DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and DUOX2

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_001350640.1	Gene:	DUOX2 / 50506	HGNCID:	13273	Length:	1548	Species:	Homo sapiens

Alignment Length:	1475	Identity:	283/1475 - (19%)
Similarity:	469/1475 - (31%)	Gaps:	633/1475 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HRGSVSSSRSLEIPATPSRSPKKVSFSDELPQSQTPAQQPINQQSAP------------TVVSHV 62
            |:|:            |...||::: :|.|||..........:.|:|            .:||.:
Human   563 HKGA------------PCPQPKQLT-TDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLL 614

  Fly    63 LQQAAQYLE-RLHGARDSAEEKTEEVQPERADIRDSSDTSEAAVLDLDALDASADEPAANAGPIV 126
            |.....|.. |.|   ...::|.:|           |...|||...:.|::.        .||..
Human   615 LSGVVAYFRGREH---KKLQKKLKE-----------SVKKEAAKDGVPAMEW--------PGPKE 657

  Fly   127 ASSPSIL-------IGSVNRQEAIGSANGNGNANPNQRQSNLY-MERYNLNLDKN--CSSMELEA 181
            .|||.|:       :..:||...:            .|...|. :::.||.|..|  |.::.|:.
Human   658 RSSPIIIQLLSDRCLQVLNRHLTV------------LRVVQLQPLQQVNLILSNNRGCRTLLLKI 710

  Fly   182 RREKQRWLLIS---ECSALFDE--------GEGKHT-----REAFRKLFLDEEFQQKLFQLFDLE 230
            .:|....||.|   |..|...:        ..|.|.     :|.|||....:: ::::.::|
Human   711 PKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQ-RERILEIF--- 771

  Fly   231 RNGYLLQDRWIEHLKGRLTDDRQMDFAEQIESVAYVICGENKRVSFKNFRDIWHTRGILDKLYRL 295
                      ..||..::.|..|.|                              .|.|.
Human   772 ----------FRHLFAQVLDINQAD------------------------------AGTLP----- 791

  Fly   296 IELDGSNLVSTNQVMEFISHLTNSRPRTGFDKSSLARLEQLFRTTVGNEQEIRREEFQKIVTSK- 359
                   |.|:.:|.|.::                              .|:.|.||.:.:..|
Human   792 -------LDSSQKVREALT------------------------------CELSRAEFAESLGLKP 819

  Fly   360 NPFFTERVFQIFDKDNSGSISLQEFIDAIHQFSGQSADDKIRFLFKVYDIDGDGLIQHKELHDVI 424
            ...|.|.:|.:.|||.:|.:|.:||:|.:..|...|.:||.|.:|.:||:|.:|.:...|...::
Human   820 QDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMM 884

  Fly   425 RHCIKENGMEFSEDQIEDLTSAMFEDADPHNSGEITYEALKNQLHKH----------------GG 473
            |..|:.:....|:.|:.::..:||.::...:..|:|:|.....|..|                ||
Human   885 RSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGG 949

  Fly   474 ------LLENLSITID------------RWLVPIA-EDRQAGGAA-------------------- 499
                  ..:|:|..:.            :.|.|.| |..:.||..
Human   950 NGIRDIFKQNISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEA 1014

  Fly   500 -----KSGFWNSLPHQFSLAYMKNNQVFVTYLFFYITVNLCLFISRAIQYRASNGF--------- 550
                 :.||......|:. .:::|.:..:..:..:..:.:.:|..||..|    ||
Human  1015 LQEKMQRGFLAQKLQQYK-RFVENYRRHIVCVAIFSAICVGVFADRAYYY----GFASPPSDIAQ 1074

  Fly   551 -----VIIARACGQCLNFNCAWVLVLMLRHSLTYLRGRGLSSYLPLDHHVYLHKLTGITISVLSL 610
                 :|::|.....::|..:::|:.|.|:.:|:||...|:.|:|.|..|..|:...:...||::
Human  1075 TTLVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAI 1139

