DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and NOX5

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_078781.3	Gene:	NOX5 / 79400	HGNCID:	14874	Length:	765	Species:	Homo sapiens

Alignment Length:	1046	Identity:	352/1046 - (33%)
Similarity:	488/1046 - (46%)	Gaps:	335/1046 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 DKSSLARLEQLFRTTVGNEQEIRREEFQKIVTSKNPFFTERVFQIFDKDNSGSISLQEFIDAIHQ 390
            |...|..:.|.|:|..|.:.||..:||:..:..|..||.||.|.:||.|.||:|:|||..:|:..
Human    24 DARWLRWVTQQFKTIAGEDGEISLQEFKAALHVKESFFAERFFALFDSDRSGTITLQELQEALTL 88

  Fly   391 FSGQSADDKIRFLFKVYDID----------------------------GDGLIQHKELHDVIRHC 427
            ....|..||::|||:|||||                            |.|.|...||..|::.|
Human    89 LIHGSPMDKLKFLFQVYDIDVCARQGASAGTEWGAGAGPHWASSPLGTGSGSIDPDELRTVLQSC 153

  Fly   428 IKENGMEFSEDQIEDLTSAMFEDADPHNSGEITYEALKNQLHKHGGLLENLSITIDRWL---VPI 489
            ::|:.:...:::::.||.|:||.||...:|.||:|.|:::|.:..|::|||:|:...||   .|.
Human   154 LRESAISLPDEKLDQLTLALFESADADGNGAITFEELRDELQRFPGVMENLTISAAHWLTAPAPR 218

  Fly   490 AEDRQAGGAAKSGFWNSLPHQFSLAYMKNNQVFVTYLFFYITVNLCLFISRAIQYRASNGFVIIA 554
            ...|:             |.|.:.||..|::..:..|..|..:::.||...|..:|.....|::|
Human   219 PRPRR-------------PRQLTRAYWHNHRSQLFCLATYAGLHVLLFGLAASAHRDLGASVMVA 270

  Fly   555 RACGQCLNFNCAWVLVLMLRHSLTYLRGRGLSSYLPLDHHVYLHKLTGITISVLSLIHTIMHLFN 619
            :.|||||||:|:::.|||||..||:||...|:..||||.::..|:|.|..:..|||:||:.|..|
Human   271 KGCGQCLNFDCSFIAVLMLRRCLTWLRATWLAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTVN 335

  Fly   620 FSIIVINDPNINAGHYTIGEWLLTDRPGLFGLIPGCANPTGVALLAILVVMFVCSQPFVRRKGSF 684
            |    :......|..:...|.|||.|||: |.:.|.|:|||||||.:|::||:||...:||.|.|
Human   336 F----VLQAQAEASPFQFWELLLTTRPGI-GWVHGSASPTGVALLLLLLLMFICSSSCIRRSGHF 395

  Fly   685 EVFYWTHLLYVPFWILCLFHGPNFWKWFLLPGLVYIVERALRFIWMRGEHGKTYISSGLLLPSKV 749
            ||||||||.|:..|:|.:|||||||||.|:||:::.:|:|:.....|  .....|....||||||
Human   396 EVFYWTHLSYLLVWLLLIFHGPNFWKWLLVPGILFFLEKAIGLAVSR--MAAVCIMEVNLLPSKV 458

  Fly   750 VHLVIKRPHHFNFRPGDYVFVNIPAIANYEWHPFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFE 814
            .||:||||..|::|||||:::|||.||.||||||||||||||:|.:|||||:.|:||||||..|:
Human   459 THLLIKRPPFFHYRPGDYLYLNIPTIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLYESFK 523

  Fly   815 REQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAKNLGVQAVPPVRP 879
            ..
Human   524 AS--------------------------------------------------------------- 525

  Fly   880 PRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTFSRKEAVDPKKGIPNGAFIADGEREDSNLKQR 944
                         ||...|
Human   526 -------------DPLGRG---------------------------------------------- 531

  Fly   945 PLEKSISLPDISVKSKKRSRLKALRALGRSESESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSF 1009
                          ||:.||...:|
Human   532 --------------SKRLSRSVTMR---------------------------------------- 542

  Fly  1010 RYMRTKPTIIAFKTPSMEEREHQVAAGEANGASPASRAEQGQLSSRMDSADKLQLARLSLSAEGA 1074

Human   543 ----------------------------------------------------------------- 542

  Fly  1075 SKPLEDQTQTGSPSRKSILRRPTFLRSLSASINNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIF 1139
                  ::|..|...:.:|.:..|..                                   ::.:
Human   543 ------KSQRSSKGSEILLEKHKFCN-----------------------------------IKCY 566

  Fly  1140 IDGPYGAPSSHIFGAQHAVLIGTGIGVTPFASILQSIMHRYWKARHSCPRCQFEWASEIPKSVMN 1204
            ||||||.|:..||.::||||||.|||:|||||||||||:|:.|.:|:||.||..|...:..: |.
Human   567 IDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSIMYRHQKRKHTCPSCQHSWIEGVQDN-MK 630

  Fly  1205 LRKVDFFWINRDQRSFEWFVNLLSQLEIEQAELGGAMERFLDMHMYITSALQRTDMKAVGLQLAL 1269
            |.||||.|||||||||||||:||::||::||| .....|||::|||:||||.:.||||:|||:||
Human   631 LHKVDFIWINRDQRSFEWFVSLLTKLEMDQAE-EAQYGRFLELHMYMTSALGKNDMKAIGLQMAL 694

  Fly  1270 DLLHEKGKRDLITGLKTRTNAGRPNWDKVFKQLQAQQKGKVTVFYCGPPQLAKTLRYKCDQYGFA 1334
            |||..|.|:|.||||:|||..|||:|.|||:::.|::||||.||:||.|.|||.|:..|:::||.
Human   695 DLLANKEKKDSITGLQTRTQPGRPDWSKVFQKVAAEKKGKVQVFFCGSPALAKVLKGHCEKFGFR 759

  Fly  1335 FRKECF 1340
            |.:|.|
Human   760 FFQENF 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	57/167 (34%)
		EFh	365..425	CDD:238008	30/87 (34%)
		EFh	399..462	CDD:238008	27/90 (30%)
		Ferric_reduct	560..700	CDD:280043	67/139 (48%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	51/74 (69%)
		FNR_like	<1136..>1178	CDD:297884	28/41 (68%)
		NAD_binding_6	1158..1325	CDD:285298	104/166 (63%)
NOX5	NP_078781.3	N-terminal regulatory region, interacts with the C-terminal catalytic region in a calcium-dependent manner	1..169		45/144 (31%)
		EFh	<42..87	CDD:238008	20/44 (45%)
		EF-hand_7	62..>108	CDD:290234	22/45 (49%)
		EFh	97..192	CDD:238008	29/94 (31%)
		EF-hand_7	98..190	CDD:290234	27/91 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..141		2/18 (11%)
		Ferric_reduct	296..402	CDD:280043	50/110 (45%)
		NOX_Duox_like_FAD_NADP	448..765	CDD:99783	185/600 (31%)
		C-terminal catalytic region	449..565		63/397 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158992
Domainoid	1	1.000	220	1.000	Domainoid score	I2643
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41568
Inparanoid	1	1.050	671	1.000	Inparanoid score	I737
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58487
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	1	1.000	-	-		FOG0011972
OrthoInspector	1	1.000	-	-		oto91221
orthoMCL	1	0.900	-	-		OOG6_100081
Panther	1	1.100	-	-	LDO	PTHR11972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2122
SonicParanoid	1	1.000	-	-		X9808
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800