DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and NOX4

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_001278856.1	Gene:	NOX4 / 50507	HGNCID:	7891	Length:	599	Species:	Homo sapiens

Alignment Length:	950	Identity:	179/950 - (18%)
Similarity:	281/950 - (29%)	Gaps:	485/950 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 QFSLAYMKNNQVFVTYL----------FFYITVNLCLFISRAIQYRASNGF----------VIIA 554
            ::|.::...| :|..::          |.::::|:.||....:.|.....:          :.::
Human    15 EYSFSFYPLN-IFAPFVLFPDYFCLLGFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLS 78

  Fly   555 RACGQCLNFNCAWVLVLMLRHSLTYLRGRGLSSYLP-------LDHHVYLHKLTGITISVLSLIH 612
            ||....||.||:.:|:.|.|..|.||||   |..:|       ||.....|...|:||.:.|.:|
Human    79 RASASVLNLNCSLILLPMCRTLLAYLRG---SQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVH 140

  Fly   613 TIMHL---FNFSIIVIND-PNINAGHYTIGEWLLTDRPGLFGLIPGCANPTGVALLAILVVMFVC 673
            ...||   .|||:....| ..:||..|...:    .|..||..:||.   |||.::.:|.:|...
Human   141 VAAHLVNALNFSVNYSEDFVELNAARYRDED----PRKLLFTTVPGL---TGVCMVVVLFLMITA 198

  Fly   674 SQPFVRRKGSFEVFYWTHLLYVPFWIL----------------------CL-------------- 702
            | .:..|..::::|::||.|:..|::|                      |:
Human   199 S-TYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPE 262

  Fly   703 -----FHGP----------------------------NF---WKWFLLPGLVYIVERALRFIWMR 731
                 ||.|                            ||   |.|...|..:|..||..|:|  |
Human   263 YFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYI--R 325

  Fly   732 GEHGKTYISSGLLLPSKVVHL-VIKRPHHFNFRPGDYVFVNIPAIANYEWHPFTISSAP-EQEDY 794
            .....|.||. :..||.|:.: ::|  .:|..|||.|:.::.|:::..|.||||::..| |.:..
Human   326 SNKPVTIISV-ISHPSDVMEIRMVK--ENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKAT 387

  Fly   795 MWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGERSAT 859
            ..:|::.||:||.|.
Human   388 FGVHLKIVGDWTERF-------------------------------------------------- 402

  Fly   860 PQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTFSRKEAVDPKKG 924
              .|.|.                           ||::
Human   403 --RDLLL---------------------------PPSS--------------------------- 411

  Fly   925 IPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSESESAFDEKRVRRAR 989
                        :||.:          ||.|
Human   412 ------------QDSEI----------LPFI---------------------------------- 420

  Fly   990 NNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGASPASRAEQGQLSS 1054
                             ||..|.:
Human   421 -----------------QSRNYPK----------------------------------------- 427

  Fly  1055 RMDSADKLQLARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSASINNRTGGGGGGSTG 1119

Human   428 ----------------------------------------------------------------- 427

  Fly  1120 SSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFASILQSIMHRYWKAR 1184
                              ::||||:|:|.......:.::.:..|||||||||||.:::.. ||.
Human   428 ------------------LYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDD-WKP- 472

  Fly  1185 HSCPRCQFEWASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQLEIEQAELGGAMERF----- 1244
                              ..||::.|.|:.||.:||.||.:||..|.          .:|
Human   473 ------------------YKLRRLYFIWVCRDIQSFRWFADLLCMLH----------NKFWQENR 509

  Fly  1245 ---LDMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLITGLKTRTNAGRPNWDKVFKQLQAQQ 1306
               :::.:|    |.:||    |:|   .::.||     ...|.:|...|||.|..:|.::....
Human   510 PDYVNIQLY----LSQTD----GIQ---KIIGEK-----YHALNSRLFIGRPRWKLLFDEIAKYN 558

  Fly  1307 KGK-VTVFYCGPPQLAKTLRYKCDQ---YG--FAFRKECF 1340
            :|| |.||.|||..|:|||....:|   ||  |.:.||.|
Human   559 RGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESF 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008
		Ferric_reduct	560..700	CDD:280043	48/150 (32%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	23/76 (30%)
		FNR_like	<1136..>1178	CDD:297884	17/41 (41%)
		NAD_binding_6	1158..1325	CDD:285298	53/175 (30%)
NOX4	NP_001278856.1	Ferric_reduct	90..225	CDD:280043	44/145 (30%)
NOX4	NP_001278856.1	NOX_Duox_like_FAD_NADP	332..598	CDD:99783	103/617 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820