DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and DUOX1

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_059130.2	Gene:	DUOX1 / 53905	HGNCID:	3062	Length:	1551	Species:	Homo sapiens

Alignment Length:	1247	Identity:	248/1247 - (19%)
Similarity:	412/1247 - (33%)	Gaps:	512/1247 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 RKLFLDEEFQQKLFQLFDLERNGYLLQDRWIEHLKGRLTDD----RQMDFAEQIESVAYVICGEN 271
            |.|.|....:..|..||:||.....|    :|:|:|.|.:.    ::.:..|| |.:...:..|.
Human   700 RTLLLKIPKEYDLVLLFNLEEERQAL----VENLRGALKESGLSIQEWELREQ-ELMRAAVTREQ 759

  Fly   272 KRVSFKNFRDIWHTRGILDKLYRLIELDGSNLV--STNQVMEFISHLTNSRPRTGFDKSSLARLE 334
            :|...:.|     .|.:..::..:.:.|...|.  |:.:|.|.::
Human   760 RRHLLETF-----FRHLFSQVLDINQADAGTLPLDSSQKVREALT-------------------- 799

  Fly   335 QLFRTTVGNEQEIRREEFQKIVTSK-NPFFTERVFQIFDKDNSGSISLQEFIDAIHQFSGQSADD 398
                      .|:.|.||.:.:..| ...|.|.:|.:.|||.:|.:|.:||:|.:..|...|.::
Human   800 ----------CELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEE 854

  Fly   399 KIRFLFKVYDIDGDGLIQHKELHDVIRHCIKENGMEFSEDQIEDLTSAMFEDADPHNSGEITYEA 463
            |.|.:|::||.||:|||...|...::|..|:.:....|:.|:.::..:||.::...:..|:|:|.
Human   855 KSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWED 919

  Fly   464 LKNQLHKHGGLLENLSITIDRWLVP------------IAED------RQAGGAAKSGFWNSL--- 507
            ....|..|...|....:.:....||            |::|      |.:...::|.....|
Human   920 FHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQDMICPSPRVSARCSRSDIETELTPQ 984

  Fly   508 ----------PHQFSLAYMKNNQVFVTYLF----------------------------------- 527
                      |.:....:.|....|...||
Human   985 RLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSCLHQTVQQFKRFIENYRRHIGCVA 1049

  Fly   528 -FYITVNLCLFISRAIQYRAS---NGF-------VIIARACGQCLNFNCAWVLVLMLRHSLTYLR 581
             ||.... .||:.||..|..:   .|.       :|::|.....::|..:::|:.|.|:.:|:||
Human  1050 VFYAIAG-GLFLERAYYYAFAAHHTGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLR 1113

  Fly   582 GRGLSSYLPLDHHVYLHKLTGITISVLSLIHTIMHLFNFSIIVINDPNINAGHYTIGEWLLTDRP 646
            ...|:.|:|.|..|..|:|...|..||:::|::.|:.|..:..|:..::.:..:          |
Human  1114 ETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVVNVYLFSISPLSVLSCLF----------P 1168

  Fly   647 GL----------------FGLIPGCANPTGVALLAILVVMFVCSQPFVRRKGSFEVFYWTHLLYV 695
            ||                |..:||.   |||.||.||.:|:|.:....||: ||..|:.||.||:
Human  1169 GLFHDDGSELPQKYYWWFFQTVPGL---TGVVLLLILAIMYVFASHHFRRR-SFRGFWLTHHLYI 1229

  Fly   696 PFWILCLFHG-------PNFWKWFLLPGLVYIVERALRFIWMRGEHGKTYIS--SGLLLPSKVVH 751
            ..::|.:.||       |.|..:||:|.::|..::.:..     ...|..||  ...||||.|.|
Human  1230 LLYVLLIIHGSFALIQLPRFHIFFLVPAIIYGGDKLVSL-----SRKKVEISVVKAELLPSGVTH 1289

