DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stacl and stac3

DIOPT Version :9

Sequence 1:	NP_001260996.1	Gene:	Stacl / 5740318	FlyBaseID:	FBgn0263980	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_001003505.1	Gene:	stac3 / 445111	ZFINID:	ZDB-GENE-040801-248	Length:	334	Species:	Danio rerio

Alignment Length:	487	Identity:	102/487 - (20%)
Similarity:	168/487 - (34%)	Gaps:	176/487 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   687 DSQPPRQNQMYHAVSTVLTL------RRNGASSTASEPLRPNLDGSHHLQEYTYKKITACDVCSQ 745
            |:.|..:|.:....:||..:      ..........||:....|..|..:::..||...||||::
Zfish    17 DNPPAPENVVKEDDNTVYFVYDEEVEEEEAPPPPTPEPIVQVNDKPHKFKDHYCKKPKFCDVCAR 81

  Fly   746 ILRGHTRQGLRCRICKLNAHGDCAPNLPRCQPKQKLLRRQKSTSELENRVDIEEETGADKSVQAK 810
            ::..:.:..|||:.||.|.|..|                                   ...||.:
Zfish    82 MIVLNNKFALRCKNCKTNIHHSC-----------------------------------QSYVQFQ 111

  Fly   811 QMDGSVAGGSALPVPVLSERELGRAPPPDIPIVSVSELALQEQQQQQQQQQQQHQQQQRSLASVA 875
            :..|.:                    ||.......|.|..||.....||.
Zfish   112 RCFGKI--------------------PPGFRRAYSSPLYDQEINNPGQQN--------------- 141

  Fly   876 QAAAVRAGRGVRPPPVAMPI-LGVQLQQQELQQQRGGLPVPSQDISSSSAPHSPRRQKLNLRMKS 939
                       |..||...: :||.:..:|  :::|     |:|          ::..:.:.|:.
Zfish   142 -----------RTDPVFDTLRVGVIMANKE--RKKG-----SED----------KKNMMMMMMEE 178

  Fly   940 LSLDSPESSELHGQFRRRTQLPGTGASTSAGSGYYHGGSGGHLEHSTPPSNNSRLHSPSSPSHPG 1004
            .....|:..|             .||         .|...|..:..|
Zfish   179 EEAQQPKEDE-------------EGA---------EGKQDGDKKDKT------------------ 203

  Fly  1005 RKLLYATRGMRGGSVDLPDEMEKSQSSASTSPCLSPKTHRLLPTNLYVIIYNFKARHADELDLKA 1069
                 ||          .|:.:|.|.:.|.|             :.|:.:|.|||...|:||...
Zfish   204 -----AT----------DDKNKKQQQTFSQS-------------HYYMALYRFKAIEKDDLDFHP 240

  Fly  1070 GYKVTVIDNSDPDWWKGKVLGRVGYFPSKYCVRLNANEKPLQVTHNLQVSDSERGENLTLLRDQI 1134
            |.::||:|:|:.:||:||:..:.||.|..|.:|:.|.|:..:||.:. |.:.|.|: :||.:|||
Zfish   241 GDRITVLDDSNEEWWRGKIGEKTGYLPMTYIIRVRAGERVYKVTRSF-VGNREMGQ-ITLKKDQI 303

  Fly  1135 VIQTGDEVNGMVMIRAAEHGQGYCPIKYLQEV 1166
            |::.|:||||.:.:..... .|:.|...|.|:
Zfish   304 VVKKGEEVNGYLKVSTGRK-LGFFPADLLHEL 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stacl	NP_001260996.1	BAR	290..489	CDD:299863
		C1	727..773	CDD:237996	15/45 (33%)
		SH3	1051..1102	CDD:302595	21/50 (42%)
stac3	NP_001003505.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		3/8 (38%)
		C1	63..108	CDD:237996	15/79 (19%)
		STAC2_u1	120..>197	CDD:293269	21/141 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..215		12/91 (13%)
		SH3	221..273	CDD:302595	21/51 (41%)
		SH3	280..330	CDD:302595	18/52 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25075
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15135
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1389
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010