DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and RBOH F

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_564821.1	Gene:	RBOH F / 842710	AraportID:	AT1G64060	Length:	944	Species:	Arabidopsis thaliana

Alignment Length:	1199	Identity:	246/1199 - (20%)
Similarity:	419/1199 - (34%)	Gaps:	453/1199 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 RLTDDRQMDFAEQIESVAYVICGENKRVSFKNFRDIWHTRGILDKLYRLIELDGSNLVST----N 307
            |.:.:|...|::::::.|   ..:.|::|.:..|..| :|..           ..||.:|    |
plant    94 RTSSNRFRQFSQELKAEA---VAKAKQLSQELKRFSW-SRSF-----------SGNLTTTSTAAN 143

  Fly   308 QVMEFISHLTNS--------RPRTGFD--KSSLARLEQLFRTTVGNEQE---------------- 346
            |.......|.||        :.|...|  :||..|..:..| .:.|:|:
plant   144 QSGGAGGGLVNSALEARALRKQRAQLDRTRSSAQRALRGLR-FISNKQKNVDGWNDVQSNFEKFE 207

  Fly   347 ----IRREEFQKIVTSKNPFFTERVFQIFD------KDNSGSISLQEFIDAIHQFSGQSADDKIR 401
                |.|.:|.:.:..|:.  .|...::||      :.....|:..|..:...|.:.:|.|.:::
plant   208 KNGYIYRSDFAQCIGMKDS--KEFALELFDALSRRRRLKVEKINHDELYEYWSQINDESFDSRLQ 270

  Fly   402 FLFKVYDIDGDGLIQHKELHDVIRHCIKENGMEFSEDQIEDLTSAMFEDADPHNSGEITYEALKN 466
            ..|.:.|.:.||.|..:|:.::|......|.:...::|.|:..:.:.|:.||...|.|....|:.
plant   271 IFFDIVDKNEDGRITEEEVKEIIMLSASANKLSRLKEQAEEYAALIMEELDPERLGYIELWQLET 335

  Fly   467 QLHKHGGLLENLSITIDRWLVPIAEDRQAGGAAKSGFWNSLPHQFSLAY---MKNNQVFVTYLFF 528
            .|.:....| |.|..:......::::.| |...||..     |:.|..:   |:.|...:..|..
plant   336 LLLQKDTYL-NYSQALSYTSQALSQNLQ-GLRGKSRI-----HRMSSDFVYIMQENWKRIWVLSL 393

  Fly   529 YITVNLCLFISRAIQYRASNGF------VIIARACGQCLNFNCAWVLVLMLRHSLTYLRGRGLSS 587
            :|.:.:.||:.:..||:..:.|      ::.|:...:.|.||.|.:|..:.|:::|:||...||.
plant   394 WIMIMIGLFLWKFFQYKQKDAFHVMGYCLLTAKGAAETLKFNMALILFPVCRNTITWLRSTRLSY 458

  Fly   588 YLPLDHHVYLHKLTGITISVLSLIHTIMHL-FNFSIIVINDPNINAGHYTIGEWLL----TDRPG 647
            ::|.|.::..||.....|.|..::|...|| .:|..||      .|..|....:|.    |.:|.
plant   459 FVPFDDNINFHKTIAGAIVVAVILHIGDHLACDFPRIV------RATEYDYNRYLFHYFQTKQPT 517

  Fly   648 LFGLIPGCANPTGVALLAILVVMFVCS------------QPFVRRKGSFEVFYWTHLLYVPFWIL 700
            .|.|:.|....||:.::.::::.|..:            :||.|..| |..|:::|.|:|..:||
plant   518 YFDLVKGPEGITGILMVILMIISFTLATRWFRRNLVKLPKPFDRLTG-FNAFWYSHHLFVIVYIL 581

  Fly   701 CLFHG-------PNF----WKWFLLPGLVYIVERALRFIWMRGEHGKTYISSG---------LLL 745
            .:.||       |.:    |.:..:|.|:|..||.||           |..||         .:.
plant   582 LILHGIFLYFAKPWYVRTTWMYLAVPVLLYGGERTLR-----------YFRSGSYSVRLLKVAIY 635

