DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and Duox1

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_714961.2	Gene:	Duox1 / 266807	RGDID:	628760	Length:	1551	Species:	Rattus norvegicus

Alignment Length:	1326	Identity:	258/1326 - (19%)
Similarity:	437/1326 - (32%)	Gaps:	543/1326 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 QRQSNLYMERYNLNLDK---NCSSMELEARREKQRWLLI-------------------------S 192
            |||     :|.::..:|   ...::|.:.|:|..|.:|:                         .
  Rat   628 QRQ-----DRQSIMCEKLVGGVEALEWQGRKEPCRPVLVHLQPGQIRVVDGRLTVLRTIQLRPPQ 687

  Fly   193 ECSALFDEGEGKHTREAFRKLFLDEEFQQKLFQLFDLERNGYLLQDRWIEHLKGRLTDD----RQ 253
            :.:.:.....|:.|      |.|....:..|..||::|.....|    :|:::..|.::    ::
  Rat   688 QVNLILSSNRGRRT------LLLKIPKEYDLVLLFNMEEERQAL----VENIRAALKENGLSFQE 742

  Fly   254 MDFAEQIESVAYVICGENKRVSFKNFRDIWHTRG-ILDKLYRLIELDGSNLVSTNQVMEFISHLT 317
            .:..||          |..|.:...     ..|| :|:..:|       :|.|  ||::......
  Rat   743 WELREQ----------ELMRAAVTR-----QQRGHLLETFFR-------HLFS--QVLDINQADA 783

  Fly   318 NSRPRTGFDKSSLARLEQLFRTTVGNEQEIRREEFQKIVTSK-NPFFTERVFQIFDKDNSGSISL 381
            .:.|   .|.|:..| |.|       ..|:.|.||...:..| ...|.|.:|.:.|||.:|.:|.
  Rat   784 GTLP---LDSSTKVR-EAL-------TCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYLSF 837

  Fly   382 QEFIDAIHQFSGQSADDKIRFLFKVYDIDGDGLIQHKELHDVIRHCIKENGMEFSEDQIEDLTSA 446
            :||:|.:..|...|.::|.|.:|::||.||:|||...|...::|..|:.:....|:||:.::..:
  Rat   838 REFLDILVVFMKGSPEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKDQLAEVVES 902

  Fly   447 MFEDADPHNSGEITYEALKNQLHKHGG----------------LLENL----------------- 478
            ||.::...:..|:|:|.....|..|..                :::||
  Rat   903 MFWESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGVEVPEVIKNLCRRASYISQEKICPSPR 967

  Fly   479 ------------SITIDRWLVPIAED------RQAG------------GAAKSGFWNSLPH---- 509
                        :.:..|...|:..|      |:.|            .|.:..|..|..|
  Rat   968 MSAHCARNNTKTASSPQRLQCPVDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSRRHQTVQ 1032

  Fly   510 QFSLAYMKNNQVFVTYLFFYITVNLCLFISRAIQYRAS---NGF-------VIIARACGQCLNFN 564
            ||. .:::|.:..:..:..:.|:...||:.||..|..:   :|.       :|::|.....::|.
  Rat  1033 QFK-RFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILSRGTAASISFM 1096

  Fly   565 CAWVLVLMLRHSLTYLRGRGLSSYLPLDHHVYLHKLTGITISVLSLIHTIMHLFNFSIIVINDPN 629
            .:::|:.|.|:.:|:||...|:.|:|.|..|..|:....|..:|:::|:..|:.|..:..|:..:
  Rat  1097 FSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRFIASTAIILTVLHSAGHVVNVYLFSISPLS 1161

  Fly   630 I------NAGHYTIGE-------WLLTDRPGLFGLIPGCANPTGVALLAILVVMFVCSQPFVRRK 681
            :      :..|....|       |.....|||          |||.||..|.:|:|.:....||:
  Rat  1162 VLSCLFPDLFHDDGSEFPQKYYWWFFQTVPGL----------TGVLLLLALAIMYVFASHHFRRR 1216

