DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stacl and Stac

DIOPT Version :9

Sequence 1:	NP_001260996.1	Gene:	Stacl / 5740318	FlyBaseID:	FBgn0263980	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	XP_343492.4	Gene:	Stac / 363152	RGDID:	1305745	Length:	403	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	126/539 - (23%)
Similarity:	201/539 - (37%)	Gaps:	177/539 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   646 EPTSPRNERKFSAATAPSMKTKWLKAFKSLK-PAGSGSAQQADSQPPRQNQMYHAVSTVLTLRRN 709
            :|.||        |:..|:::|..|..:||. ...|..::.||:..||.|......:.:|.....
  Rat    24 QPPSP--------ASTSSLESKLQKLKRSLSFKTKSLRSKSADNFFPRTNSDVKPQADLLAKASP 80

  Fly   710 GAS------STASEPLRPNL-DGS----HHLQEYTYKKITACDVCSQILRG-HTRQGLRCRICKL 762
            |.|      |.||.|.:..| .||    |..||:.:||.|.||||:.::.| |.:.||||..||:
  Rat    81 GPSPIPIPGSPASMPTKAGLHPGSNSKVHAFQEHVFKKPTFCDVCNHMIVGTHAKHGLRCGACKM 145

  Fly   763 NAHGDCAPNL--PRCQPK-QKLLRRQKSTSELENRVDIEEETGADKSVQAKQMDGSVAGGSALPV 824
            :.|..||..|  .||..| .|..||..|:..|     |.|:.|..|.|
  Rat   146 SIHHKCADGLAPQRCMGKLPKGFRRYYSSPLL-----IHEQFGCIKEV----------------- 188

  Fly   825 PVLSERELGRAPPPDIPIVSVSELALQEQQQQQQQQQQQHQQQQRSLASVAQAAAVRAGRGVRPP 889
                           :||.                                      .|..|.|.
  Rat   189 ---------------MPIA--------------------------------------CGNKVDPV 200

  Fly   890 PVAMPILGVQLQQQELQQQRGGLPVPSQDISSSSAPHSPRRQKLNLRMKSLSLDSPESSELHGQF 954
            ..|:. .|..|.|:..:...|         |.|.:|  ||.....|      ::.||.::
  Rat   201 YEALR-FGTSLAQRTKKSSSG---------SGSDSP--PRTSTSEL------VEVPEEAD----- 242

  Fly   955 RRRTQLPGTGASTSAGSGYYHGGSGGHLEHSTPPSNNSRLHSPSSPSHPGRKLLYATRGMRGGSV 1019
                   |.|.|:                 ...|.:||....|.:                 |:.
  Rat   243 -------GPGDSS-----------------DIRPRSNSVFTYPEN-----------------GTD 266

  Fly  1020 DLPDEME--KSQSSASTSPCLSPKTHRLLPTNLYVIIYNFKARHADELDLKAGYKVTVIDNSDPD 1082
            |..|:::  ..|...|..|         |..|.||.:|.|..:..::|:::.|..:|::::|:.|
  Rat   267 DFRDQVKTINHQGPLSKDP---------LQMNTYVALYRFIPQENEDLEMRPGDMITLLEDSNED 322

  Fly  1083 WWKGKVLGRVGYFPSKYCVRLNANEKPLQVTHNLQVSDSERGENLTLLRDQIVIQTGDEVNGMVM 1147
            |||||:..|||:||:.:..|:..:||..:..... :...::|: :||..:||.:.:.:|.:|.:.
  Rat   323 WWKGKIQDRVGFFPANFVQRVEEHEKIYRCVRTF-IGCKDQGQ-ITLKENQICVTSEEERDGFIR 385

  Fly  1148 IRAAEHGQGYCPIKYLQEV 1166
            :.:.:. :|..|:..|.:|
  Rat   386 VLSGKK-RGLVPLDVLVDV 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stacl	NP_001260996.1	BAR	290..489	CDD:299863
		C1	727..773	CDD:237996	22/48 (46%)
		SH3	1051..1102	CDD:302595	19/50 (38%)
Stac	XP_343492.4	C1	109..160	CDD:237996	22/50 (44%)
		STAC2_u1	167..>262	CDD:293269	33/216 (15%)
		SH3_Stac_1	290..342	CDD:212767	19/51 (37%)
		SH3	349..399	CDD:302595	9/52 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10604
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45320
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15135
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1389
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010