DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nox and frp2

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_595271.1	Gene:	frp2 / 2541227	PomBaseID:	SPBC947.05c	Length:	564	Species:	Schizosaccharomyces pombe

Alignment Length:	433	Identity:	93/433 - (21%)
Similarity:	160/433 - (36%)	Gaps:	124/433 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 NSGEITYEALKN-----QLHKHGGLLENLSITIDRWLVPIAEDRQAGGAAKSGFWNSLPHQFSLA 514
            :.||..|.||::     ..|| ..:...||..:....:|.. .::...:..|..||.......|.
pombe    53 SKGERVYLALRHWFIFLATHK-AQMTLILSPLVMLVTIPFT-GKETKNSIASYDWNLTGVAARLG 115

  Fly   515 YMKNNQVFVTYLFFYITVNLCLFISRAIQYRASNGFVIIARACGQCLNFNCAWVLVLMLRHSLTY 579
            |:.....||:|.|.......||.:
pombe   116 YLSCGLFFVSYFFSLKNNPFCLML----------------------------------------- 139

  Fly   580 LRGRGLSSYLPLDHHVYLHKLTGITISVLSLIHTIMHLFNFSIIVINDPNINAGHYTIGEWLLTD 644
                 .||:..::   |||:...:...::|::|.|:.:.           .:|..|   :.||.|
pombe   140 -----FSSHEKMN---YLHRWLSVYAVLISVLHGILFMI-----------FSAQSY---KPLLYD 182

  Fly   645 RPGLFGLIPGCANPTGVALLAILVVMFVCSQPFVRRKGSFEVFYWTHLLYVPFWILCLF----HG 705
            :..::|..          :..:|.:|.|.|.|.||||    .|.|..:|:....:|.:|    |.
pombe   183 KISIYGYF----------ITVVLFLMTVASLPSVRRK----FFEWFFVLHHTCSVLIIFLIWLHH 233

  Fly   706 PNFWKWFLLPGLVYIVERALRF---IWMRGEHGKTYISSGLLLPSKVVHLVIKRPHHFNF----R 763
            |....:.....::|..:|..|.   ||.|... :.|     ||...::::|.::|....|    .
pombe   234 PRTIVYMKACIIIYAFDRGCRLFRSIWNRSNF-RIY-----LLNEDMIYMVGRKPKRSFFALPWA 292

  Fly   764 PGDYVFVNIPAIANYEWHPFTISSAPEQEDYMWLHIRTVGEWT----NRLYRYFEREQQKLQQSG 824
            .|.:|::|||:::.::.||||::||| .:|::.|.:.....:|    ||||             .
pombe   293 AGSHVYINIPSLSYWQVHPFTLASAP-FDDFIELFVAVHSGFTERLANRLY-------------S 343

  Fly   825 SSQEIPQHMHAIPTP-----SFMLLNEARNPAIAGERSATPQT 862
            ...|.|....|..||     ::..||..::.|:..|.:|...|
pombe   344 MPHEYPNFSLAPGTPESLSNTYRELNSFKSYAVEIENTAQGHT 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	5/10 (50%)
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008	2/6 (33%)
		Ferric_reduct	560..700	CDD:280043	26/139 (19%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	24/82 (29%)
		FNR_like	<1136..>1178	CDD:297884
		NAD_binding_6	1158..1325	CDD:285298
frp2	NP_595271.1	Ferric_reduct	117..228	CDD:280043	33/187 (18%)
		NOX_Duox_like_FAD_NADP	271..488	CDD:99783	33/130 (25%)
		NAD_binding_6	414..547	CDD:285298
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810