DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and RBOHB

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_973799.1	Gene:	RBOHB / 837430	AraportID:	AT1G09090	Length:	843	Species:	Arabidopsis thaliana

Alignment Length:	1236	Identity:	236/1236 - (19%)
Similarity:	412/1236 - (33%)	Gaps:	470/1236 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 MELEARREKQRWLLISECSALFDEGEGKHTREAFRKLFLDEEFQQKLFQLFDLERNGYLLQDRWI 241
            ||..:..|..:   ||.|.|...:..             ||::.:...::.|...|....:....
plant     6 MESSSEGETNK---ISRCKATGSDNP-------------DEDYVEITLEVRDETINTMKAKATLR 54

  Fly   242 EHLKGRL-TDDRQMDFAEQIESVAYVICGENKRVS-FKNFRDIWHTRGILDKLYRLIELDGSNLV 304
            ..|.||| |..:.:.||             ::|:. .|:|..::..||
plant    55 SVLSGRLKTMVKSLSFA-------------SRRLDRSKSFGAMFALRG----------------- 89

  Fly   305 STNQVMEFISHLTNSRPRTGFDKSSLARLEQL----------FRTTVG--NEQEIRREEFQKIVT 357
                 :.||:  .|.....|:|:.:: |.::|          |...:|  ...|...|.|:.:|.
plant    90 -----LRFIA--KNDAVGRGWDEVAM-RFDKLAVEGKLPKSKFGHCIGMVESSEFVNELFEALVR 146

  Fly   358 SKNPFFTERVFQIFDKDNSGSISLQEFIDAIHQFSGQSADDKIRFLFKVYDIDGDGLIQHKELHD 422
            .:.             ..|.||:..|..:...|.:|.|.||:::..|.:.|.:.||.|...|:.:
plant   147 RRG-------------TTSSSITKTELFEFWEQITGNSFDDRLQIFFDMVDKNLDGRITGDEVKE 198

  Fly   423 VIRHCIKENGMEFSEDQIEDLTSAMFEDADPHNSGEITYEALKNQLHKHGGLLENLSITIDRWLV 487
            :|......|.:...::.:::..:.:.|:.|..|.|.|       :||.    ||.|.:.     |
plant   199 IIALSASANKLSKIKENVDEYAALIMEELDRDNLGYI-------ELHN----LETLLLQ-----V 247

  Fly   488 PIAEDRQAGGAAKSGFWNSLPHQFSLAYMKNNQV-----FVTYLF-----------FYITVNLCL 536
            |...:.....|.|... |.:..|..:.....|.|     .::|.|           .:|::.:.|
plant   248 PSQSNNSPSSANKRAL-NKMLSQKLIPTKDRNPVKRFAMNISYFFLENWKRIWVLTLWISICITL 311

  Fly   537 FISRAIQYRASNGF------VIIARACGQCLNFNCAWVLVLMLRHSLTYLRGRG--LSSYLPLDH 593
            |..:.:||:....|      |.:|:...:.|.||.|.:|:.:.|:::|:||.:.  :.|.:|.|.
plant   312 FTWKFLQYKRKTVFEVMGYCVTVAKGSAETLKFNMALILLPVCRNTITWLRTKSKLIGSVVPFDD 376

  Fly   594 HVYLHKLTGITISVLSLIHTIMHLFNFSIIVINDPNI----NAGHYTIGEWLLTDRPGLFG-LIP 653
            ::..||:....|:|...:|.|.||      ..:.|.:    |.....:.::...:||..:| .:.
plant   377 NINFHKVVAFGIAVGIGLHAISHL------ACDFPRLLHAKNVEFEPMKKFFGDERPENYGWFMK 435

  Fly   654 GCANPTGVALLAILVVMFVCSQPFVRRKGS-----------FEVFYWTHLLYVPFWILCLFHG-- 705
            |....|||.::.:::|.:|.:|.:.||..:           |..|:::|.|:|..::|.:.||
plant   436 GTDGWTGVTMVVLMLVAYVLAQSWFRRNRANLPKSLKRLTGFNAFWYSHHLFVIVYVLLIVHGYF 500

