DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nox and nox1

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_001095857.1	Gene:	nox1 / 555604	ZFINID:	ZDB-GENE-070404-1	Length:	576	Species:	Danio rerio

Alignment Length:	894	Identity:	193/894 - (21%)
Similarity:	291/894 - (32%)	Gaps:	417/894 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   529 YITVNLCLFISRAIQYRASNGF----------VIIARACGQCLNFNCAWVLVLMLRHSLTYLRGR 583
            ::.:|:.||:...:.|.....|          :..|||....|||||..:|:.:.|:.|:.|||.
Zfish    18 WMAINIALFVHFYLFYDQGERFEYTRELLGSALAWARAPAAVLNFNCMLILLPVCRNLLSLLRGS 82

  Fly   584 ----GLSSYLPLDHHVYLHKLTGITISVLSLIHTIMHLFN----------------FSIIVINDP 628
                |.:....||.::..|||....|::::.:|||.||||                |.:.::.|.
Zfish    83 FVCCGRTVRKQLDKNLTFHKLVAYMIALMTAVHTIAHLFNAERYSNSLEGEDGDLAFELSLLQDS 147

  Fly   629 N-INAGHYTIGEWLLTDRPGLFGLIPGCANPTGVALLAILVVMFVCSQPFVRRKGSFEVFYWTHL 692
            : :|..:  :..:.......:..:....|..|||.:...|::|...|...:|| ..||||::||.
Zfish   148 SELNTTY--LNPFPSNSTTPMIFVFTSIAGLTGVVITLALILMITSSMEVIRR-SYFEVFWYTHH 209

  Fly   693 LYVPFWILCLFHG------------------------------------------PNFWKWFLLP 715
            |::.|:...:|||                                          |..|.:.:.|
Zfish   210 LFIVFFAGLVFHGAGRVVRGQVTTDPPHNNSFCEDQPDNWGKIPECPIPQFAGGSPQTWMYVIGP 274

  Fly   716 GLVYIVERALRFIWMRGEHGKTYISSGLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIANYEW 780
            .::||.||.||||  |.....|| ...::.||||:.|.:.:| .|:...|.|||:|.|||:..||
Zfish   275 MIIYICERLLRFI--RYMQPVTY-RKIVIRPSKVLELQLVKP-GFSMDVGQYVFLNCPAISQLEW 335

  Fly   781 HPFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLN 845
            ||||::|||| ||:..:|||:||:||.:|.:..|
Zfish   336 HPFTLTSAPE-EDFFSVHIRSVGDWTEKLLKMVE------------------------------- 368

  Fly   846 EARNPAIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQ 910

Zfish   369 ----------------------------------------------------------------- 368

  Fly   911 RTFSRKEAVDPKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSE 975
                         .:|.|.
Zfish   369 -------------NLPEGG---------------------------------------------- 374

  Fly   976 SESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANG 1040

Zfish   375 ----------------------------------------------------------------- 374

  Fly  1041 ASPASRAEQGQLSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSAS 1105
                    ||                                             |.::.....:
Zfish   375 --------QG---------------------------------------------PKYVLLWIFT 386

  Fly  1106 INNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFA 1170
            |.:|.|                            :|||:|..|..:|..:.::|:|.||||||||
Zfish   387 ITSRMG----------------------------VDGPFGTASEDVFHYEVSMLVGAGIGVTPFA 423

  Fly  1171 SILQSIMHRYWKARHSCPRCQFEWASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQLEIEQA 1235
            |||:||   ::|.:.|.|:             :..:::.|:|:.|:..:||||.:||..||.|..
Zfish   424 SILKSI---WYKFKDSDPK-------------LRTKRIYFYWLCRETHAFEWFADLLQVLEREME 472

  Fly  1236 ELGGAMERFLDMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLITGLKTRTNAGRPNWDKVFK 1300
            |.|  |..||...:|:|...|.....|        ::|.....|:|||||.:|:.|||||||.|:
Zfish   473 ERG--MRDFLTYKLYLTGWDQSHADHA--------MVHFDKDTDIITGLKQKTHYGRPNWDKEFE 527

  Fly  1301 QLQAQQKGKVT-VFYCGPPQLAKTLRYKCDQYG--------FAFRKECF 1340
            |::.:....|. .|.|||..|||.|..||.:|.        |.|.||.|
Zfish   528 QVRQENPSSVVGTFLCGPQALAKDLEKKCVKYSDVDPRRTKFYFNKENF 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008
		Ferric_reduct	560..700	CDD:280043	45/160 (28%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	36/74 (49%)
		FNR_like	<1136..>1178	CDD:297884	21/41 (51%)
		NAD_binding_6	1158..1325	CDD:285298	64/167 (38%)
nox1	NP_001095857.1	Ferric_reduct	66..218	CDD:280043	40/154 (26%)
nox1	NP_001095857.1	NOX_Duox_like_FAD_NADP	298..576	CDD:99783	122/606 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2122
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850