DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nox and AIM14

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_011355.1	Gene:	AIM14 / 852716	SGDID:	S000003128	Length:	570	Species:	Saccharomyces cerevisiae

Alignment Length:	326	Identity:	76/326 - (23%)
Similarity:	126/326 - (38%)	Gaps:	93/326 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   521 VFVTYLFFYITVNLCLFISRAIQYRASNGF--VIIARA--CGQCLNFNCAWVLVLM---LRHSLT 578
            |.:..|.:.|.:.|.....|....|:|:.|  .||.|.  ....::....:..||:   ..:|||
Yeast    27 VLIISLVYLIGLALLRAFGRRTPSRSSSAFKNKIIYRLYDIDPAIHLGILFFAVLIPFYYHYSLT 91

  Fly   579 -----YLRGRGLSSY--LPLDHHVYL------------------HKLTGITISVLSLIHTIMHLF 618
                 ||:..|..||  :||:..:.|                  ||.....|:|:.|:|.|..:.
Yeast    92 TQSTVYLKRLGRLSYALIPLNLFLTLRPNWFLRKNCTYTDFIPFHKWFSRIITVIGLLHGIFFII 156

  Fly   619 NFSIIVINDPNINAGHYTIGEWLLTDRPGLFGLIPGCANPTGVALLAILVVMFVCSQPFVRRKGS 683
            .::|    |.|::          |..:     ||....|..|..:..:::.:.:||...:||. :
Yeast   157 KWAI----DDNVS----------LKQK-----LILKTFNFAGFIISILVLFLLICSIGPMRRY-N 201

  Fly   684 FEVFYWTH-LLYVPFWILCLFHG-PNFWKWFLLPG----LVYIVER-----ALRFIWMRGEHGKT 737
            :.:||..| |:.|.|.:|...|. |.....|||..    .::|:.|     :|..:.....:.||
Yeast   202 YRLFYIVHNLVNVAFILLTPIHSRPGVKFPFLLLNCTLLFIHIINRIVFAKSLMILNKNANYSKT 266

  Fly   738 YISSGLLLPSKVVHLVIKR---PHHFNFRPGDYVFVNIPAIANYE------W----HPFTISSAP 789
                      .:||:.:.|   |.:  |.||.::     .|:.|.      |    ||:||:|..
Yeast   267 ----------NLVHVRLPRAILPDY--FEPGSHI-----RISPYRRINPLYWLLPSHPYTIASLA 314

  Fly   790 E 790
            |
Yeast   315 E 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008
		Ferric_reduct	560..700	CDD:280043	38/168 (23%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	16/60 (27%)
		FNR_like	<1136..>1178	CDD:297884
		NAD_binding_6	1158..1325	CDD:285298
AIM14	NP_011355.1	Ferric_reduct	104..219	CDD:396386	30/134 (22%)
		FAD_binding_8	253..365	CDD:285293	19/80 (24%)
		NAD_binding_6	372..557	CDD:369657
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810