DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment uex and cnnm3

DIOPT Version :9

Sequence 1:	NP_001104390.2	Gene:	uex / 5740320	FlyBaseID:	FBgn0262124	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_002932583.2	Gene:	cnnm3 / 100494851	XenbaseID:	XB-GENE-981953	Length:	823	Species:	Xenopus tropicalis

Alignment Length:	809	Identity:	266/809 - (32%)
Similarity:	400/809 - (49%)	Gaps:	157/809 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RIVGIRLEDET-VETKNGIPTVLVDKEQQFRVFGSGLEENTAITFTNEKND------YGGPCLK- 113
            :::|:|||:.. |....|:.........:.|::||||           :||      .|.|..|
Frog    54 QVLGLRLEEGAGVSMSGGLIRARPGSSFRLRLYGSGL-----------RNDTWPWVSIGSPGSKT 107

  Fly   114 --PATDLFTPIEVSSNGFSALYSVKFPSFINEFFICAKTAEKTT----NHSKA-ATTTPL-EHQG 170
              |..|  :|:::                :.||.:|::.:...|    |.||. ....|| ..||
Frog   108 CSPEPD--SPLQL----------------LEEFRVCSEHSGLVTVRALNESKGRGLLYPLCTRQG 154

  Fly   171 NS-------DFL-----------------------------KIKTFEPLIP-------------- 185
            ||       |.|                             ::.:|....|
Frog   155 NSWAPFPGGDTLITVLGGDEEEEKPPWPGDEQQCTLGSLSSRLLSFRDETPSVAPPETNARQYLA 219

  Fly   186 VWLAIIIIVTCLGFSALFSGLNLGLMSMDRTELKILRNTGTEKEKKYASKIAPVRDQ-GNYLLCS 249
            .||..::||.|:.||.|..||.|..::::.:||.:||:.||..|:..|:::.|:|.: |.|.|.|
Frog   220 SWLLALLIVLCILFSGLLRGLQLSTLALEPSELGLLRDWGTPSERHGATRLDPLRTRWGGYTLIS 284

  Fly   250 ILLGNVLVNSTFTILLDGLTSGLFAVIFSTLAIVLF-GEITPQAVCSRHGLAIGAKTILVTKTVM 313
            :|....|.||...:||......:.|.|||...::|. ||..|.||.||.||.:..|.:.:|...|
Frog   285 MLALCCLTNSAVAVLLYHAIGSIPAAIFSAAGLLLLAGEALPAAVSSRWGLILAPKCLWLTHFFM 349

  Fly   314 AITAPLSYPVSRILDKLLGEEIGNVYNRERLKELVRVTNDVNDLDKNEVNIISGALELRKKTVAD 378
            .:...||:|:|.:|:...|::......|.|:.|:.|..:..::|.::|.:  .||  ||.:||.|
Frog   350 FLAGLLSFPLSWLLEAAFGQDPSCCRQRVRILEMARCGDPYSELVRDEFS--KGA--LRNRTVED 410

  Fly   379 VMTHINDAFMLSLDALLDFETVSEIMNSGYSRIPVYDGDRKNIVTLLYIKDLAFVDTDDNTPLKT 443
            ::|.:.:.|||..||||||.|:|.||.|||:|||||:.:|.|||.:||.|||||||..|.|||..
Frog   411 ILTPVVECFMLPSDALLDFNTMSSIMESGYTRIPVYENERSNIVDILYAKDLAFVDPQDCTPLNY 475

  Fly   444 LCEFYQNPVHFVFEDYTLDIMFNQFKEGTIGHIAFVHRVNNEGDGDPFYETVGLVTLEDVIEELI 508
            :..||.:||||||.|..||.:..:||:|. .|:|.|.:|||||:||||||.:|||||||||||:|
Frog   476 ITRFYSHPVHFVFSDTKLDAVLEEFKKGK-SHMAIVQKVNNEGEGDPFYEVMGLVTLEDVIEEII 539

  Fly   509 QAEIVDETDVFVDNRTKTRRNRYK---------KADFSAFAERREVQTVRISPQLTLATFQYLST 564
            ::||:||::   |.:.|.::.|..         ..:.|.|......|.|:|||||.|||.::|:.
Frog   540 KSEILDESE---DCKRKVKKKRQPVQPILIPRGGEELSFFRTAEAEQKVKISPQLLLATQRFLTQ 601

  Fly   565 AVDAFKKDVISELILRRLLN-QDVFHNIKTKGKSKDDPSLYIFTQGKAVDFFVLILEGRVEVTIG 628
            .||.|....:||..|..||. ..|...:|.....:..|..:::.:.:.||:|:|||:|:|:|.||
Frog   602 EVDLFGASRVSEKALLNLLKLPGVTQEVKFDDSDRLCPEHFLYLRSQPVDYFILILQGKVQVEIG 666

  Fly   629 KEALMFESGPFTYFGTQALVPNVVIDSPTQMG----SLQSLNMDSKIRQSFVPDYSVRAISDVIY 689
            ||.|.||:|.|||:|..||       ||..:|    .:|:...||..   :.|||:|||:||:..
Frog   667 KEGLKFENGAFTYYGVAAL-------SPCLLGHHSPGIQNSPSDSSF---YYPDYTVRALSDLQI 721

  Fly   690 ITIKRVLYLTAKKATLLEKSRKSGTFSSETFDDEVERLLHSITENEKPSC----FAQNQSTRRLS 750
            :.:.||.||.|.:.:                        ||.|..:.|..    ...|..|:.|:
Frog   722 VKVNRVQYLNAVRTS------------------------HSHTSTQSPDSMELKILPNSQTQLLN 762

  Fly   751 NRSINSSPTNMNRSPDFVYNSVDEAIQDD 779
            ||::.|.......:..:..|:.::.::::
Frog   763 NRNMESESRKEITTDTWPQNAGEKVMKEE 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	DUF21	188..361	CDD:279876	58/174 (33%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	75/121 (62%)
		CAP_ED	<604..>650	CDD:294041	23/45 (51%)
cnnm3	XP_002932583.2	TlyC	221..>549	CDD:224173	150/335 (45%)
		CBS_pair_CorC_HlyC_assoc	407..536	CDD:341366	78/129 (60%)
		CBS repeat	415..481	CDD:341366	39/65 (60%)
		CBS repeat	485..536	CDD:341366	32/51 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4567
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010