  Fly   706 ---------PNFWKWFLLPGLVYIVERALRFIWMRGEHGKTYISSGLLLPSKVVHLVIKRPHHFN 761
                     ...|.:..:|.|:|..||.:|.  .|.......:....:.|..|:.|.:.:|..|.
plant   501 VYLSKEWYHKTTWMYLAVPVLLYAFERLIRA--FRPGAKAVKVLKVAVYPGNVLSLYMSKPKGFK 563

  Fly   762 FRPGDYVFVNIPAIANYEWHPFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSS 826
            :..|.|:::|...::..:||||:|:|| ..:||:.:||||:|:||::|...:.:..|
plant   564 YTSGQYIYINCSDVSPLQWHPFSITSA-SGDDYLSVHIRTLGDWTSQLKSLYSKVCQ-------- 619

  Fly   827 QEIPQHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAP 891
                     :|:.|
plant   620 ---------LPSTS--------------------------------------------------- 624

  Fly   892 IDPPATGVNRIRSIKKTLQRTFSRKEAVDPKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDIS 956
                                              .:|.||||
plant   625 ----------------------------------QSGLFIAD----------------------- 632

  Fly   957 VKSKKRSRLKALRALGRSESESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAF 1021

plant   633 ----------------------------------------------------------------- 632

  Fly  1022 KTPSMEEREHQVAAGEANGASPASRAEQGQLSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGS 1086
                         .|:||
plant   633 -------------IGQAN----------------------------------------------- 637

  Fly  1087 PSRKSILRRPTFLRSLSASINNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHI 1151
                :|.|.|..|                                        ||||||||:...
plant   638 ----NITRFPRLL----------------------------------------IDGPYGAPAQDY 658

  Fly  1152 FGAQHAVLIGTGIGVTPFASILQSIMHRYWKARHSCPRCQFEWASEIPKSVMNLRKVDFFWINRD 1216
            ......:|:|.|||.||..||::.:::.. |.::|..|    ..::..|:.:..::..|:|:.|:
plant   659 RNYDVLLLVGLGIGATPLISIIRDVLNNI-KNQNSIER----GTNQHIKNYVATKRAYFYWVTRE 718

  Fly  1217 QRSFEWFVNLLSQLEIEQAELGGAMERFLDMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLI 1281
            |.|.|||    |::..|.||...  |..:::|.|.||..:..|.::..:.:...|.|.|...|::
plant   719 QGSLEWF----SEVMNEVAEYDS--EGMIELHNYCTSVYEEGDARSALITMLQSLHHAKSGIDIV 777

  Fly  1282 TGLKTRTNAGRPNWDKVFKQLQAQQ-KGKVTVFYCGPPQLAKTLRYKCDQYG------FAFRKEC 1339
            :|.:.||:..||||..|||.:.... ..:|.|||||...:...|:.....:.      |.|.||.
plant   778 SGTRVRTHFARPNWRSVFKHVAVNHVNQRVGVFYCGNTCIIGELKRLAQDFSRKTTTKFEFHKEN 842

  Fly  1340 F 1340
            |
plant   843 F 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	33/163 (20%)
		EFh	365..425	CDD:238008	15/59 (25%)
		EFh	399..462	CDD:238008	13/62 (21%)
		Ferric_reduct	560..700	CDD:280043	39/157 (25%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	25/74 (34%)
		FNR_like	<1136..>1178	CDD:297884	17/41 (41%)
		NAD_binding_6	1158..1325	CDD:285298	51/167 (31%)
RBOHB	NP_973799.1	NADPH_Ox	78..173	CDD:285598	24/132 (18%)
		EF-hand_7	180..237	CDD:290234	13/63 (21%)
		EFh	180..237	CDD:298682	13/63 (21%)
		Ferric_reduct	345..494	CDD:280043	37/154 (24%)
		FAD_binding_8	537..655	CDD:285293	47/412 (11%)
		NAD_binding_6	661..825	CDD:285298	52/174 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	106	1.000	Domainoid score	I2182
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I807
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.870