Protein Alignment Nox and duox-2

DIOPT Version :10

• Sequence 1: NP_611116.2
• Gene: Nox / 5740310
• FlyBaseID: FBgn0085428
• Length: 1340
• Species: Drosophila melanogaster
• Sequence 2: NP_490684.1
• Gene: duox-2 / 186188
• WormBaseID: WBGene00018771
• Length: 1503
• Species: Caenorhabditis elegans
• Alignment Length: 1202
• Identity: 231/1202 - (19%)
• Similarity: 396/1202 - (32%)
• Gaps: 509/1202 - (42%)

  Fly   235 LLQDRWIEHLKGRLTDDRQMD-FAEQIESVAYVICGENKRVSFKNFRD-IWHTRGI--------L 289
            ||..:...||..||:.||.:. |.:||...|   .|.|..|..|:..: |..::.|        |
 Worm   715 LLSQKNNHHLVIRLSSDRDLSKFLDQIRQAA---SGINAEVIIKDEENSILLSQAITKERRQDRL 776

  Fly   290 DKLYRLIELDGSNLVSTNQVMEFISHLTNSRPRTGFDKSSLARLEQLFRTTVGNEQEIRREEFQK 354
            |..:|.......|          .|.|.:|  .|.||.|:    :.:...|      |.|||...
 Worm   777 DLFFREAYAKAFN----------DSELQDS--ETSFDSSN----DDILNET------ISREELAS 819

  Fly   355 IVTSK-NPFFTERVFQIFDKDNSGSISLQEFIDAIHQFSGQSADDKIRFLFKVYDIDGDGLIQHK 418
            .:..| |..|.:|:|.:..|.|..|:|..||:..:.:|.......|::.|||:.|::|...:..|
 Worm   820 AMGMKANNEFVKRMFAMTAKHNEDSLSFNEFLTVLREFVNAPQKQKLQTLFKMCDLEGKNKVLRK 884

  Fly   419 ELHDVIRHCIKENGMEFSEDQIEDLTSAMFEDADPHNSGEI---------TYEALKNQLHKHGGL 474
            :|.::::...:..|:..:    |.:...:|.|. .|.||..         .::||.:::..
 Worm   885 DLAELVKSLNQTAGVHIT----ESVQLRLFNDV-LHKSGVSDDAEYLTCNNFDALFSEISD---- 940

  Fly   475 LENLSITIDR-------------WLVPIAEDRQAGGAAKSGFWNSLPHQFSL-----AYMKNNQV 521
            ::.:.:..:|             ...||.:             :|.|...||     |:::..:.
 Worm   941 VQPIGLPFNRKNYNSHIKEPSCHTSFPIVD-------------HSTPAPLSLIQRICAFLETYRQ 992

  Fly   522 FVTYLFFYITVNLCLFI-----------SRAIQYRASNGFVIIARACGQCLNFNCAWVLVLMLRH 575
            .|..:|.::.:|:.||.           .|.::.....|..|...:.| .|:|..|.:|:.:.|:
 Worm   993 HVFIIFCFVAINIVLFFELFWHSRYLNEDRDLRRVMGAGIAITLSSAG-ALSFCMALILLTVCRN 1056

  Fly   576 SLTYLRGRGLSSYLPLDHHVYLHKLTGITISVLSLIHTIMHLFNFSIIVINDPNINAGHYTIGEW 640
            .:|.||...::.|:|.|..:..||:..:.....|.:|||.|..||              |.:|
 Worm  1057 IITLLRETVIAQYIPFDSAIAFHKIVALFTLFWSTLHTIGHCVNF--------------YHVG-- 1105

  Fly   641 LLTDR----------------PGL----FGLIPGCANPTGVALLAILVVMFVCSQP-FVRRKGSF 684
            ..:||                |.|    :|.|.|.   ||:.|:.::.:::|.:.| |.||  ::
 Worm  1106 TQSDRGLACLFQETFFGSDVVPTLSYWFYGTITGL---TGIGLVIVMSIIYVFALPKFTRR--AY 1165

