DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and AT3G45810

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_190167.2	Gene:	AT3G45810 / 823724	AraportID:	AT3G45810	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	1375	Identity:	250/1375 - (18%)
Similarity:	432/1375 - (31%)	Gaps:	579/1375 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 GARDSAEEKTE--EVQPERADIRDSSDTSEAAVLDLDALDASADEPAANAGPIVASSPSILIGSV 137
            |..||.:...|  |:.|:    .|||.....:.::.:..::|    .|..|.:...|.::.:||:
plant     8 GTEDSTKWMLESVEIDPK----GDSSVKQPESTINSNNPESS----GAGGGILKNVSKNLAVGSI 64

  Fly   138 NRQEAIGSANGNGN-ANPNQRQSNLYMERYNLNLDKNCSSMELEARREKQRWLLISECSALFDEG 201
            .|..::.....:|| .:|:.|:|.      ||......|.::....:..:|
plant    65 IRSMSVNKWRKSGNLGSPSTRKSG------NLGPPLPVSQVKRPGPQRVER-------------- 109

  Fly   202 EGKHTREAFRKL----FLDEEFQQKLFQLFDLERNGYLLQDRWIEH------LKGRLTDDR---- 252
               .|..|.|.|    |||.....:       ||:.:    |.||:      :.|||..|:
plant   110 ---TTSSAARGLQSLRFLDRTVTGR-------ERDSW----RSIENRFNQFAVDGRLPKDKFGVC 160

  Fly   253 -----QMDFAEQIESVAYVICGENKRVSFKNFRDIWHTRGILDKLYRLIELDGSNLVSTNQVMEF 312
                 .::||.::    |...|..:::..:|
plant   161 IGMGDTLEFAAKV----YEALGRRRQIKTEN---------------------------------- 187

  Fly   313 ISHLTNSRPRTGFDKSSLARLEQLFRTTVGNEQEIRREEFQKIVTSKNPFFTERVFQIFDKDNSG 377
                       |.||..|    :||.     |..|:::
plant   188 -----------GIDKEQL----KLFW-----EDMIKKD--------------------------- 205

  Fly   378 SISLQEFIDAIHQFSGQSADDKIRFLFKVYDIDGDGLIQHKELHDVIRHCIKENGMEFSEDQIED 442
                              .|.:::..|.:.|.||||.:..:|:.:||......|.:...:.....
plant   206 ------------------LDCRLQIFFDMCDKDGDGKLTEEEVKEVIVLSASANRLVNLKKNAAS 252

  Fly   443 LTSAMFEDADPHNSG-------EITYEALKNQLHKHGGLLENLSIT-----------IDRWLVPI 489
            ..|.:.|:.||:..|       |:....:.:....|..:.::..:|           ..:::|..
plant   253 YASLIMEELDPNEQGYIEMWQLEVLLTGIVSNADSHKVVRKSQQLTRAMIPKRYRTPTSKYVVVT 317

  Fly   490 AEDRQAGGAAKSGFWNSLPHQFSLAYMKNNQVFVTYLFFYITVNLCLFISRAIQYRASNGFVI-- 552
            ||                     |.|....:::|..|  ::.||:.||:.:..::..|..:.|
plant   318 AE---------------------LMYEHWKKIWVVTL--WLAVNVVLFMWKYEEFTTSPLYNITG 359

  Fly   553 ----IARACGQCLNFNCAWVLVLMLRHSLTYLRGRGLSSYLPLDHHVYLHKLTGITISVLSLIHT 613
                .|:...:.|..|.|.:||.:||.:||:||...|:..:|.|.::..|||..:.|:|:||:||
plant   360 RCLCAAKGTAEILKLNMALILVPVLRRTLTFLRSTFLNHLIPFDDNINFHKLIAVAIAVISLLHT 424

  Fly   614 IMHLFNFSIIVINDPNINAGHYTI-----GEWLLTDRPGLFGLIPGCANPTGVALLAILVVMFVC 673
            .:|:      :.|.|.:::..|..     |..|...:|...||:....:.|||.::..:.:.|..
plant   425 ALHM------LCNYPRLSSCPYNFYSDYAGNLLGAKQPTYLGLMLTPVSVTGVLMIIFMGISFTL 483

