DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nox and frp1

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_595065.1	Gene:	frp1 / 2539711	PomBaseID:	SPBC1683.09c	Length:	564	Species:	Schizosaccharomyces pombe

Alignment Length:	429	Identity:	78/429 - (18%)
Similarity:	162/429 - (37%)	Gaps:	115/429 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 YMKNNQVFVTYLFFYITVN--LCLFISRAIQYRASNGFV-------------------------I 552
            :::...:||..::.|:..:  :...|:..:.:..|..|:                         :
pombe    53 WLEKYYLFVRQIYTYLVTHKVILTLIAVPVVFAISIPFIGMQTPASSHGKQTTQVSTGNWSKNAV 117

  Fly   553 IAR----ACGQCLNF------NCAWVLVLMLRH-SLTYLRGRGLSSYLPLDHHVYLHKLTGITIS 606
            .||    |||..:..      |..:.|:|:..| .:.|:. |.||.|                ..
pombe   118 AARLGFLACGLYVTSYFFSIKNNPFALLLISSHEKMNYVH-RRLSQY----------------AI 165

  Fly   607 VLSLIHTIMHLFNFSIIVINDPNINAGHYTIGEWLLTDRPGLFGLIPGCANPTGVALLAILVVMF 671
            ::..||      .|:.|.:......|        |||.|..:.|.:          :|.::|:|.
pombe   166 MIGAIH------GFAYIGLAAQGKRA--------LLTARVTIIGYV----------ILGLMVIMI 206

  Fly   672 VCSQPFVRRKGSFEVFYWTHLLYVPFWILCLFHGPNFWKWFLLPGLVYIVERALRFIWMRGEHGK 736
            |.|.||.||:.....|...|:..:.|.|....|......:..:...||:.:|..|.:       :
pombe   207 VSSLPFFRRRFYEWFFVLHHMCSIGFLITIWLHHRRCVVYMKVCVAVYVFDRGCRML-------R 264

  Fly   737 TYISSG----LLLPSKVVHLVIKRPHHFNF----RPGDYVFVNIPAIANYEWHPFTISSAPEQED 793
            ::::..    :|:...::::...||....|    ..|:::::|||:::.::.|||||:|.| .:|
pombe   265 SFLNRSKFDVVLVEDDLIYMKGPRPKKSFFGLPWGAGNHMYINIPSLSYWQIHPFTIASVP-SDD 328

  Fly   794 YMWLHIRTVGEWTNRLYRYFERE-----------QQKLQQSGSSQEIPQHMHAIPTPSFMLLNEA 847
            ::.|.:.....:|.||.:....:           .:|::::|.........|::.....:..:.|
pombe   329 FIELFVAVRAGFTKRLAKKVSSKSLSDVSDINISDEKIEKNGDVGIEVMERHSLSQEDLVFESSA 393

  Fly   848 RNPAIAGERS----ATPQTDF-----LAKNLGVQAVPPV 877
            ...::..:..    :.|..|:     .|..:||..:.|:
pombe   394 AKVSVLMDGPYGPVSNPYKDYSYLFLFAGGVGVSYILPI 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008
		Ferric_reduct	560..700	CDD:280043	31/146 (21%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	20/89 (22%)
		FNR_like	<1136..>1178	CDD:297884
		NAD_binding_6	1158..1325	CDD:285298
frp1	NP_595065.1	Ferric_reduct	124..235	CDD:280043	34/151 (23%)
		NOX_Duox_like_FAD_NADP	279..480	CDD:99783	29/155 (19%)
		NAD_binding_6	414..547	CDD:285298	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810