Protein Alignment Nox and FRE7

DIOPT Version :9

• Sequence 1: NP_001097336.1
• Gene: Nox / 5740310
• FlyBaseID: FBgn0085428
• Length: 1340
• Species: Drosophila melanogaster
• Sequence 2: NP_014489.2
• Gene: FRE7 / 854013
• SGDID: S000005512
• Length: 620
• Species: Saccharomyces cerevisiae
• Alignment Length: 612
• Identity: 124/612 - (20%)
• Similarity: 211/612 - (34%)
• Gaps: 203/612 - (33%)

  Fly   515 YMKNNQVFVTYLFFYITVNLCLFISRA-IQYRASNGF------------VIIARACGQCLNFN-- 564
            |.|....|||| |..:.:.|.|....| :.|.:|..|            |.:||...:.:.||
Yeast    39 YQKQYGKFVTY-FVAVIIFLSLIKKLAFMYYDSSEEFLPEKKNSPTTPSVFLARIMTKLVAFNRY 102

  Fly   565 -C------------------AWVLVLMLRHSLTYLRGRGLSSYLPLDHHVY-------------- 596
             |                  ...||:|.....|.|       |..:.|..|
Yeast   103 ICYRKFPTLIFSYLGIPTSVGTFLVVMATTLYTLL-------YCFVPHPFYRPCAGFGSPPLSVR 160

  Fly   597 ---------------------LHKLTGITISVLSLIH---TIMHLFNFSIIVINDPNINAGHYTI 637
                                 :..|.|::...:::.|   :|:.||...:.||  |.:....:..
Yeast   161 AGIMAISLVPFVFSLSGKINVIGWLVGLSYEKINIYHQWASILCLFFSWVHVI--PFLRQARHEG 223

  Fly   638 G------EWLLTD--RPGLFGLIPGCANPTGVALLAILVVMFVCSQPFVRRKGSFEVFYWTH-LL 693
            |      .|..:|  |             :||..:..|.::::.|.|..||. .:|:|...| :|
Yeast   224 GYERMHQRWKASDMWR-------------SGVPPILFLNLLWLSSLPIARRH-FYEIFLQLHWIL 274

  Fly   694 YVPFWILCLFHGPNFWKWFLLPGL---VYIVERALRFIW---------MRG--EHGKTYISSGLL 744
            .|.|:|...:|        :.|.|   :|:|  |...:|         ::|  ..|:::::|.:.
Yeast   275 AVGFYISLFYH--------VYPELNSHMYLV--ATIVVWFAQLFYRLAVKGYLRPGRSFMASTIA 329

  Fly   745 LPSKV----VHLVIKRPHHFNFRPGDYVFVNI---PAIANYEWHPFTISSAPEQEDYMWLHIRTV 802
            ..|.|    |.|::| .....:.||.::||..   ..|:|   |||:|..:.:....:.:.||..
Yeast   330 NVSIVGEGCVELIVK-DVEMAYSPGQHIFVRTIDKGIISN---HPFSIFPSAKYPGGIKMLIRAQ 390

  Fly   803 GEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAK 867
            ..::.|||...: :.:|:...|....|.:.:.:. |..:::.:.      :|..:..|   ||.|
Yeast   391 KGFSKRLYESND-DMKKILIDGPYGGIERDIRSF-TNVYLICSG------SGISTCLP---FLQK 444

  Fly   868 --------NLGVQAVPPVRPPRQN----RKPAPGAPIDPPATGVNRIRSI---KKTLQRTFSRKE 917
                    ||.|..:..|...|::    |        |...|..|.:|.:   .|.:.|.:...:
Yeast   445 YGPILHKTNLEVITLDWVVRHREDISWIR--------DEMCTLSNNLRQLFLDGKIVVRIYVCSD 501

  Fly   918 AVDPK--KGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSESESAF 980
            :..|.  |..|.   ..|...:.|:|.:|..:......|                   :||.|.|
Yeast   502 STVPGIIKTFPQ---TIDTASDQSDLAKREKDTEFGQDD-------------------TESNSTF 544

  Fly   981 DEKRVRRARNNSVGLAYLSPQNKSLAQ 1007
            |     ::.|...||..:.|....|.|
Yeast   545 D-----KSNNEYKGLITIIPSKPDLNQ 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008
		Ferric_reduct	560..700	CDD:280043	37/207 (18%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	20/81 (25%)
		FNR_like	<1136..>1178	CDD:297884
		NAD_binding_6	1158..1325	CDD:285298
FRE7	NP_014489.2	Ferric_reduct	164..278	CDD:396386	25/129 (19%)
		NOX_Duox_like_FAD_NADP	328..500	CDD:99783	41/194 (21%)
		NAD_binding_6	423..596	CDD:369657	37/189 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343215
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2122
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770