  Fly   752 LVIKRPHHFNFRPGDYVFVNIPAIANYEWHPFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFERE 816
            |..:||..|.::.|.:|.:...|:...|:||||::||| .||.:.||||..|.||.||
Human  1290 LRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAP-HEDTLSLHIRAAGPWTTRL------- 1346

  Fly   817 QQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAKNLGVQAVPPVRPPR 881
                          :.:::.||               |:|.|
Human  1347 --------------REIYSAPT---------------GDRCA----------------------- 1359

  Fly   882 QNRKPAPGAPIDPPATGVNRIRSIKKTLQRTFSRKEAVDPKKGIPNGAFIADGEREDSNLKQRPL 946

Human  1360 ----------------------------------------------------------------- 1359

  Fly   947 EKSISLPDISVKSKKRSRLKALRALGRSESESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRY 1011
                                                                           ||
Human  1360 ---------------------------------------------------------------RY 1361

  Fly  1012 MRTKPTIIAFKTPSMEEREHQVAAGEANGASPASRAEQGQLSSRMDSADKLQLARLSLSAEGASK 1076
            .:
Human  1362 PK--------------------------------------------------------------- 1363

  Fly  1077 PLEDQTQTGSPSRKSILRRPTFLRSLSASINNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFID 1141
                                                                         :::|
Human  1364 -------------------------------------------------------------LYLD 1367

  Fly  1142 GPYGAPSSHIFGAQHAVLIGTGIGVTPFASILQSIMHRYWKARHSCPRCQFEWASEIPKSVMNLR 1206
            ||:|.........:.:||:|.|||||||||||:.::.:      |...||           :..:
Human  1368 GPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFK------SSVSCQ-----------VFCK 1415

  Fly  1207 KVDFFWINRDQRSFEWFVNLLSQLEIEQAELGGAMERFLDMHMYITSALQRTDMKAVGLQLALDL 1271
            |:.|.|:.|.||.|||..:::.  |:|:.:    .:..:.:|:|||...::.|::...|.:....
Human  1416 KIYFIWVTRTQRQFEWLADIIR--EVEEND----HQDLVSVHIYITQLAEKFDLRTTMLYICERH 1474

  Fly  1272 LHEKGKRDLITGLKTRTNAGRPNWDKVFKQLQA--QQKGKVTVFYCGPPQLAKTLRYKC------ 1328
            ..:...|.|.|||::.|:.|||.::..|..||.  .|..|:.||.||||.:.|.:...|
Human  1475 FQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQ 1539

  Fly  1329 DQYGFAFRKECF 1340
            |:..|:...|.|
Human  1540 DRTHFSHHYENF 1551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	38/152 (25%)
		EFh	365..425	CDD:238008	23/59 (39%)
		EFh	399..462	CDD:238008	19/62 (31%)
		Ferric_reduct	560..700	CDD:280043	45/155 (29%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	32/74 (43%)
		FNR_like	<1136..>1178	CDD:297884	18/41 (44%)
		NAD_binding_6	1158..1325	CDD:285298	55/168 (33%)
DUOX1	NP_059130.2	Peroxidase-like, mediates peroxidase activity	26..593
		An_peroxidase	30..544	CDD:281139
		dual_peroxidase_like	32..591	CDD:188652
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..172
		EFh	820..881	CDD:238008	23/60 (38%)
		EF-hand_7	820..880	CDD:290234	23/59 (39%)
		EF-hand_7	857..921	CDD:290234	19/63 (30%)
		EFh	857..915	CDD:238008	16/57 (28%)
		Interaction with TXNDC11. /evidence=ECO:0000250	956..1248		68/306 (22%)
		Ferric_reduct	1091..1226	CDD:280043	42/148 (28%)
		NOX_Duox_like_FAD_NADP	1277..1551	CDD:99783	102/608 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810