DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stacl and Stac2

DIOPT Version :9

Sequence 1:	NP_001260996.1	Gene:	Stacl / 5740318	FlyBaseID:	FBgn0263980	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_666140.1	Gene:	Stac2 / 217154	MGIID:	2144518	Length:	408	Species:	Mus musculus

Alignment Length:	459	Identity:	97/459 - (21%)
Similarity:	157/459 - (34%)	Gaps:	164/459 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   718 PLRP-NLDGSHHLQEYTYKKITACDVCSQILRGHTRQGLRCRICKLNAHGDCAPNL--PRCQPKQ 779
            ||:| .|   |..||:.:|:.:.|::|.|::.|:::|||||:.||::.|..|:..:  .:|..|.
Mouse   104 PLKPVRL---HSFQEHVFKRASPCELCHQLIVGNSKQGLRCKTCKVSVHLWCSEEISHQQCPGKT 165

  Fly   780 KLLRRQKSTSELENRVDIEEETGADKSVQAKQMDGSVAGGSALPVPVLSERELGRAPPPDIPIVS 844
            ....|:..:|.|                                        |..||||
Mouse   166 STSFRRNFSSPL----------------------------------------LVHAPPP------ 184

  Fly   845 VSELALQEQQQQQQQQQQQHQQQQRSLASVAQAAAVRAGRGVRPPPVAMPILGVQLQQQELQQQR 909
                                       |......:...|...:..||             .:..|
Mouse   185 ---------------------------ACAMNKESPPTGTSGKVDPV-------------YETLR 209

  Fly   910 GGLPVPSQDISS-SSAPHSPRRQKLNLRMKSLSLDSPESSELHGQFRRRTQLPG----TGASTSA 969
            .|..:...:.|| ||...||.|        |||.....:.:..|..|...:.||    |..:.|.
Mouse   210 YGTSLALMNRSSFSSTSESPTR--------SLSERDELTEDGEGSIRSSEEGPGDSVFTAPAESE 266

  Fly   970 GSGYYHGGSGGHLEHSTPPSNNSRLHSPSSPSHPGRKLLYATRGMRGGSVDLPDEMEKSQSSAST 1034
            |||               |...|....|  |..|.||                          ..
Mouse   267 GSG---------------PEEKSPGQQP--PKLPLRK--------------------------DV 288

  Fly  1035 SPCLSPKTHRLLPTNLYVIIYNFKARHADELDLKAGYKVTVIDNSDPDWWKGKVLGRVGYFPSKY 1099
            .|..|           ||.:|.|..:..::|.|:.|.::.::|:|:.||||||:..|||:||:.:
Mouse   289 GPMYS-----------YVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANF 342

  Fly  1100 CVRLNANEKPLQVTHNLQVSDSERGENLTLLRDQIV--IQTGDEVNGMVMIRAAEHGQGYCPIKY 1162
            ..|:...|...:...... .:.|:| .::|..:||.  :....:.:|.:.:.:.:. :|..|...
Mouse   343 VQRVRPGENVWRCCQPFS-GNKEQG-YMSLKENQICVGVSRSKDSDGFIRVSSGKK-RGLVPADS 404

  Fly  1163 LQEV 1166
            |.|:
Mouse   405 LAEI 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stacl	NP_001260996.1	BAR	290..489	CDD:299863
		C1	727..773	CDD:237996	17/47 (36%)
		SH3	1051..1102	CDD:302595	20/50 (40%)
Stac2	NP_666140.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..97
		C1	111..161	CDD:237996	17/49 (35%)
		STAC2_u1	167..292	CDD:293269	41/261 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..286		24/91 (26%)
		SH3_Stac2_C	293..345	CDD:212918	21/62 (34%)
		SH3	352..403	CDD:302595	8/53 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10824
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43247
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15135
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1389
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010