DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and Duox2

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_077055.2	Gene:	Duox2 / 79107	RGDID:	628761	Length:	1517	Species:	Rattus norvegicus

Alignment Length:	1535	Identity:	299/1535 - (19%)
Similarity:	495/1535 - (32%)	Gaps:	653/1535 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SVSSSRSLEIPATPSRSPKKVSFSDELPQSQTPAQQPINQQSA--PTVVSHVLQQAA----QYLE 71
            |:.|.|.:.:|          |:|..|   |....:|....||  |.|...||:..|    |.|.
  Rat   429 SIQSGRDMGLP----------SYSQAL---QALGLEPPKNWSALNPKVDPQVLEATAALYNQDLS 480

  Fly    72 RL----------HG----------------ARDSAE---EKTEE---VQPERADIRDSSDTSEAA 104
            ||          ||                .||...   |.|..   .:.|.|:||::  |....
  Rat   481 RLELFLGGLLESHGDPGPLFSNIILDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNT--TLRDV 543

  Fly   105 VLDLDALDASADEP-----------------------------------AANAG----------- 123
            ::.:..:|.||.:|                                   .:.||
  Rat   544 LVAVSNVDPSALQPNVFFWQEGAPCPQPQQLTTEGLPQCVPVTVIDYFEGSGAGYGVTLLAVCCF 608

  Fly   124 PIVASSPSILIGSV-----NRQEAIGSANGNGNAN-------------PNQRQSN------LYME 164
            |:|    |::|..|     ||:..:....|..:..             |..::|:      |..:
  Rat   609 PVV----SLIIAWVVARFRNRERKMLLKKGKESLKKQTASDGVPAMEWPGPKESSYPVTVQLLPD 669

  Fly   165 RYNLNLDKNCSSME-LEARREKQRWLLISECSALFDEGEGKHTREAFRKLFLDEEFQQKLFQLFD 228
            |....|||..:.:. ::.:..:|..|::|          ..|.|   |.|.|....:..|..:|:
  Rat   670 RSLKVLDKRLTVLRTIQLQPTQQVNLILS----------SSHGR---RTLLLKIPKEYDLVLMFN 721

  Fly   229 LE--RNGY--LLQDRWIEHLKG-RLTDDRQMDFAEQIESVAYVICGENKRVSFKNFRDIWHTRGI 288
            .|  |:.:  ||||..:....| |:.   :||..|.:           ::...|..|     .||
  Rat   722 SEEDRDAFVQLLQDLCVCSTPGLRIA---EMDEKELL-----------RKAVTKQQR-----AGI 767

  Fly   289 LDKLYR-----LIELDGSN-----LVSTNQVMEFISHLTNSRPRTGFDKSSLARLEQLFRTTVGN 343
            |:..:|     :::::.::     |.|:.||.|.::
  Rat   768 LEIFFRQLFAQVLDINQADAGTLPLDSSQQVREALT----------------------------- 803

  Fly   344 EQEIRREEFQKIVTSK-NPFFTERVFQIFDKDNSGSISLQEFIDAIHQFSGQSADDKIRFLFKVY 407
             .|:.|.||...:..| ...|.|.:|.:.|||.:|.||.:||:|.:..|...|..||.|.:|.:|
  Rat   804 -CELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYISFREFLDILVVFMKGSPQDKSRLMFTMY 867

  Fly   408 DIDGDGLIQHKELHDVIRHCIKENGMEFSEDQIEDLTSAMFEDADPHNSGEITYEALKNQLHKHG 472
            |:||:|.:..:|...::|..|:.:....|:||:.::..:||.::...:..|:|:|.....|..|.
  Rat   868 DLDGNGFLSKEEFFTMMRSFIEISNNCLSKDQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHD 932

  Fly   473 GLLENLSITI---------------------------DRWLVP--------IAEDRQAGGAAKSG 502
            ..|....:.:                           :|.:.|        :.|..|.|..|:.
  Rat   933 SDLRFTQLCVKGGAGGTGDIFKQSNACRVSFLTRTPGNRVMAPSPRLYTEALQEKMQRGFLAQK- 996

  Fly   503 FWNSLPHQFSLAYMKNNQVFVTYLFFYITVNLCLFISRAIQYRASNGF--------------VII 553
                 ..||. .:::|.:..:..:..:..:...||..||..|    ||              :|:
  Rat   997 -----LKQFK-RFVENYRRHIVCVTIFSAICAGLFADRAYYY----GFASPPTDIEETTYVGIIL 1051