  Fly   682 GSFEVFYWTHLLYVPFWILCLFHG-------PNFWKWFLLPGLVYIVERALRFIWMRGEHGKTYI 739
             ||..|:.||.||:..:||.:.||       |.|..:||:|.::|:.::.:..     ...|..|
  Rat  1217 -SFRGFWLTHHLYIFLYILLIIHGSFALIQMPRFHIFFLVPAIIYVGDKLVSL-----SRKKVEI 1275

  Fly   740 S--SGLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIANYEWHPFTISSAPEQEDYMWLHIRTV 802
            |  ...||||.|.||..:||..|.::.|.:|.:...|:...|:||||::||| .||.:.||||..
  Rat  1276 SVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAP-HEDTLSLHIRAA 1339

  Fly   803 GEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAK 867
            |.||.||
  Rat  1340 GPWTTRL---------------------------------------------------------- 1346

  Fly   868 NLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTFSRKEAVDPKKGIPNGAFIA 932
                                                            :|...|
  Rat  1347 ------------------------------------------------REIYSP----------- 1352

  Fly   933 DGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSESESAFDEKRVRRARNNSVGLAY 997

  Rat  1353 ----------------------------------------------------------------- 1352

  Fly   998 LSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGASPASRAEQGQLSSRMDSADKL 1062

  Rat  1353 ----------------------------------------------------------------- 1352

  Fly  1063 QLARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSASINNRTGGGGGGSTGSSTTNSGG 1127
                                    |:..:..|.|
  Rat  1353 ------------------------PTGDTCARYP------------------------------- 1362

  Fly  1128 KVTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFASILQSIMHRYWKARHSCPRCQF 1192
                     ::::|||:|.........:.:||:|.|||||||||||:.::.:      |...||
  Rat  1363 ---------KLYLDGPFGEGHQEWHKFEVSVLVGAGIGVTPFASILKDLVFK------SSVSCQ- 1411

  Fly  1193 EWASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQLEIEQAELGGAMERFLDMHMYITSALQR 1257
                      :..:|:.|.|:.|.||.|||..:::.::|...:      ...:.:|:|||...::
  Rat  1412 ----------VFCKKIYFIWVTRTQRQFEWLADIIREVEENDS------RDLVSVHIYITQLAEK 1460

  Fly  1258 TDMKAVGLQLALDLLHEKGKRDLITGLKTRTNAGRPNWDKVFKQLQA--QQKGKVTVFYCGPPQL 1320
            .|::...|.:......:...|.|.|||::.|:.|||.::..|..||.  .|..|:.||.||||.:
  Rat  1461 FDLRTTMLYICERHFQKVLNRSLFTGLRSVTHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGM 1525

  Fly  1321 AKTLRYKC------DQYGFAFRKECF 1340
            .|.:...|      |:..|:...|.|
  Rat  1526 TKNVEKACQLINKQDRTHFSHHYENF 1551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	45/152 (30%)
		EFh	365..425	CDD:238008	23/59 (39%)
		EFh	399..462	CDD:238008	20/62 (32%)
		Ferric_reduct	560..700	CDD:280043	42/152 (28%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	32/74 (43%)
		FNR_like	<1136..>1178	CDD:297884	18/41 (44%)
		NAD_binding_6	1158..1325	CDD:285298	54/168 (32%)
Duox1	NP_714961.2	Peroxidase-like, mediates peroxidase activity. /evidence=ECO:0000250	26..593
		dual_peroxidase_like	32..591	CDD:188652
		EFh	820..881	CDD:238008	23/60 (38%)
		EF-hand_7	853..925	CDD:404394	21/71 (30%)
		Interaction with TXNDC11. /evidence=ECO:0000250	956..1248		67/303 (22%)
		Ferric_reduct	1091..1235	CDD:396386	43/154 (28%)
		NOX_Duox_like_FAD_NADP	1277..1551	CDD:99783	99/608 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810