DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment uex and LOC100150651

DIOPT Version :9

Sequence 1:	NP_001104390.2	Gene:	uex / 5740320	FlyBaseID:	FBgn0262124	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_021332085.1	Gene:	LOC100150651 / 100150651	-ID:	-	Length:	799	Species:	Danio rerio

Alignment Length:	772	Identity:	333/772 - (43%)
Similarity:	465/772 - (60%)	Gaps:	79/772 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TIANSFRIVGIRLE---DETVETKNGIPTVLVDKEQQFRVFGSGLEENT--AITFTNEKNDYGGP 110
            ::.:..||:|:|||   ...:.|::||..|..:.:.|.|.:|..:..:|  .|.|..:..|....
Zfish    29 SLGSDSRILGMRLERSDKPAMTTEDGIIQVTEESDIQLRFYGLQISNDTWAQIKFMEQGEDSSSD 93

  Fly   111 CLKPATD------LFTPIEVSSNGFSALYSVKFPSF-----INEFFICAKTAEKTTNHSKAATTT 164
            ..:...|      :.|.:.|:|.|.|.:..||....     ..::.:|.:...:..:..
Zfish    94 SNRTCADFTKDISVRTSMSVNSLGTSGVLGVKIKPLRKSESQRDYGLCIRQNGRWFSLG------ 152

  Fly   165 PLEHQGNSDFLKIKTFEPLIPVWLAIIIIVTCLGFSALFSGLNLGLMSMDRTELKILRNTGTEKE 229
              ||.|....::.|  :.::|:|..:|:|...|..|.:|||||||||::|..||:|:::.||:||
Zfish   153 --EHDGRLRVVEEK--KSMLPIWFQVILICCLLVLSGMFSGLNLGLMALDPMELRIVQSCGTDKE 213

  Fly   230 KKYASKIAPVRDQGNYLLCSILLGNVLVNSTFTILLDGLT-SGLFAVIFSTLAIVLFGEITPQAV 293
            ||||.||.|:|.:|||||||:||||||||:|.|||||.|. |||.||:.||:.||:||||.|||:
Zfish   214 KKYARKIEPIRRKGNYLLCSLLLGNVLVNTTLTILLDDLIGSGLGAVVASTIGIVIFGEIVPQAL 278

  Fly   294 CSRHGLAIGAKTILVTKTVMAITAPLSYPVSRILDKLLGEEIGNVYNRERLKELVRVTNDVNDLD 358
            |||||||:||.||.|||..|.:|.|||||:|::||.:||:|||.|||||:|..:::||...|||.
Zfish   279 CSRHGLAVGANTIHVTKFFMFLTFPLSYPISKLLDCVLGQEIGTVYNREKLVGMLKVTEPYNDLV 343

  Fly   359 KNEVNIISGALELRKKTVADVMTHINDAFMLSLDALLDFETVSEIMNSGYSRIPVYDGDRKNIVT 423
            |.|:|:|.||||||.|||.||||.:|:.||::.||:|||.|:||||.|||:|||||:.:|.|||.
Zfish   344 KEEMNMIQGALELRTKTVEDVMTPLNNCFMINSDAVLDFNTMSEIMESGYTRIPVYEDERTNIVD 408

  Fly   424 LLYIKDLAFVDTDDNTPLKTLCEFYQNPVHFVFEDYTLDIMFNQFKEGTIGHIAFVHRVNNEGDG 488
            :|::|||||||.||.|.|||:.:||.:||||||.|..||.|..:||:|. .|:|.|.:|||||:|
Zfish   409 ILFVKDLAFVDPDDCTTLKTITKFYNHPVHFVFHDTKLDSMLEEFKKGK-SHLAIVQKVNNEGEG 472

  Fly   489 DPFYETVGLVTLEDVIEELIQAEIVDETDVFVDNRT--KTRRNRYKKADFSAFAERREVQTVRIS 551
            |||||.:|||||||||||:|:.||:||:|::.|||.  |...|:.|: |||||....| ..|:||
Zfish   473 DPFYEVLGLVTLEDVIEEIIKCEILDESDLYTDNRNRKKVAHNKNKR-DFSAFKHESE-SKVKIS 535

  Fly   552 PQLTLATFQYLSTAVDAFKKDVISELILRRLL-NQDVFHNIKTKGKSKDDPSLYIFTQGKAVDFF 615
            |||.||..::|:|.|..|....|||.||.|:| :.||...||.....|.....|::.:||.||:|
Zfish   536 PQLLLAAHRFLATEVSLFSPSQISEKILLRILKHPDVIQEIKFNENDKKSSHHYLYLRGKPVDYF 600

  Fly   616 VLILEGRVEVTIGKEALMFESGPFTYFGTQAL-VPNVV---------------------IDSPTQ 658
            :|||:|||||..|.|.:.||:|||:::|..|| .|.:|                     ..||:.
Zfish   601 ILILQGRVEVEAGNENMKFETGPFSFYGVMALSAPTLVSVSRPRHLSLKRCSLFSRFPEFRSPSH 665

  Fly   659 MGSL--------------QSLN-----MDSKIRQSFVPDYSVRAISDVIYITIKRVLYLTAKKAT 704
            :..|              ||::     :.|.....:.||::|||::|:.::.|.|..|.....|:
Zfish   666 ISGLNRSASLSYTDRPESQSVSGSNTQLSSSALPQYTPDFNVRALADLQFVKITRSQYQNGLMAS 730

  Fly   705 LLEKSRK---SGTFSSETFDDEVERLLHSITENEKPSCFAQNQSTRRLSNRSINSSP 758
            .|:.|.:   ||.......|:......|..:||......|.:::|..|:.:  ||.|
Zfish   731 RLDSSPQSPDSGHGRQVDMDNSTSSAPHRTSENMLTLADASDETTSLLNEQ--NSQP 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
uex	NP_001104390.2	DUF21	188..361	CDD:279876	108/173 (62%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	77/121 (64%)
		CAP_ED	<604..>650	CDD:294041	24/46 (52%)
LOC100150651	XP_021332085.1	CorC_HlyC	170..>501	CDD:332085	209/331 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590145
Domainoid	1	1.000	222	1.000	Domainoid score	I2520
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	581	1.000	Inparanoid score	I984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		otm25855
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	LDO	PTHR12064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760