DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and Cybb

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_031833.3	Gene:	Cybb / 13058	MGIID:	88574	Length:	570	Species:	Mus musculus

Alignment Length:	909	Identity:	186/909 - (20%)
Similarity:	284/909 - (31%)	Gaps:	431/909 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 NNQVFVTYLFFYITVNLCLFISRAIQY----------RASNGFVIIARACGQCLNFNCAWVLVLM 572
            |..:.:..:..::.:|:.|||:....|          :.....:.:|||...||||||..:|:.:
Mouse     7 NEGLSIFVILVWLGLNVFLFINYYKVYDDGPKYNYTRKLLGSALALARAPAACLNFNCMLILLPV 71

  Fly   573 LRHSLTYLRGRG--LSSYL--PLDHHVYLHKLTGITISVLSLIHTIMHLFNFSIIVINDPNINAG 633
            .|:.|::|||..  .|:.:  .||.::..||:....|::.:.||||.||||....|    |...|
Mouse    72 CRNLLSFLRGSSACCSTRIRRQLDRNLTFHKMVAWMIALHTAIHTIAHLFNVEWCV----NARVG 132

  Fly   634 ---HYTIG-----------------EWLLTDRPGLFGLIPGCANPTGVALLAILVVMFVCSQPFV 678
               .|:|.                 |.:.....||:..:...|..||:.:...|:::...|...:
Mouse   133 ISDRYSIALSDIGDNENEEYLNFAREKIKNPEGGLYVAVTRLAGITGIVITLCLILIITSSTKTI 197

  Fly   679 RRKGSFEVFYWTHLLYVPFWILCLFHG------------------------------------PN 707
            || ..||||::||.|:|.|:|....||                                    |.
Mouse   198 RR-SYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLEEHNLDICADKIEEWGKIKECPVPK 261

  Fly   708 F-------WKWFLLPGLVYIVERALRFIWMRGEHGKTYISSGLLLPSKVVHLVIKRPHHFNFRPG 765
            |       |||.:.|..:|:.||.:|| |...:  |..|:..:..|.|.:.|.:|: ..|....|
Mouse   262 FAGNPPMTWKWIVGPMFLYLCERLVRF-WRSQQ--KVVITKVVTHPFKTIELQMKK-KGFKMEVG 322

  Fly   766 DYVFVNIPAIANYEWHPFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQEIP 830
            .|:||..|.::..||||||::|||| ||:..:|||.||:||..|:.....::|:.|.
Mouse   323 QYIFVKCPKVSKLEWHPFTLTSAPE-EDFFSIHIRIVGDWTEGLFNACGCDKQEFQD-------- 378

  Fly   831 QHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPP 895

Mouse   379 ----------------------------------------------------------------- 378

  Fly   896 ATGVNRIRSIKKTLQRTFSRKEAVDPKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSK 960

Mouse   379 ----------------------------------------------------------------- 378

  Fly   961 KRSRLKALRALGRSESESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPS 1025
                                                                       |:|.|
Mouse   379 -----------------------------------------------------------AWKLP- 383

  Fly  1026 MEEREHQVAAGEANGASPASRAEQGQLSSRMDSADKLQLARLSLSAEGASKPLEDQTQTGSPSRK 1090

Mouse   384 ----------------------------------------------------------------- 383

  Fly  1091 SILRRPTFLRSLSASINNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIFGAQ 1155
                                                          :|.:|||:|..|..:|..:
Mouse   384 ----------------------------------------------KIAVDGPFGTASEDVFSYE 402

  Fly  1156 HAVLIGTGIGVTPFASILQSIMHRYWKARHSCPRCQFEWASEIPKSVMNLRKVDFFWINRDQRSF 1220
            ..:|:|.|||||||||||:|:.::|      |...          :.:.|:|:.|:|:.||..:|
Mouse   403 VVMLVGAGIGVTPFASILKSVWYKY------CDNA----------TSLKLKKIYFYWLCRDTHAF 451

  Fly  1221 EWFVNLLSQLEIEQAELGGAMERFLDMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLITGLK 1285
            |||.:||..||.:..|...|  .||..::|:|...:.        |.....:|...::|:|||||
Mouse   452 EWFADLLQLLETQMQERNNA--NFLSYNIYLTGWDES--------QANHFAVHHDEEKDVITGLK 506

  Fly  1286 TRTNAGRPNWDKVFKQLQAQQKG-KVTVFYCGPPQLAKTLRYKC---DQYG-----FAFRKECF 1340
            .:|..||||||..||.:.::... .:.||.|||..||:||..:.   .:.|     |.|.||.|
Mouse   507 QKTLYGRPNWDNEFKTIASEHPNTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008
		Ferric_reduct	560..700	CDD:280043	50/163 (31%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	30/74 (41%)
		FNR_like	<1136..>1178	CDD:297884	21/41 (51%)
		NAD_binding_6	1158..1325	CDD:285298	61/167 (37%)
Cybb	NP_031833.3	Ferric_reduct	66..219	CDD:366815	45/157 (29%)
		PLN02844	<165..>423	CDD:215453	90/572 (16%)
		NOX_Duox_like_FAD_NADP	297..570	CDD:99783	110/609 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6684
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2880
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870