DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nox and FRE2

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_012702.1	Gene:	FRE2 / 853660	SGDID:	S000001703	Length:	711	Species:	Saccharomyces cerevisiae

Alignment Length:	601	Identity:	129/601 - (21%)
Similarity:	214/601 - (35%)	Gaps:	182/601 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 LFKVYD-IDGDGLIQHKELHDVIRHCIKENGMEFSEDQIEDLTSAMFEDA--------DPH--NS 456
            |:.:|: :|..| ..:|.|.... ..||:|...:| |.::::|::.|.|.        .|:  .|
Yeast    71 LYCIYETLDEKG-YSNKTLEKTF-STIKKNCASYS-DALQNMTNSEFYDVLNNGTRHMTPYVKGS 132

  Fly   457 GEITYEA-LKNQLHK------HG--------------------------GLLENLSIT------I 482
            ..:||.. :..||.|      ||                          |:|..::.|      :
Yeast   133 ANLTYPVEMDTQLRKAYYHALHGFYANLDVGNIYGGIICAYFVAIMAFAGVLHCMNYTPFKTVLL 197

  Fly   483 DRWLV---------PIAEDRQAGGAAKSG-FWNSLPHQFS----LAYMKNNQVFVTYLFFYITVN 533
            .:.||         |....:.|...:... |...||.:..    |.|:..:.||:.|.:.|...|
Yeast   198 KQKLVGYVRGYLTLPTIGSKHASDFSYFRIFTGYLPTRLEGIIILGYLVLHTVFLAYGYEYDPEN 262

  Fly   534 LCLFISRAIQ---YRASNG-------FVIIARACGQCLNFNCAWVLVLMLRHSLTYLRGRGLSSY 588
            : :|.||.:|   |.|...       |.:|....|: .||             |.|:.|...:|:
Yeast   263 I-IFKSRRVQVARYVADRSGVLAFAHFPLIVLFAGR-NNF-------------LEYISGVKYTSF 312

  Fly   589 LPLDHHVYLHKLTGITISVLSLIHTIMHLFNFSIIVINDPNINAGHYTIGE--WLLTDRPGLFGL 651
                  :..||..|..:.:.::||...:.                .||:..  | .|.:..|:..
Yeast   313 ------IMFHKWLGRMMFLDAMIHGSAYT----------------SYTVANKTW-ATSKNRLYWQ 354

  Fly   652 IPGCANPTGVALLAILVVMFVCSQPFVRRKGSFEVFYWTHL-LYVPFWILCLFHGPNF--WKWFL 713
            .       |||.|.:...|...|.. |.||..:|.|.:.|: |...|:..|..|..:.  .:|..
Yeast   355 F-------GVAALCLAGTMVFFSFA-VFRKYFYEAFLFLHIVLGAMFFYACWEHVVSLSGIEWIY 411

  Fly   714 LPGLVYIVERALRFIWMRGEHGKTYI----SSGLLLPSKVVHLVIKRP-HHFNFRPGDYVFVNI- 772
            ....::||:|.:|.|      ..:|.    :|..|:...::.|.:|:| ..:..:||.||||:.
Yeast   412 TAIAIWIVDRIIRII------KASYFGFPKASLQLIGDDLIRLTVKKPARPWRAKPGQYVFVSFL 470

  Fly   773 -PAIANYEW--HPFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQS-------GSSQ 827
             |.   |.|  ||||:..:..:...:.:.::.....|..:.:|..|...|....       |||.
Yeast   471 HPL---YFWQSHPFTVLDSVSKNGELVIILKEKKGVTRLVKKYVCRNGGKTSMRLAIEGPYGSSS 532

  Fly   828 EIPQHMH--------AIPTPSFMLLNEARNPAIAGERS-----ATPQTDFL---------AKNLG 870
            .:..:.:        .:|.|....:...:..|.||::|     |....|.|         .:||.
Yeast   533 PVNNYNNVLLLTGGTGLPGPIAHAIKLGKTSAAAGKQSVKLVIAVRGFDVLEAYKPELMCLENLN 597

  Fly   871 VQ-------AVPPVRP 879
            ||       .||.:.|
Yeast   598 VQLHIYNTMEVPSLTP 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	18/74 (24%)
		EFh	365..425	CDD:238008	6/22 (27%)
		EFh	399..462	CDD:238008	17/69 (25%)
		Ferric_reduct	560..700	CDD:280043	30/142 (21%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	20/79 (25%)
		FNR_like	<1136..>1178	CDD:297884
		NAD_binding_6	1158..1325	CDD:285298
FRE2	NP_012702.1	Ferric_reduct	283..396	CDD:396386	33/157 (21%)
		NOX_Duox_like_FAD_NADP	435..605	CDD:99783	38/172 (22%)
		NAD_binding_6	537..691	CDD:369657	16/77 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810