  Fly   685 EVFYWTHLLYVPFWILCLFHG-------PNFWKWFLLPGLVYIVERALRFIWMRGEHGKTY-ISS 741
            ..|..||||.:.|:.|.:.||       |.|..:.:.|.::::::|.:..:    ::.|:. |:.
 Worm  1166 HAFRLTHLLNIGFYALTILHGLPSLFGSPKFGYYVVGPIVLFVIDRIIGLM----QYYKSLDIAH 1226

  Fly   742 GLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIA---NYEWHPFTISSAPEQEDYMWLHIRTVG 803
            ..:|||.::::..:||..|.::.|.::.|:.|:|:   | |.|.|:|:|:|:.|: |.|:|:.||
 Worm  1227 AEILPSDIIYIEYRRPREFEYKSGQWITVSSPSISCTFN-ESHAFSIASSPQDEN-MKLYIKAVG 1289

  Fly   804 EWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAKN 868
            .||.:|
 Worm  1290 PWTWKL----------------------------------------------------------- 1295

  Fly   869 LGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTFSRKEAVDPKKGIPNGAFIAD 933
                                                                             
 Worm  1296 ----------------------------------------------------------------- 1295

  Fly   934 GEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRALGRSESESAFDEKRVRRARNNSVGLAYL 998
                                                   |||
 Worm  1296 ---------------------------------------RSE----------------------- 1298

  Fly   999 SPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAGEANGASPASRAEQGQLSSRMDSADKLQ 1063
                                                                             
 Worm  1299 ----------------------------------------------------------------- 1298

  Fly  1064 LARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLRSLSASINNRTGGGGGGSTGSSTTNSGGK 1128
                                              .:|||                     |:|..
 Worm  1299 ----------------------------------LIRSL---------------------NTGSP 1308

  Fly  1129 VTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIGVTPFASILQSIMHRYWKARHSCPRCQFE 1193
            ..|      |.:.||||..:......:.|:::|.||||||:||.|..::.:.........||
 Worm  1309 FPL------IHMKGPYGDGNQEWMNYEVAIMVGAGIGVTPYASTLVDLVQKTSSDSFHRVRC--- 1364

  Fly  1194 WASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQLEIEQAELGGAMERFLDMHMYITSALQRT 1258
                        |||.|.|:....::|||||::|..:| .||:.|     .|:.|:::|....:.
 Worm  1365 ------------RKVYFLWVCSSHKNFEWFVDMLKNVE-NQAKPG-----ILETHIFVTQMFHKF 1411

  Fly  1259 DMKAVGLQLALDLLHEKGKR------DLITGLKTRTNAGRPNWDKVFKQLQAQQK--GKVTVFYC 1315
            |::...|.:.     ||..|      .:.|||..:.:.||||:...|:.:|::.|  .::.||.|
 Worm  1412 DLRTTMLYIC-----EKHFRATNSGISMFTGLHAKNHFGRPNFKAFFQFIQSEHKEQSEIGVFSC 1471

  Fly  1316 GPPQLAKTLRYKC-------DQYGFAFRKECF 1340
            ||..|.:::...|       |...||.|.|.|
 Worm  1472 GPVNLNESIAEGCADANRQRDAPSFAHRFETF 1503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_611116.2	EFh_HEF	222..425	CDD:355006	54/200 (27%)
		EF-hand motif	290..316	CDD:320075	4/25 (16%)
		FRQ1	331..462	CDD:444056	32/140 (23%)
		EF-hand motif	351..388	CDD:320075	12/37 (32%)
		EFh	365..425	CDD:238008	17/59 (29%)
		EF-hand motif	402..425	CDD:320075	7/22 (32%)
		PLN02844	<544..>816	CDD:215453	81/303 (27%)
		FNR_like	<1136..>1178	CDD:447143	16/41 (39%)
		NAD_binding_6	1158..1325	CDD:429792	51/174 (29%)
duox-2	NP_490684.1	dual_peroxidase_like	41..596	CDD:188652
		PTZ00183	<811..>903	CDD:185503	26/101 (26%)
		COG4097	989..1405	CDD:443273	131/776 (17%)
		NOX_Duox_like_FAD_NADP	1224..1408	CDD:99783	72/518 (14%)