DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and Nox1

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	XP_006528578.1	Gene:	Nox1 / 237038	MGIID:	2450016	Length:	591	Species:	Mus musculus

Alignment Length:	963	Identity:	208/963 - (21%)
Similarity:	299/963 - (31%)	Gaps:	494/963 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 NLSITIDRWLVPIAEDRQAGGAAKSGFWNSLPHQFSLAYMKNNQVFVTYLFFYITVNLCLFISRA 541
            ||.:|:..|||                              |:.:.|.:|..::.:|:.||:...
Mouse    24 NLHLTMGNWLV------------------------------NHWLSVLFLVSWLGLNIFLFVYAF 58

  Fly   542 IQYRASNGF----------VIIARACGQCLNFNCAWVLVLMLRHSLTYLRG------RGLSSYLP 590
            :.|..|:.:          :.:|||...|||||...:|:.:.|:.|::|||      |.|..  |
Mouse    59 LNYEKSDKYYYTREILGTALALARASALCLNFNSMMILIPVCRNLLSFLRGTCSFCNRTLRK--P 121

  Fly   591 LDHHVYLHKLTGITISVLSLIHTIMHLFNF---------------SII--------------VIN 626
            |||::..|||....|.:.::||.|.|||||               |::              .|.
Mouse   122 LDHNLTFHKLVAYMICIFTVIHIIAHLFNFERYRRSQQAMDGSLASVLSSLSHPEKEDSWLNPIQ 186

  Fly   627 DPNINAGHYTIGEWLLTDRPGLFGLIPGCANPTGVALLAILVVMFVCSQPFVRRKGSFEVFYWTH 691
            .||:..               ::......|..|||.....||:|...:..|:|| ..||:|::||
Mouse   187 SPNMTV---------------MYAAFTSIAGLTGVIATVALVLMVTSAMEFIRR-NYFELFWYTH 235

  Fly   692 LLYVPFWILCL-FHG--------------------------------------------PNFWKW 711
            .|:: .:|:|| .||                                            |..|||
Mouse   236 HLFI-VYIICLGIHGLGGIVRGQTEESLGESHPHNCSHSFHEWDDHKGSCRHPHFAGHPPESWKW 299

  Fly   712 FLLPGLVYIVERALRFIWMRGEHGKTYISSGLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIA 776
            .|.|...||.||.|||  .|.:. |..|:..::.||.|:.|.: |...|:...|.|:|||.|:|:
Mouse   300 ILAPIAFYIFERILRF--YRSQQ-KVVITKVVMHPSNVLELQM-RKRGFSMEVGQYIFVNCPSIS 360

  Fly   777 NYEWHPFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSF 841
            ..||||||::|||| |::..:|||..|:||..|.|.||:               ||
Mouse   361 FLEWHPFTLTSAPE-EEFFSVHIRAAGDWTRNLIRTFEQ---------------QH--------- 400

  Fly   842 MLLNEARNPAIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIK 906

Mouse   401 ----------------------------------------------------------------- 400

  Fly   907 KTLQRTFSRKEAVDPKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRAL 971

Mouse   401 ----------------------------------------------------------------- 400

  Fly   972 GRSESESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAG 1036

Mouse   401 ----------------------------------------------------------------- 400

  Fly  1037 EANGASPASRAEQGQLSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRS 1101
                 ||..|.|
Mouse   401 -----SPMPRIE----------------------------------------------------- 407

  Fly  1102 LSASINNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGV 1166
                                                  :|||:|..|..:|..:.|||:|.||||
Mouse   408 --------------------------------------VDGPFGTVSEDVFQYEVAVLVGAGIGV 434

  Fly  1167 TPFASILQSIMHRYWKARHSCPRCQFEWASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQLE 1231
            |||||||:||.:::.:|.:.                :..:|:.|:||.|:..:|.||.|||:.||
Mouse   435 TPFASILKSIWYKFQRADNK----------------LKTQKIYFYWICRETGAFAWFNNLLNSLE 483

  Fly  1232 IEQAELGGAMERFLDMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLITGLKTRTNAGRPNWD 1296
            .|..|| |.|: ||:..:::|.    .|....| ..||:.   ....|::||||.:|:.|||.||
Mouse   484 QEMEEL-GKMD-FLNYRLFLTG----WDSNIAG-HAALNF---DRATDILTGLKQKTSFGRPMWD 538

  Fly  1297 KVFKQL-QAQQKGKVTVFYCGPPQLAKTLRYKCDQYG--------FAFRKECF 1340
            ..|.:: .|..|..|.||.|||..|||:||.:|.:|.        |.|.||.|
Mouse   539 NEFSRIATAHPKSAVGVFLCGPRTLAKSLRKRCQRYSSLDPRKVQFYFNKETF 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008
		Ferric_reduct	560..700	CDD:280043	49/174 (28%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	34/74 (46%)
		FNR_like	<1136..>1178	CDD:297884	23/41 (56%)
		NAD_binding_6	1158..1325	CDD:285298	65/167 (39%)
Nox1	XP_006528578.1	Ferric_reduct	102..243	CDD:366815	42/159 (26%)
Nox1	XP_006528578.1	NOX_Duox_like_FAD_NADP	324..591	CDD:99783	121/609 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6684
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2880
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2122
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.900