  Fly   554 ARACGQCLNFNCAWVLVLMLRHSLTYLRGRGLSSYLPLDHHVYLHKLTGITISVLSLIHTIMHLF 618
            :|.....::|..:::|:.|.|:.:|:||...|:.|:|.|..|..|:...:...||:::|::.|..
  Rat  1052 SRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRWIAMAAVVLAVVHSLGHAV 1116

  Fly   619 N---FSI------------IVIND-PNINAGHYTIGEWLLTDRPGLFGLIPGCANPTGVALLAIL 667
            |   ||:            :.:|| ..:...:|.   |.....||:          |||.||.:|
  Rat  1117 NVYIFSVSPLSLMTCVFPSVFVNDGSKLPPKYYW---WFFETVPGM----------TGVLLLLVL 1168

  Fly   668 VVMFVCSQPFVRRKGSFEVFYWTHLLYVPFWILCLFHG-------PNFWKWFLLPGLVYIVERAL 725
            .:|:|.:....||. ||..|:.||.|||..:.|.:.||       |:|..:||:|.::|:.::.:
  Rat  1169 AIMYVFASHHFRRH-SFRGFWLTHHLYVVLYALIIIHGSYALIQLPSFHIYFLVPAIIYVGDKLV 1232

  Fly   726 RFIWMRGEHGKTYIS--SGLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIANYEWHPFTISSA 788
            ..     ...|..||  ...||||.|.:|..:||..|.::.|.:|.:...::...|:||||::||
  Rat  1233 SL-----SRKKVEISVVKAELLPSGVTYLQFQRPKTFEYKSGQWVRIACLSLGTNEYHPFTLTSA 1292

  Fly   789 PEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIA 853
            | .||.:.||||.||.||.||...:.
  Rat  1293 P-HEDTLSLHIRAVGPWTTRLREIYS--------------------------------------- 1317

  Fly   854 GERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTFSRKEA 918
                                 |||
  Rat  1318 ---------------------PPV----------------------------------------- 1320

  Fly   919 VDPKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSESESAFDEK 983

  Rat  1321 ----------------------------------------------------------------- 1320

  Fly   984 RVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGASPASRAE 1048

  Rat  1321 ----------------------------------------------------------------- 1320

  Fly  1049 QGQLSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSASINNRTGGG 1113

  Rat  1321 ----------------------------------------------------------------- 1320

  Fly  1114 GGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFASILQSIMH 1178
             ||::              |...::::|||:|.........:.:||:|.|||||||||||:.::.
  Rat  1321 -GGTS--------------ARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVF 1370

  Fly  1179 RYWKARHSCPRCQFEWASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQLEIEQAELGGAMER 1243
            :      |....|           |..:|:.|.|:.|.||.|||..:::.::|...:      ..
  Rat  1371 K------SSMGAQ-----------MLCKKIYFIWVTRTQRQFEWLADIIREVEENDS------RD 1412

  Fly  1244 FLDMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLITGLKTRTNAGRPNWDKVFKQLQA--QQ 1306
            .:.:|:|||...::.|::...|.:......:...|.|.|||::.|:.|||.::.....||.  .|
  Rat  1413 LVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSVTHFGRPPFELFLDSLQEVHPQ 1477

  Fly  1307 KGKVTVFYCGPPQLAKTLRYKC------DQYGFAFRKECF 1340
            ..|:.||.||||.:.|.:...|      |:..|....|.|
  Rat  1478 VHKIGVFSCGPPGMTKNVEKACQLINRQDRAHFVHHYENF 1517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	39/152 (26%)
		EFh	365..425	CDD:238008	23/59 (39%)
		EFh	399..462	CDD:238008	18/62 (29%)
		Ferric_reduct	560..700	CDD:280043	44/155 (28%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	31/74 (42%)
		FNR_like	<1136..>1178	CDD:297884	18/41 (44%)
		NAD_binding_6	1158..1325	CDD:285298	53/168 (32%)
Duox2	NP_077055.2	Peroxidase-like, mediates peroxidase activity. /evidence=ECO:0000250	30..596		35/181 (19%)
		dual_peroxidase_like	38..594	CDD:188652	35/179 (20%)
		FRQ1	<719..856	CDD:227455	41/185 (22%)
		EFh	824..885	CDD:238008	23/60 (38%)
		EFh	861..919	CDD:238008	15/57 (26%)
		Interaction with TXNDC11. /evidence=ECO:0000250	960..1214		65/278 (23%)
		Ferric_reduct	1057..1201	CDD:396386	44/157 (28%)
		NOX_Duox_like_FAD_NADP	1243..1517	CDD:99783	98/608 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810