  Fly   746 PSKVVHLVIKRPHHFNFRPGDYVFVNIPAIANYEWHPFTISSAPEQEDYMWLHIRTVGEWTNRLY 810
            |..|:.|.:.:|..|.::.|.|:||..||::.:|||||:|:|||| :||:.:|||.:|:||..|.
plant   636 PGNVLTLQMSKPTQFRYKSGQYMFVQCPAVSPFEWHPFSITSAPE-DDYISIHIRQLGDWTQELK 699

  Fly   811 RYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAKNLGVQAVP 875
            |.|                               :|...|.:.|
plant   700 RVF-------------------------------SEVCEPPVGG--------------------- 712

  Fly   876 PVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTFSRKEAVDPKKGIPNGAFIADGEREDSN 940
                                                          |.|:
plant   713 ----------------------------------------------KSGL--------------- 716

  Fly   941 LKQRPLEKSISLPDISVKSKKRSRLKALRALGRSESESAFDEKRVRRARNNSVGLAYLSPQNKSL 1005
                                       |||
plant   717 ---------------------------LRA----------------------------------- 719

  Fly  1006 AQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGASPASRAEQGQLSSRMDSADKLQLARLSLS 1070

plant   720 ----------------------------------------------------------------- 719

  Fly  1071 AEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSASINNRTGGGGGGSTGSSTTNSGGKVTLDAGV 1135
                     |:|     ::||:
plant   720 ---------DET-----TKKSL------------------------------------------- 727

  Fly  1136 MEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFASILQSIMHRYWK-ARHSCPRCQFEWASEIP 1199
            .::.||||||||:.........:|:|.|||.|||.|||:.:::...| ..|:.....|..:||..
plant   728 PKLLIDGPYGAPAQDYRKYDVLLLVGLGIGATPFISILKDLLNNIVKMEEHADSISDFSRSSEYS 792

  Fly  1200 ----------KSVMNLRKVDFFWINRDQRSFEWFVNLLSQL-EIEQAELGGAMERFLDMHMYITS 1253
                      |.::......|:|:.|:|.||:||..::::: |::|..:       ::||.|:||
plant   793 TGSNGDTPRRKRILKTTNAYFYWVTREQGSFDWFKGVMNEVAELDQRGV-------IEMHNYLTS 850

  Fly  1254 ALQRTDMKAVGLQLALDLLHEKGKRDLITGLKTRTNAGRPNWDKVFKQLQAQQ-KGKVTVFYCGP 1317
            ..:..|.::..:.:...|.|.|...|:::|.:.||:..||||.||..:|.::. ..::.|||||.
plant   851 VYEEGDARSALITMVQALNHAKNGVDIVSGTRVRTHFARPNWKKVLTKLSSKHCNARIGVFYCGV 915

  Fly  1318 PQLAKTLRYKCDQYG------FAFRKECF 1340
            |.|.|.|...|:.:.      |.|.||.|
plant   916 PVLGKELSKLCNTFNQKGSTKFEFHKEHF 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	39/187 (21%)
		EFh	365..425	CDD:238008	14/65 (22%)
		EFh	399..462	CDD:238008	15/62 (24%)
		Ferric_reduct	560..700	CDD:280043	43/156 (28%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	32/74 (43%)
		FNR_like	<1136..>1178	CDD:297884	19/41 (46%)
		NAD_binding_6	1158..1325	CDD:285298	55/179 (31%)
RBOH F	NP_564821.1	NADPH_Ox	169..267	CDD:400631	18/100 (18%)
		EFh	<247..294	CDD:415501	11/46 (24%)
		EF-hand_7	266..337	CDD:404394	17/70 (24%)
		Ferric_reduct	435..582	CDD:396386	42/153 (27%)
		FAD_binding_8	624..740	CDD:285293	51/413 (12%)
		NAD_binding_6	746..927	CDD:369657	56/187 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	106	1.000	Domainoid score	I2182
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I807
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.870