DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and FRE8

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_013148.1	Gene:	FRE8 / 850736	SGDID:	S000004037	Length:	686	Species:	Saccharomyces cerevisiae

Alignment Length:	785	Identity:	153/785 - (19%)
Similarity:	259/785 - (32%)	Gaps:	276/785 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 DADPHNSGEITYEALKNQLHKHGGLLENLSITIDRWLVPIAE-----DRQAGGAAKSGFWNSLPH 509
            |.|.|      :..|:  :.|:..:...:|..|...::|:..     |:         |:....|
Yeast    20 DVDKH------FRTLR--VRKYSQICLLISFIIICVIIPLMNYLLLTDK---------FFKICHH 67

  Fly   510 QFSLAYMKNNQVFVTYLFFYITVNLCL----FISRAIQYRASNGFVIIARACGQCLNFNCAWVLV 570
            .....:.:.:.|..|:::...::.|||    |.|..:...|:...:.|.:..|:........:|.
Yeast    68 LKHHVFNRRSWVHKTHMYHKQSLQLCLICFVFTSFFVIQGANGDLLEITKRMGRISVALMPPLLF 132

  Fly   571 LMLRHSLTYLRGRGLSSYLPLDHHVY-----LHKLTGITISVLSLIHTIMHLFNFSIIVINDPNI 630
            |.||.|             ||.|.:|     |||.....:.:.|::||..:|:   .:.|||.
Yeast   133 LTLRPS-------------PLPHTLYLALLPLHKWISRIVVLESILHTWFYLY---YMYINDT-- 179

  Fly   631 NAGHYTIGEWLLTDRPGLFGLIPGCANPTGVALLAILVVMFVCSQPFVRRKGSFEVFYWTHLLYV 695
                             |:..:....|..||..|.:.:::.:.|..:.|| .|:.|||:.|  ||
Yeast   180 -----------------LYVKMRKLPNIYGVIALGLFLLIAITSVRYARR-WSYRVFYYVH--YV 224

  Fly   696 PFWILCLF-HGPNFWKWFLLPGLVYIVERALRFIWMRGE-----HGKTY-------ISSGLLLPS 747
            ..|::.:| |      :...||:.|..  .|..:.:.|:     |....       |||.|.|..
Yeast   225 STWLILVFLH------YHARPGISYYT--TLNVLILTGQIVYRLHITNVTRVTIVPISSSLSLLE 281

  Fly   748 KVVHLVIKRPHHFNFRPGDYVFVNIPAIANYE--------------WHPFTISSAPEQEDYMWLH 798
            ..:..:.|:|    ..||.::.:||     |.              .|||||:|.| .::.:.|.
Yeast   282 FPLTDLPKKP----ILPGGHLRINI-----YHRNFLRRFFSHLIPFQHPFTIASIP-SDNLVRLI 336

  Fly   799 IRTVGEW---TNRLYRY---FEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGERS 857
            ||. |.:   ||..|..   ||.|...:.:              ||..|.:..::
Yeast   337 IRN-GHFPLRTNEKYYITGAFEPELSFISK--------------PTVPFNITTKS---------- 376

  Fly   858 ATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTFSRKEAVDPK 922
                    :||          |.|.|......:|::         ..||  .||.|.
Yeast   377 --------SKN----------PFRNNSSALINSPLN---------FLIK--AQRVFM-------- 404

  Fly   923 KGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSR-LKALRALGRSESESAFDEKRVR 986
              ...|:.|:.|         .||.:.::...::|:....|| .|.|..|              .
Yeast   405 --CVGGSGISFG---------LPLLRILNFNGVNVRLLWVSRDYKDLEVL--------------N 444

  Fly   987 RARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGASPASRAEQGQ 1051
            ..:||..|:.......:...|..               .::..::...|.:.|. ...|.:..|:
Yeast   445 HFKNNFEGMEIYISGTEGNEQDI---------------EIDYIDYHDCAADIND-EVRSISSSGR 493

  Fly  1052 LSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGSPSRKSILRRP-----------------TFL 1099
            :|...|:         |:.::|..:|.|....|...|:||.||..                 .|.
Yeast   494 VSELGDN---------SMLSDGNPQPTEPNENTALLSKKSTLRNHHPPKTSDIPDINADDEIDFT 549

  Fly  1100 RSLSASINNRTGGGGGGSTGSSTTNSG---------------------GKVTLDAGVMEIFIDGP 1143
            .:.|.|.:.:....|..:|.||...|.                     .|:.:.||| ::|
Yeast   550 YAFSRSKSRKNTAQGTLTTHSSFNGSSVFRQPKIIEPPAQDPCLEAAPKKIRIPAGV-KVF---- 609

  Fly  1144 YGAPS 1148
            :|.|:
Yeast   610 FGRPT 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	4/15 (27%)
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008	3/11 (27%)
		Ferric_reduct	560..700	CDD:280043	35/144 (24%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	25/94 (27%)
		FNR_like	<1136..>1178	CDD:297884	3/13 (23%)
		NAD_binding_6	1158..1325	CDD:285298
FRE8	NP_013148.1	Ferric_reduct	122..232	CDD:396386	35/147 (24%)
FRE8	NP_013148.1	NOX_Duox_like_FAD_NADP	265..459	CDD:99783	57/290 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900