DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and Duox

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster

Alignment Length:	1062	Identity:	214/1062 - (20%)
Similarity:	357/1062 - (33%)	Gaps:	411/1062 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 RP---RTGFDKSSLARLEQLFRTTVGNEQEIRREEFQKIVTSK-NPFFTERVFQIFDKDNSGSIS 380
            ||   |...|.||...:..:.||:      :.:.||...:..| |..|..::|.|.|||..|.||
  Fly   818 RPGERRRRSDASSDGEVMTVMRTS------LSKAEFAAALGMKPNDMFVRKMFNIVDKDQDGRIS 876

  Fly   381 LQEFIDAIHQFSGQSADDKIRFLFKVYDIDGDGLIQHKELHDVIRHCIK-ENGMEFSEDQIEDLT 444
            .|||::.:..||....|||:|.:|.:.|.|.:|:|...||.:::|..:: .......:||:.:|.
  Fly   877 FQEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLVEIARTTSLGDDQVTELI 941

  Fly   445 SAMFEDADPHNSGEITYEALKNQLHKHGGLLENLSITID------RWLVPIAEDRQAGGAAKSGF 503
            ..||:|....:...:||:..|..:.::.|  :.::|.:|      .:|     |.....|..:.|
  Fly   942 DGMFQDVGLEHKNHLTYQDFKLMMKEYKG--DFVAIGLDCKGAKQNFL-----DTSTNVARMTSF 999

  Fly   504 ----WNSLPHQFSLA-------YMKNNQVFVTYLFFYITVNLCLFISRAIQY---------RASN 548
                ....|..:.||       :::.|:..:.|||.:..|.:.||:.|.|.|         |...
  Fly  1000 NIEPMQDKPRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIM 1064

  Fly   549 GF-VIIARACGQCLNFNCAWVLVLMLRHSLTYLRGRGLSSYLPLDHHVYLHKLTGITISVLSLIH 612
            |. :.|.|.....|:|..:.:|:.|.|:.:|.|:...:..|:|||.|:..||:...|....|::|
  Fly  1065 GVGIAITRGSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLH 1129

  Fly   613 TIMHLFNF-SIIVINDPNIN--------AGHYTIGEWLLTDRPGL-FGLIPGCANPTGVALLAIL 667
            |:.|:.|| .:...:..|:.        |..|         :|.: |.|.......|||.|..|:
  Fly  1130 TVGHIVNFYHVSTQSHENLRCLTREVHFASDY---------KPDITFWLFQTVTGTTGVMLFIIM 1185

  Fly   668 VVMFVCSQPFVRRKGSFEVFYWTHLLYVPFWILCLFHG-------PNFWKWFLLPGLVYIVERAL 725
            .::||.:.|.:|:| ::..|:..|.||:..::|.|.||       |.||.:||.||:||.::
  Fly  1186 CIIFVFAHPTIRKK-AYNFFWNMHTLYIGLYLLSLIHGLARLTGPPRFWMFFLGPGIVYTLD--- 1246

  Fly   726 RFIWMRGEHGKTYISSGLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIANYEWHPFTISSAPE 790
            :.:.:|.::....:....||||.|:.:...||.:..:..|.:|.::..|...:|.|.||::|||
  Fly  1247 KIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAP- 1310

  Fly   791 QEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGE 855
            .|:::..||:..|.||.:|..||:
  Fly  1311 HENFLSCHIKAQGPWTWKLRNYFD----------------------------------------- 1334

  Fly   856 RSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTFSRKEAVD 920
                                          |....|.|.|
  Fly  1335 ------------------------------PCNYNPEDQP------------------------- 1344

  Fly   921 PKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSESESAFDEKRV 985

  Fly  1345 ----------------------------------------------------------------- 1344

  Fly   986 RRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGASPASRAEQG 1050

  Fly  1345 ----------------------------------------------------------------- 1344

  Fly  1051 QLSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSASINNRTGGGGG 1115

  Fly  1345 ----------------------------------------------------------------- 1344

  Fly  1116 GSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFASILQSIMHRY 1180
                                 :|.|:||:|..:...:..:.||::|.||||||:||||..::...
  Fly  1345 ---------------------KIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGT 1388

  Fly  1181 WKARHSCPRCQFEWASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQLEIEQAELGGAMERFL 1245
            ...|:|...|               :||.|.||....:.||||:::|..:|.:.      :...|
  Fly  1389 STNRYSGVAC---------------KKVYFLWICPSHKHFEWFIDVLRDVEKKD------VTNVL 1432

  Fly  1246 DMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLITGLKTRTNAGRPNWDKVFKQLQAQQK--G 1308
            ::|::||....:.|::...|.:..:......|..:.||||...:.|||:.....|.:|.:..  .
  Fly  1433 EIHIFITQFFHKFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVS 1497

  Fly  1309 KVTVFYCGPPQLAKTLRYKCDQ 1330
            |:.||.|||..|.|::...||:
  Fly  1498 KIGVFSCGPRPLTKSVMSACDE 1519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	46/150 (31%)
		EFh	365..425	CDD:238008	24/59 (41%)
		EFh	399..462	CDD:238008	17/63 (27%)
		Ferric_reduct	560..700	CDD:280043	41/149 (28%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	26/74 (35%)
		FNR_like	<1136..>1178	CDD:297884	18/41 (44%)
		NAD_binding_6	1158..1325	CDD:285298	50/168 (30%)
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008	21/60 (35%)
		EFh	860..921	CDD:238008	24/60 (40%)
		EF-hand_7	860..920	CDD:290234	24/59 (41%)
		EFh	895..966	CDD:238008	19/70 (27%)
		EF-hand_7	899..965	CDD:290234	17/65 (26%)
		Ferric_reduct	1084..1217	CDD:280043	39/142 (27%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	88/589 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446188
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11972
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840