DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and duox-2

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_490684.1	Gene:	duox-2 / 186188	WormBaseID:	WBGene00018771	Length:	1503	Species:	Caenorhabditis elegans

Alignment Length:	1202	Identity:	231/1202 - (19%)
Similarity:	396/1202 - (32%)	Gaps:	509/1202 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 LLQDRWIEHLKGRLTDDRQMD-FAEQIESVAYVICGENKRVSFKNFRD-IWHTRGI--------L 289
            ||..:...||..||:.||.:. |.:||...|   .|.|..|..|:..: |..::.|        |
Worm   715 LLSQKNNHHLVIRLSSDRDLSKFLDQIRQAA---SGINAEVIIKDEENSILLSQAITKERRQDRL 776

  Fly   290 DKLYRLIELDGSNLVSTNQVMEFISHLTNSRPRTGFDKSSLARLEQLFRTTVGNEQEIRREEFQK 354
            |..:|.......|          .|.|.:|  .|.||.|:    :.:...|      |.|||...
Worm   777 DLFFREAYAKAFN----------DSELQDS--ETSFDSSN----DDILNET------ISREELAS 819

  Fly   355 IVTSK-NPFFTERVFQIFDKDNSGSISLQEFIDAIHQFSGQSADDKIRFLFKVYDIDGDGLIQHK 418
            .:..| |..|.:|:|.:..|.|..|:|..||:..:.:|.......|::.|||:.|::|...:..|
Worm   820 AMGMKANNEFVKRMFAMTAKHNEDSLSFNEFLTVLREFVNAPQKQKLQTLFKMCDLEGKNKVLRK 884

  Fly   419 ELHDVIRHCIKENGMEFSEDQIEDLTSAMFEDADPHNSGEI---------TYEALKNQLHKHGGL 474
            :|.::::...:..|:..:    |.:...:|.|. .|.||..         .::||.:::..
Worm   885 DLAELVKSLNQTAGVHIT----ESVQLRLFNDV-LHKSGVSDDAEYLTCNNFDALFSEISD---- 940

  Fly   475 LENLSITIDR-------------WLVPIAEDRQAGGAAKSGFWNSLPHQFSL-----AYMKNNQV 521
            ::.:.:..:|             ...||.:             :|.|...||     |:::..:.
Worm   941 VQPIGLPFNRKNYNSHIKEPSCHTSFPIVD-------------HSTPAPLSLIQRICAFLETYRQ 992

  Fly   522 FVTYLFFYITVNLCLFI-----------SRAIQYRASNGFVIIARACGQCLNFNCAWVLVLMLRH 575
            .|..:|.::.:|:.||.           .|.::.....|..|...:.| .|:|..|.:|:.:.|:
Worm   993 HVFIIFCFVAINIVLFFELFWHSRYLNEDRDLRRVMGAGIAITLSSAG-ALSFCMALILLTVCRN 1056

  Fly   576 SLTYLRGRGLSSYLPLDHHVYLHKLTGITISVLSLIHTIMHLFNFSIIVINDPNINAGHYTIGEW 640
            .:|.||...::.|:|.|..:..||:..:.....|.:|||.|..||              |.:|
Worm  1057 IITLLRETVIAQYIPFDSAIAFHKIVALFTLFWSTLHTIGHCVNF--------------YHVG-- 1105

  Fly   641 LLTDR----------------PGL----FGLIPGCANPTGVALLAILVVMFVCSQP-FVRRKGSF 684
            ..:||                |.|    :|.|.|.   ||:.|:.::.:::|.:.| |.||  ::
Worm  1106 TQSDRGLACLFQETFFGSDVVPTLSYWFYGTITGL---TGIGLVIVMSIIYVFALPKFTRR--AY 1165

  Fly   685 EVFYWTHLLYVPFWILCLFHG-------PNFWKWFLLPGLVYIVERALRFIWMRGEHGKTY-ISS 741
            ..|..||||.:.|:.|.:.||       |.|..:.:.|.::::::|.:..:    ::.|:. |:.
Worm  1166 HAFRLTHLLNIGFYALTILHGLPSLFGSPKFGYYVVGPIVLFVIDRIIGLM----QYYKSLDIAH 1226

  Fly   742 GLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIA---NYEWHPFTISSAPEQEDYMWLHIRTVG 803
            ..:|||.::::..:||..|.::.|.::.|:.|:|:   | |.|.|:|:|:|:.|: |.|:|:.||
Worm  1227 AEILPSDIIYIEYRRPREFEYKSGQWITVSSPSISCTFN-ESHAFSIASSPQDEN-MKLYIKAVG 1289

  Fly   804 EWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAKN 868
            .||.:|
Worm  1290 PWTWKL----------------------------------------------------------- 1295

  Fly   869 LGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTFSRKEAVDPKKGIPNGAFIAD 933

Worm  1296 ----------------------------------------------------------------- 1295

  Fly   934 GEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSESESAFDEKRVRRARNNSVGLAYL 998
                                                   |||
Worm  1296 ---------------------------------------RSE----------------------- 1298

  Fly   999 SPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGASPASRAEQGQLSSRMDSADKLQ 1063

Worm  1299 ----------------------------------------------------------------- 1298

  Fly  1064 LARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSASINNRTGGGGGGSTGSSTTNSGGK 1128
                                              .:|||                     |:|..
Worm  1299 ----------------------------------LIRSL---------------------NTGSP 1308

  Fly  1129 VTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFASILQSIMHRYWKARHSCPRCQFE 1193
            ..|      |.:.||||..:......:.|:::|.||||||:||.|..::.:.........||
Worm  1309 FPL------IHMKGPYGDGNQEWMNYEVAIMVGAGIGVTPYASTLVDLVQKTSSDSFHRVRC--- 1364

  Fly  1194 WASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQLEIEQAELGGAMERFLDMHMYITSALQRT 1258
                        |||.|.|:....::|||||::|..:| .||:.|     .|:.|:::|....:.
Worm  1365 ------------RKVYFLWVCSSHKNFEWFVDMLKNVE-NQAKPG-----ILETHIFVTQMFHKF 1411

  Fly  1259 DMKAVGLQLALDLLHEKGKR------DLITGLKTRTNAGRPNWDKVFKQLQAQQK--GKVTVFYC 1315
            |::...|.:.     ||..|      .:.|||..:.:.||||:...|:.:|::.|  .::.||.|
Worm  1412 DLRTTMLYIC-----EKHFRATNSGISMFTGLHAKNHFGRPNFKAFFQFIQSEHKEQSEIGVFSC 1471

  Fly  1316 GPPQLAKTLRYKC-------DQYGFAFRKECF 1340
            ||..|.:::...|       |...||.|.|.|
Worm  1472 GPVNLNESIAEGCADANRQRDAPSFAHRFETF 1503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	41/161 (25%)
		EFh	365..425	CDD:238008	17/59 (29%)
		EFh	399..462	CDD:238008	15/71 (21%)
		Ferric_reduct	560..700	CDD:280043	43/160 (27%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	26/77 (34%)
		FNR_like	<1136..>1178	CDD:297884	16/41 (39%)
		NAD_binding_6	1158..1325	CDD:285298	51/174 (29%)
duox-2	NP_490684.1	An_peroxidase	39..552	CDD:281139
		dual_peroxidase_like	41..596	CDD:188652
		FRQ1	792..>895	CDD:227455	31/114 (27%)
		Ferric_reduct	1041..1182	CDD:280043	43/161 (27%)
		NOX_Duox_like_FAD_NADP	1224..1408	CDD:99783	72/518 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810