DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and NOX1

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_008983.2	Gene:	NOX1 / 27035	HGNCID:	7889	Length:	564	Species:	Homo sapiens

Alignment Length:	918	Identity:	206/918 - (22%)
Similarity:	294/918 - (32%)	Gaps:	449/918 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 YMKNNQVFVTYLFFYITVNLCLFISRAIQYRASNGF----------VIIARACGQCLNFNCAWVL 569
            ::.|:...|.:|..::.:|:.||:...::|..::.:          :..|||...|||||...:|
Human     4 WVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLIL 68

  Fly   570 VLMLRHSLTYLRG------RGLSSYLPLDHHVYLHKLTGITISVLSLIHTIMHLFNF-------- 620
            :.:.|:.|::|||      |.|..  .|||::..|||....|.:.:.||.|.|||||
Human    69 LPVCRNLLSFLRGTCSFCSRTLRK--QLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQ 131

  Fly   621 -------SIIVINDPNINAGHYTIGEWL-------LTDRPGLFGLIPGCANPTGVALLAILVVMF 671
                   ||:.....:...|    |.||       .|.....|..|.|.   |||.:...|::|.
Human   132 ATDGSLASILSSLSHDEKKG----GSWLNPIQSRNTTVEYVTFTSIAGL---TGVIMTIALILMV 189

  Fly   672 VCSQPFVRRKGSFEVFYWTHLLYVPFWILCL-FHG------------------------------ 705
            ..:..|:|| ..||||::||.|:: |:||.| .||
Human   190 TSATEFIRR-SYFEVFWYTHHLFI-FYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDD 252

  Fly   706 --------------PNFWKWFLLPGLVYIVERALRFIWMRGEHGKTYISSGLLLPSKVVHLVIKR 756
                          |..|||.|.|.::||.||.|||  .|.:. |..|:..::.||||:.|.:.:
Human   253 RDSHCRRPKFEGHPPESWKWILAPVILYICERILRF--YRSQQ-KVVITKVVMHPSKVLELQMNK 314

  Fly   757 PHHFNFRPGDYVFVNIPAIANYEWHPFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQ 821
             ..|:...|.|:|||.|:|:..||||||::|||| ||:..:|||..|:||..|.|.||::.
Human   315 -RGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPE-EDFFSIHIRAAGDWTENLIRAFEQQY---- 373

  Fly   822 QSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKP 886

Human   374 ----------------------------------------------------------------- 373

  Fly   887 APGAPIDPPATGVNRIRSIKKTLQRTFSRKEAVDPKKGIPNGAFIADGEREDSNLKQRPLEKSIS 951

Human   374 ----------------------------------------------------------------- 373

  Fly   952 LPDISVKSKKRSRLKALRALGRSESESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKP 1016

Human   374 ----------------------------------------------------------------- 373

  Fly  1017 TIIAFKTPSMEEREHQVAAGEANGASPASRAEQGQLSSRMDSADKLQLARLSLSAEGASKPLEDQ 1081
                                     ||..|.|
Human   374 -------------------------SPIPRIE--------------------------------- 380

  Fly  1082 TQTGSPSRKSILRRPTFLRSLSASINNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGA 1146
                                                                      :|||:|.
Human   381 ----------------------------------------------------------VDGPFGT 387

  Fly  1147 PSSHIFGAQHAVLIGTGIGVTPFASILQSIMHRYWKARHSCPRCQFEWASEIPKSVMNLRKVDFF 1211
            .|..:|..:.|||:|.|||||||||||:||.:::..|.|:                :..:|:.|:
Human   388 ASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHN----------------LKTKKIYFY 436

  Fly  1212 WINRDQRSFEWFVNLLSQLEIEQAELGGAMERFLDMHMYITSALQRTDMKAVGLQLALDLLHEKG 1276
            ||.|:..:|.||.|||:.||.|..|||..  .||:..:::|.    .|...|| ..||:.  :|.
Human   437 WICRETGAFSWFNNLLTSLEQEMEELGKV--GFLNYRLFLTG----WDSNIVG-HAALNF--DKA 492

  Fly  1277 KRDLITGLKTRTNAGRPNWDKVFKQL-QAQQKGKVTVFYCGPPQLAKTLRYKCDQYG-------- 1332
             .|::||||.:|:.|||.||..|..: .:..|..|.||.|||..|||:||..|.:|.
Human   493 -TDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQ 556

  Fly  1333 FAFRKECF 1340
            |.|.||.|
Human   557 FYFNKENF 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008
		Ferric_reduct	560..700	CDD:280043	54/167 (32%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	35/74 (47%)
		FNR_like	<1136..>1178	CDD:297884	23/41 (56%)
		NAD_binding_6	1158..1325	CDD:285298	66/167 (40%)
NOX1	NP_008983.2	Ferric_reduct	66..213	CDD:307763	48/157 (31%)
		NOX_Duox_like_FAD_NADP	297..564	CDD:99783	121/609 (20%)
		Interaction with NOXO1. /evidence=ECO:0000269\|PubMed:16329988	397..536		64/164 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2122
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850