Protein Alignment Nox and duox

DIOPT Version :9

• Sequence 1: NP_001097336.1
• Gene: Nox / 5740310
• FlyBaseID: FBgn0085428
• Length: 1340
• Species: Drosophila melanogaster
• Sequence 2: XP_017209762.1
• Gene: duox / 565097
• ZFINID: ZDB-GENE-091117-14
• Length: 1528
• Species: Danio rerio
• Alignment Length: 1217
• Identity: 253/1217 - (20%)
• Similarity: 411/1217 - (33%)
• Gaps: 451/1217 - (37%)

  Fly   220 QQKLFQLFDLERNGYLLQDRWI---EHLKGRLTDDRQ-----MDFAEQIESVAYVICGENKRVSF 276
            ::|:||.||  .||..|....:   :||...:::|.|     :...::.:.|.:...|..:....
Zfish   667 EKKVFQTFD--ENGSPLSSHSLGNQDHLNVIVSNDHQHRALLLKIPKEYDLVLFFEDGVQRSEFL 729

  Fly   277 KNFRDIWHTR----GILDKLYRLIELDGSNLVSTNQVME-FISHLTNSRPRTGFDKSSLARLEQL 336
            ...|.....|    .:::|..:.:..|........:::| |..|..:.  ....|||....|..
Zfish   730 SLLRSELEGRIQSLTVMEKSEKEMLCDAVTREQRGKIVETFFKHAFSK--VLDIDKSDAGDLSS- 791

  Fly   337 FRTTVGNEQEIRREEFQKIVTSK-NPFFTERVFQIFDKDNSGSISLQEFIDAIHQFSGQSADDKI 400
             ||....:.|:.|.||..::..| :..|.|.:|.:.|||.:|.:|.|||:|.|..|...::::|.
Zfish   792 -RTREALQCELTRAEFASVLGLKSDSLFVESMFTLADKDGNGYLSFQEFLDVIVIFMTGTSEEKS 855

  Fly   401 RFLFKVYDIDGDGLIQHKELHDVIRHCIKENGMEFSEDQIEDLTSAMFEDADPHNSGEITYEAL- 464
            :.||..:||.|||.:..:|...::|..|..:| ..|:.|.:|..:||.:.|..:|....::|..
Zfish   856 KLLFSTHDIKGDGFLSKEEFTSLLRSFIDISG-ALSKSQADDGIAAMLQTAGLYNKDRFSWEDFH 919

  Fly   465 -------------------KNQL---HKHGGLLENLSITIDRWLVPIAED--------RQAGGAA 499
                               |.:|   ||...:.:|.|.:....|....|:        ||...|.
Zfish   920 FLLRDHSAQLNIKGMEVLGKKKLGRQHKVSFIRKNSSSSSVEELTHTPEEEHGQELRQRQTKKAG 984

  Fly   500 KSGF----------WNSLPHQFSLAYMK------NNQVFVTYLFFYITVNLCLFISRAIQY---R 545
            :|..          :|..|.|..:...|      ...:..|.:.:.|:..|.|  .|.|.|   .
Zfish   985 QSQAKLYVRPQRERFNRNPVQQCVQQFKRFIENYRRHIICTVVIYAISAGLAL--ERCIYYGLQA 1047

  Fly   546 ASNGF-------VIIARACGQCLNFNCAWVLVLMLRHSLTYLRGRGLSSYLPLDHHVYLHKLTGI 603
            .|:|.       |:::|.....::|...::|:.:.|:.:|..|...|:.|:|.|..:.||:....
Zfish  1048 HSSGIPETSMVGVLVSRGSAAAISFLFPYMLLTVCRNLITMCRETFLNRYIPFDAAIDLHRQMAA 1112

  Fly   604 TISVLSLIHTIMHLFNFSIIVINDPNI----------NAGHYTIGEWLLTDRPGLFGLIPGCANP 658
            |..:||::|::.||.|..|..|:|.:|          |.|.....:|..    ..|..:||.
Zfish  1113 TALILSVVHSLGHLVNVYIFCISDLSILACLFPKVFSNNGSELPMKWTF----WFFKTVPGI--- 1170

  Fly   659 TGVALLAILVVMFVCSQPFVRRKGSFEVFYWTHLLYVPFWILCLFHG-------PNFWKWFLLPG 716
            |||.||.|...|:|.:..:.||. ||..|:.||.|||..::|.:.||       |.|..:.:.||
Zfish  1171 TGVILLLIFAFMYVFASHYFRRI-SFRGFWITHHLYVLIYVLTVVHGSYGLLQQPRFHIYLIPPG 1234

  Fly   717 LVYIVERALRFIWMRGEHGKTYISSGLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIANYEWH 781
            |:::::   :.|.:..:..:..:....||||.|..|..|||..|.:|.|.:|.:....:...|:|
Zfish  1235 LLFLLD---KLISLSRKKVEIPVLKAELLPSDVTMLEFKRPQGFVYRSGQWVRIACLTLGTDEYH 1296

  Fly   782 PFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNE 846
            |||::|||.:|. :.||||..|.||::|
Zfish  1297 PFTLTSAPHEET-LSLHIRAAGPWTSKL------------------------------------- 1323

  Fly   847 ARNPAIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQR 911
                                                                             
Zfish  1324 ----------------------------------------------------------------- 1323

  Fly   912 TFSRKEAVDPKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSES 976
                :||..|:|
Zfish  1324 ----REAYSPEK----------------------------------------------------- 1331

  Fly   977 ESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGA 1041
                                                                  ||
Zfish  1332 ------------------------------------------------------HQ--------- 1333

  Fly  1042 SPASRAEQGQLSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSASI 1106
                  |.|
Zfish  1334 ------ELG-------------------------------------------------------- 1336

  Fly  1107 NNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFAS 1171
                                       |:.::::|||:|.........:.:||:|.|||||||||
Zfish  1337 ---------------------------GLPKLYLDGPFGEGHQEWTDFEVSVLVGAGIGVTPFAS 1374

  Fly  1172 ILQSIMHRYWKARHSCPRCQFEWASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQLEIEQAE 1236
            ||:.::.:                |.: |...:.:||.|.|:.|.||.|||..:::.  |:|..:
Zfish  1375 ILKDLVFK----------------SSV-KFKFHCKKVYFLWVTRTQRQFEWLSDIIR--EVEDMD 1420

  Fly  1237 LGGAMERFLDMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLITGLKTRTNAGRPNWDKVFKQ 1301
                |:..:.:|:|||...::.|::...|.:......:...|.|.|||::.|:.|||.:......
Zfish  1421 ----MQDLVSVHIYITQLPEKFDLRTTMLYVCERHFQKVWNRSLFTGLRSVTHFGRPPFLAFLSS 1481

  Fly  1302 LQA--QQKGKVTVFYCGPPQLAKTLRYKC------DQYGFAFRKECF 1340
            ||.  .:..||.||.||||.|.|.:...|      ||..|....|.|
Zfish  1482 LQEVHPEVEKVGVFSCGPPGLTKNVEKACQQMNKRDQTHFVHHYENF 1528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	46/172 (27%)
		EFh	365..425	CDD:238008	22/59 (37%)
		EFh	399..462	CDD:238008	19/62 (31%)
		Ferric_reduct	560..700	CDD:280043	46/149 (31%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	30/74 (41%)
		FNR_like	<1136..>1178	CDD:297884	18/41 (44%)
		NAD_binding_6	1158..1325	CDD:285298	56/168 (33%)
duox	XP_017209762.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810