DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and Nox3

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_945196.2	Gene:	Nox3 / 224480	MGIID:	2681162	Length:	568	Species:	Mus musculus

Alignment Length:	912	Identity:	196/912 - (21%)
Similarity:	282/912 - (30%)	Gaps:	449/912 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 FVTYLFFYITVNLCLFISRAIQYRASNGF----VII------ARACGQCLNFNCAWVLVLMLRHS 576
            ||..| .::.||..|||.....|.....|    ||:      |||...||||||..:|:.:.|:.
Mouse    13 FVVAL-LWLAVNAYLFIDTFFWYTEEEAFFYTRVILGSALAWARASAVCLNFNCMLILLPVSRNF 76

  Fly   577 LTYLRGRGLSSYLP----LDHHVYLHKLTGITISVLSLIHTIMHLFNFSIIVINDPNINAGHYTI 637
            ::.:||..:....|    ||.::..|||....|:|.|:||.:.||||..            .|.:
Mouse    77 ISLVRGTSVCCRGPWRRQLDKNLNFHKLVAYGIAVNSVIHIVAHLFNLE------------RYHL 129

  Fly   638 GEWLLTDRPGLFGLIP--GCA------NP-------------------TGVALLAILVVMFVCSQ 675
            |:  ..|..||...:.  |.|      ||                   ||:.:...||.:...|.
Mouse   130 GQ--AKDAEGLLAALSKLGDAPNESYLNPVRTFDMGTTTELLMTVSGITGLGISLALVFIMTSST 192

  Fly   676 PFVRRKGSFEVFYWTHLLYVPFWILCLFHG----------------------------------- 705
            .|:|| .|:|:|::||.::|.|:|....||
Mouse   193 EFIRR-SSYELFWYTHHIFVFFFISLAIHGGGRIIRGQTPESLRLHNVTYCRDHYAEWQAAALCP 256

  Fly   706 --------PNFWKWFLLPGLVYIVERALRFIWMRGEHGKTYISSGLLLPSKVVHLVIKRPHHFNF 762
                    |:.|||.|.|.::|..||.:|| |.  .|.:..|:..:..||.|:.|.:|: ..|..
Mouse   257 VPQFSGKEPSAWKWALGPVVLYACERIIRF-WR--SHQEVVITKVVSHPSAVLELHMKK-RDFKM 317

  Fly   763 RPGDYVFVNIPAIANYEWHPFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQ 827
            .||.|:|:..|:::..||||||::||| |||:..:|||..|:||..|
Mouse   318 APGQYIFIQCPSVSPLEWHPFTLTSAP-QEDFFSVHIRASGDWTEAL------------------ 363

  Fly   828 EIPQHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPI 892

Mouse   364 ----------------------------------------------------------------- 363

  Fly   893 DPPATGVNRIRSIKKTLQRTFSRKEAVDPKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDISV 957

Mouse   364 ----------------------------------------------------------------- 363

  Fly   958 KSKKRSRLKALRALGRSESESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFK 1022
                   |||.|..|::.||..
Mouse   364 -------LKAFRVEGQAPSELC------------------------------------------- 378

  Fly  1023 TPSMEEREHQVAAGEANGASPASRAEQGQLSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGSP 1087
                                                    .:.||:
Mouse   379 ----------------------------------------SMPRLA------------------- 384

  Fly  1088 SRKSILRRPTFLRSLSASINNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIF 1152
                                                                :|||:|...:.:|
Mouse   385 ----------------------------------------------------VDGPFGGSLADVF 397

  Fly  1153 GAQHAVLIGTGIGVTPFASILQSIMHRYWKARHSCPRCQFEWASEIPKSVMNLRKVDFFWINRDQ 1217
            ....:|.|.||||||||||:|:|:    |   :.|  |:       .:|:..|.||.|:||.||.
Mouse   398 HYPVSVCIATGIGVTPFASLLKSV----W---YKC--CE-------SQSLPELSKVYFYWICRDA 446

  Fly  1218 RSFEWFVNLLSQLEIEQAELGGAMERFLDMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLIT 1282
            .:||||.:||..||...:|.|.|  ..|..|:|:|.   ..:.:|:.:     .||.....|:||
Mouse   447 GAFEWFADLLLSLETRMSEQGKA--HLLSYHIYLTG---WDENQAIHI-----ALHWDESLDVIT 501

  Fly  1283 GLKTRTNAGRPNWDKVFKQLQAQQ-KGKVTVFYCGPPQLAKTLRYKCDQYG--------FAFRKE 1338
            |||.:...|||||:..|||:.... ...:.||:||...::|||:..|..|.        |.:.||
Mouse   502 GLKQKAFYGRPNWNDEFKQIAYNHPSSSIGVFFCGSKAMSKTLQKMCRLYSSVDPRGVHFYYNKE 566

  Fly  1339 CF 1340
            .|
Mouse   567 NF 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008
		Ferric_reduct	560..700	CDD:280043	49/170 (29%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	30/74 (41%)
		FNR_like	<1136..>1178	CDD:297884	19/41 (46%)
		NAD_binding_6	1158..1325	CDD:285298	64/167 (38%)
Nox3	NP_945196.2	Ferric_reduct	66..217	CDD:280043	44/165 (27%)
Nox3	NP_945196.2	NOX_Duox_like_FAD_NADP	295..568	CDD:99783	115/609 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6684
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2880
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870