  Fly   611 IHTIMHLFNFSIIVIND--------PN--INAGHYTIGE---WLLTDRPGLFGLIPGCANPTGVA 662
            :|:..|..|..|..::.        ||  :|.|.....:   |.....||:          |||.
Human  1140 LHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGM----------TGVL 1194

  Fly   663 LLAILVVMFVCSQPFVRRKGSFEVFYWTHLLYVPFWILCLFHG-------PNFWKWFLLPGLVYI 720
            ||.:|.:|:|.:....||: ||..|:.||.||:..:.|.:.||       |.|..:||:|.::|.
Human  1195 LLLVLAIMYVFASHHFRRR-SFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYG 1258

  Fly   721 VERALRFIWMRGEHGKTYIS--SGLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIANYEWHPF 783
            .::.:..     ...|..||  ...||||.|.:|..:||..|.::.|.:|.:...|:...|:|||
Human  1259 GDKLVSL-----SRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPF 1318

  Fly   784 TISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEAR 848
            |::||| .||.:.||||.||.||.||                 :||
Human  1319 TLTSAP-HEDTLSLHIRAVGPWTTRL-----------------REI------------------- 1346

  Fly   849 NPAIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTF 913

Human  1347 ----------------------------------------------------------------- 1346

  Fly   914 SRKEAVDPKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSESES 978

Human  1347 ----------------------------------------------------------------- 1346

  Fly   979 AFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGASP 1043
                              |.||                                    :.||.
Human  1347 ------------------YSSP------------------------------------KGNGC-- 1355

  Fly  1044 ASRAEQGQLSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSASINN 1108

Human  1356 ----------------------------------------------------------------- 1355

  Fly  1109 RTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFASIL 1173
                                    ||..::::|||:|.........:.:||:|.|||||||||||
Human  1356 ------------------------AGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASIL 1396

  Fly  1174 QSIMHRYWKARHSCPRCQFEWASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQLEIEQAELG 1238
            :.::.:                |.: .|.|..:|:.|.|:.|.||.|||..:::.  |:|:.:
Human  1397 KDLVFK----------------SSL-GSQMLCKKIYFIWVTRTQRQFEWLADIIQ--EVEEND-- 1440

  Fly  1239 GAMERFLDMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLITGLKTRTNAGRPNWDKVFKQLQ 1303
              .:..:.:|:|:|...::.|::...|.:......:...|.|.|||::.|:.|||.::..|..||
Human  1441 --HQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQ 1503

  Fly  1304 A--QQKGKVTVFYCGPPQLAKTLRYKC------DQYGFAFRKECF 1340
            .  .|..|:.||.||||.:.|.:...|      |:..|....|.|
Human  1504 EVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF 1548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	36/152 (24%)
		EFh	365..425	CDD:238008	21/59 (36%)
		EFh	399..462	CDD:238008	16/62 (26%)
		Ferric_reduct	560..700	CDD:280043	43/152 (28%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	32/74 (43%)
		FNR_like	<1136..>1178	CDD:297884	18/41 (44%)
		NAD_binding_6	1158..1325	CDD:285298	54/168 (32%)
DUOX2	NP_001350640.1	Peroxidase-like, mediates peroxidase activity. /evidence=ECO:0000250	30..596		10/45 (22%)
		dual_peroxidase_like	38..594	CDD:188652	9/43 (21%)
		EFh_PEF	<764..858	CDD:330173	30/178 (17%)
		EFh	824..885	CDD:238008	21/60 (35%)
		EF-hand_7	857..929	CDD:316058	18/71 (25%)
		Interaction with TXNDC11. /evidence=ECO:0000250	960..1245		65/300 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..991		4/19 (21%)
		Ferric_reduct	1088..1223	CDD:307763	40/145 (28%)
		NOX_Duox_like_FAD_NADP	1274..1548	CDD:99783	103/608 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810