNVVVVPNKNVRVVLFGQNFQDIGALTFTAD-----GSC-KDLAHFFEADF 136

  Fly   120 ---TPIEV-----------SSNGFSALYSVKFPSFINEFFICAKTAEKTTNHSKAATTTPLEHQG 170
               |||.|           |.:.|....|.||  :.|..|:..:      :.....||
 Worm   137 SSMTPIRVVVEMSFPKTTESKDSFKLCVSEKF--YANPQFVIVE------DPFTMVTT------- 186

  Fly   171 NSDFLKIKTFEPLIPVWLAIIIIVTCLGFSALFSGLNLGLMSMDRTELKILRNTGTEKEKKYASK 235
                 :|...:..:|.||:.|.::..|.||.||||||||||::...||::...:|||:||:.|.:
 Worm   187 -----EIPPVDEYMPKWLSWICLLILLCFSGLFSGLNLGLMTLSPYELQLYIASGTEQEKRDAGR 246

  Fly   236 IAPVRDQGNYLLCSILLGNVLVNSTFTILLDGLTSGLFAV-IFSTLAIVLFGEITPQAVCSRHGL 299
            |.|:|.:||.|||::|:|||:||...::|:|.|....||| :.:|..||:||||.|||:|.:.||
 Worm   247 ILPIRKKGNQLLCTLLIGNVVVNVGVSLLMDQLVGSGFAVLVAATSCIVVFGEIIPQALCVKLGL 311

  Fly   300 AIGAKTILVTKTVMAITAPLSYPVSRILDKLLGEEIGNVYNRERLKELVRVT-NDVNDLDKNEVN 363
            .|||:||.:|:.::.:..||::|:|::||..|.||:.....|.:|.|::::: ..:.....:|..
 Worm   312 PIGARTIPITQVLLFLMYPLTWPISKVLDIFLKEELTRSLERNKLVEMLKLSEKSIIGGQSDEFK 376

  Fly   364 IISGALELRKKTVADVMTHINDAFMLSLDALLDFETVSEIMNSGYSRIPVYDGDRKNIVTLLYIK 428
            ::.|||||..||||..||...|.|||.....|....|::|::.||:|||:|:.||||||.||::|
 Worm   377 MVLGALELYDKTVAHAMTRYEDIFMLPHTLTLGAGMVTQILDMGYTRIPIYENDRKNIVALLFVK 441

  Fly   429 DLAFVDTDDNTPLKTLCEFYQNPVHFVFEDYTLDIMFNQFKEGTIGHIAFVHRVNNEGDGDPFYE 493
            |||.:|.|||..:..:...|.:.|..|..|..|..|..:||.|.. |:|.|.|:..:.|.||.||
 Worm   442 DLALLDPDDNHNVMKIASIYNHEVRRVLVDMPLRNMLEEFKRGEY-HMALVERLVEQEDKDPIYE 505

  Fly   494 TVGLVTLEDVIEELIQAEIVDETDVFVDNRTKTRRNRYKKADFSAFAERREVQTVRISPQLTLAT 558
            ..||:||||:|||:||.||:||||...||..:.:|.|.:..|.|........:.. |:.|:...|
 Worm   506 LCGLITLEDIIEEIIQCEIIDETDAVCDNVHRKKRQRKRNHDMSQIVNTAHAKCA-INIQMLAVT 569

  Fly   559 FQYLSTAVDAFKKDVISELILRRLLNQDV-------FHNIKTKGKSKDDPSLYIFTQGKAVDFFV 616
            .|.:||....|..:.|...||.:|:.::.       |..:|..|..:..|:: :||:|:..:.|:
 Worm   570 IQVMSTCHKIFSSNYILPTILEKLIRKNCKKVETTQFSCLKEVGVVQPKPAV-LFTKGEFSNKFI 633

  Fly   617 LILEGRVEVTIGKEALMFESGPFTYFGTQAL--VPNVVIDSPTQMGSLQSLNMDSKIRQS---FV 676
            :||.||..||||||.:..|:|.:..|||:.|  :...:..|..|..|..:::::::|..:   |:
 Worm   634 MILSGRAVVTIGKEEMRLEAGAWHSFGTEVLDAMAEAIERSLNQSTSRSTVSLNTEITNNSIGFI 698

  Fly   677 PDYSVRAISDVIYITIKRVLYLTAKKATLLEKSRKSGTFSSETFDDEVERLLHSITENEKPSCFA 741
            ||:....:.:.::..|      ||  |.||
 Worm   699 PDFDTVILYECVFCEI------TA--ADLL----------------------------------- 720

  Fly   742 QNQSTRRLSNRSINSSPTNMNRSPDFVYNSVDEAIQDDTKLKNIKH-----------ADNVTTSI 795
                                     ..||| .:.:|::||::.::.           .|.|:|.|
 Worm   721 -------------------------LAYNS-SQIMQNNTKMQVVRSNSRISLIEEIPKDAVSTPI 759

  Fly   796 SLVAAELEDLHSGEQDTTAASMPLLPKLDDKFESKQSK 833
            ...:.:|..:..||      ::.||||..:...:||.|
 Worm   760 RNGSVKLRTVSEGE------TVHLLPKNMECHFNKQEK 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	DUF21	188..361	CDD:279876	74/174 (43%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	54/121 (45%)
		CAP_ED	<604..>650	CDD:294041	20/47 (43%)
cnnm-3	NP_001309670.1	DUF21	199..366	CDD:279876	74/166 (45%)
		CBS_pair	398..491	CDD:301603	40/93 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166491
Domainoid	1	1.000	228	1.000	Domainoid score	I1412
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1102
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		otm14380
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	O	PTHR12064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760