Protein Alignment Nox and FRE4

DIOPT Version :9

• Sequence 1: NP_001097336.1
• Gene: Nox / 5740310
• FlyBaseID: FBgn0085428
• Length: 1340
• Species: Drosophila melanogaster
• Sequence 2: NP_014458.1
• Gene: FRE4 / 855797
• SGDID: S000005343
• Length: 719
• Species: Saccharomyces cerevisiae
• Alignment Length: 556
• Identity: 108/556 - (19%)
• Similarity: 192/556 - (34%)
• Gaps: 165/556 - (29%)

  Fly   507 LPHQFS----LAYMKNNQVFVTYLFFYITVNLCLFISRA-----IQYRASNGFVIIARACGQCLN 562
            ||.:|.    |.|:..:.:|:.|.:.|...::.....||     :.||:.
Yeast   225 LPTRFETLVILGYLILHTIFMAYKYQYDPYHIIFAAHRAEVAHFVAYRSG--------------- 274

  Fly   563 FNCAWVLVLMLRHSLTYLRGRGLSSYLPL------DHHVYLHKLTGITISVLSLIHTIMHLFNFS 621
                   :|...|....:...|.:::|.|      ...:..||..|    .:..:..|:|...|:
Yeast   275 -------ILSFAHLPLIVLFAGRNNFLQLISGLKHTSFIVFHKWLG----RMMFLDAIIHAAGFT 328

  Fly   622 IIVINDPNINAGHYTIGEWLLTDRPGLFGLIPGCANPTGVALLAILVVMFVCSQPFVRRKGSFEV 686
            ...:.....|.....: .|       .||:...|        ||.:::.|..:   ..|:..:|.
Yeast   329 NYYLYYKKWNTVRLRV-YW-------KFGIATTC--------LAGMLIFFSIA---AFRRHYYET 374

  Fly   687 FYWTHLLYVP-FWILCLFHGPNF--WKWFLLPGLVYIVERALRF--IWMRGEHGKTYISSGL-LL 745
            |...|:::.. |...|..|..||  .:|......::.|:|.:|.  |.:.|     :..:.| |:
Yeast   375 FMALHIVFAALFLYTCWEHVTNFSGIEWIYAAIAIWGVDRIVRITRIALLG-----FPKADLQLV 434

  Fly   746 PSKVVHLVIKRPHHF-NFRPGDYVFVN-IPAIANYEWHPFTISSAPEQEDYMWLHIRTVGEWTNR 808
            .|.:|.:.:|:|..| ..:||.||||: :..:..::.||||:..:...:..:.:.::.....|..
Yeast   435 GSDLVRVTVKKPKKFWKAKPGQYVFVSFLRPLCFWQSHPFTVMDSCVNDRELVIVLKAKKGVTKL 499

  Fly   809 LYRYFEREQQK-----------------------LQQSGSSQEIPQHMHAIPTPSFMLLNEARNP 850
            :..:.||:..|                       |..:|.|        .:|.|....|...:..
Yeast   500 VRNFVERKGGKASMRLAIEGPYGSKSTAHRFDNVLLLAGGS--------GLPGPISHALELGKTT 556

  Fly   851 AIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRT--- 912
            |.:|            ||. ||.|..||                   |::.:.:.||.|...
Yeast   557 AASG------------KNF-VQLVIAVR-------------------GLDMLNACKKELMALKGL 589

  Fly   913 -------FSRKEAVDPKK----GIPNGAFIADGERED-SNLKQRPLEKS-----ISLPDISVKSK 960
                   .|::|....:|    .:.||...|:..... ||.::.|.|..     :||.|.|:...
Yeast   590 NVQVHIYNSKQELASAEKISSNEVKNGETTAEKAPSSLSNSEKAPSESENTELPLSLNDTSISDL 654

  Fly   961 KRSRLKALRALGRSESESAFDEKRVRRARNNSVGLA 996
            :.:...    :||...|...:|     :.|:|..||
Yeast   655 EFATFH----VGRPNVEEILNE-----SVNHSGSLA 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008
		Ferric_reduct	560..700	CDD:280043	24/146 (16%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	19/76 (25%)
		FNR_like	<1136..>1178	CDD:297884
		NAD_binding_6	1158..1325	CDD:285298
FRE4	NP_014458.1	Ferric_reduct	276..389	CDD:396386	24/135 (18%)
		NOX_Duox_like_FAD_NADP	428..596	CDD:99783	40/207 (19%)
		NAD_binding_6	530..699	CDD:369657	41/201 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810