  Fly   674 SQPFVRRK-----------GSFEVFYWTHLLYVPFWILCLFHG-----------PNFWKWFLLPG 716
            :..:.||.           ..|..|::.|.|.|..:.|.:.||           ...|.:..:|.
plant   484 AMHYFRRNIVKLPIPFNRLAGFNSFWYAHHLLVIAYALLIIHGYILIIEKPWYQKTTWMYVAIPM 548

  Fly   717 LVYIVERALRFIWMRGEHGKTYISSGLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIANYEWH 781
            ::|..||.  |..::..:.:.:|...::....|:.|.:.:|..|.::.|.|:||..|.|:.:|||
plant   549 VLYASERL--FSRVQEHNHRVHIIKAIVYSGNVLALYMTKPQGFKYKSGMYMFVKCPDISKFEWH 611

  Fly   782 PFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNE 846
            ||:|:|||..| |:.:|||.:|:||:.|...|....:
plant   612 PFSITSAPGDE-YLSVHIRALGDWTSELRNRFAETCE---------------------------- 647

  Fly   847 ARNPAIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQR 911
                                             |.|..||:|.
plant   648 ---------------------------------PHQKSKPSPN---------------------- 657

  Fly   912 TFSRKEAVDPKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSES 976

plant   658 ----------------------------------------------------------------- 657

  Fly   977 ESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGA 1041

plant   658 ----------------------------------------------------------------- 657

  Fly  1042 SPASRAEQGQLSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSASI 1106
                                 .|.|:...|.||: |..:::|...|
plant   658 ---------------------DLIRMETRARGAN-PHVEESQALFP------------------- 681

  Fly  1107 NNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFAS 1171
                                          .|||.||||||:.........:|||.|||.|||.|
plant   682 ------------------------------RIFIKGPYGAPAQSYQKFDILLLIGLGIGATPFIS 716

  Fly  1172 ILQSIMHRYWKARHSCPRCQFEWASEI------PKSVMNLRKVD--------------------- 1209
            ||:.:::   ..:...|:...::...:      ..||.....|:
plant   717 ILKDMLN---NLKPGIPKTGQKYEGSVGGESLGGSSVYGGSSVNGGGSVNGGGSVSGGGRKFPQR 778

  Fly  1210 --FFWINRDQRSFEWFVNLLSQLEIEQAELGGAMERFLDMHMYITSALQRTDMKAVGLQLALDLL 1272
              |:|:.|:|.|||||..::..:.:..      ....::||.|:||..:..|.::..:.:...|.
plant   779 AYFYWVTREQASFEWFKGVMDDIAVYD------KTNVIEMHNYLTSMYEAGDARSALIAMVQKLQ 837

  Fly  1273 HEKGKRDLITGLKTRTNAGRPNWDKVFKQL-QAQQKGKVTVFYCGPPQLAKTLRYKCDQYG---- 1332
            |.|...|:::..:.||:..||||.|||.:| ...:..::.|||||.|.|.:.|:..|.::.
plant   838 HAKNGVDIVSESRIRTHFARPNWRKVFSELSNKHETSRIGVFYCGSPTLVRPLKSLCQEFSLESS 902

  Fly  1333 --FAFRKECF 1340
              |.|.||.|
plant   903 TRFTFHKENF 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	25/158 (16%)
		EFh	365..425	CDD:238008	9/59 (15%)
		EFh	399..462	CDD:238008	16/69 (23%)
		Ferric_reduct	560..700	CDD:280043	43/155 (28%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	29/74 (39%)
		FNR_like	<1136..>1178	CDD:297884	21/41 (51%)
		NAD_binding_6	1158..1325	CDD:285298	52/196 (27%)
AT3G45810	NP_190167.2	FRQ1	110..270	CDD:227455	45/273 (16%)
		NADPH_Ox	110..207	CDD:285598	29/210 (14%)
		EFh	<187..234	CDD:298682	17/145 (12%)
		EFh	214..269	CDD:298682	15/54 (28%)
		Ferric_reduct	376..522	CDD:280043	41/151 (27%)
		FAD_binding_8	566..693	CDD:285293	51/411 (12%)
		NAD_binding_6	<776..894	CDD:285298	37/123 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	106	1.000	Domainoid score	I2182
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I807
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11972
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970