DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and Nox1

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	NP_446135.2	Gene:	Nox1 / 114243	RGDID:	620598	Length:	563	Species:	Rattus norvegicus

Alignment Length:	925	Identity:	200/925 - (21%)
Similarity:	287/925 - (31%)	Gaps:	464/925 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 YMKNNQVFVTYLFFYITVNLCLFISRAIQYRASNGF----------VIIARACGQCLNFNCAWVL 569
            ::.|:.:.|.:|..::.:|:.||:...:.|..|:.:          :.:|||...|||||...:|
  Rat     4 WLVNHWLSVLFLVSWLGLNIFLFVYVFLNYEKSDKYYYTREILGTALALARASALCLNFNSMVIL 68

  Fly   570 VLMLRHSLTYLRGRGLSSYL------PLDHHVYLHKLTGITISVLSLIHTIMHLFNF-------- 620
            :.:.|:.|::|  ||..|:.      ||||::..|||....|.:.:.||.|.|||||
  Rat    69 IPVCRNLLSFL--RGTCSFCNHTLRKPLDHNLTFHKLVAYMICIFTAIHIIAHLFNFERYSRSQQ 131

  Fly   621 -------SII--------------VINDPNINAGHYTIGEWLLTDRPGLFGLIPGCANPTGVALL 664
                   |::              .|..||:..               ::......|..|||...
  Rat   132 AMDGSLASVLSSLFHPEKEDSWLNPIQSPNVTV---------------MYAAFTSIAGLTGVVAT 181

  Fly   665 AILVVMFVCSQPFVRRKGSFEVFYWTHLLYVPFWILCL-FHG----------------------- 705
            ..||:|...:..|:|| ..||:|::||.|:: .:|:|| .||
  Rat   182 VALVLMVTSAMEFIRR-NYFELFWYTHHLFI-IYIICLGIHGLGGIVRGQTEESMSESHPRNCSY 244

  Fly   706 ---------------------PNFWKWFLLPGLVYIVERALRFIWMRGEHGKTYISSGLLLPSKV 749
                                 |..|||.|.|...||.||.|||...|   .|..|:..::.|.||
  Rat   245 SFHEWDKYERSCRSPHFVGQPPESWKWILAPIAFYIFERILRFYRSR---QKVVITKVVMHPCKV 306

  Fly   750 VHLVIKRPHHFNFRPGDYVFVNIPAIANYEWHPFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFE 814
            :.|.: |...|....|.|:|||.|:|:..||||||::|||| |::..:|||..|:||..|.|.||
  Rat   307 LELQM-RKRGFTMEIGQYIFVNCPSISFLEWHPFTLTSAPE-EEFFSIHIRAAGDWTENLIRTFE 369

  Fly   815 REQQKLQQSGSSQEIPQHMHAIPTPSFMLLNEARNPAIAGERSATPQTDFLAKNLGVQAVPPVRP 879
            :               ||
  Rat   370 Q---------------QH----------------------------------------------- 372

  Fly   880 PRQNRKPAPGAPIDPPATGVNRIRSIKKTLQRTFSRKEAVDPKKGIPNGAFIADGEREDSNLKQR 944

  Rat   373 ----------------------------------------------------------------- 372

  Fly   945 PLEKSISLPDISVKSKKRSRLKALRALGRSESESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSF 1009

  Rat   373 ----------------------------------------------------------------- 372

  Fly  1010 RYMRTKPTIIAFKTPSMEEREHQVAAGEANGASPASRAEQGQLSSRMDSADKLQLARLSLSAEGA 1074
                                            ||..|.|
  Rat   373 --------------------------------SPMPRIE-------------------------- 379

  Fly  1075 SKPLEDQTQTGSPSRKSILRRPTFLRSLSASINNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIF 1139

  Rat   380 ----------------------------------------------------------------- 379

  Fly  1140 IDGPYGAPSSHIFGAQHAVLIGTGIGVTPFASILQSIMHRYWKARHSCPRCQFEWASEIPKSVMN 1204
            :|||:|..|..:|..:.|||:|.|||||||||.|:||.:::.:|.:.                :.
  Rat   380 VDGPFGTVSEDVFQYEVAVLVGAGIGVTPFASFLKSIWYKFQRAHNK----------------LK 428

  Fly  1205 LRKVDFFWINRDQRSFEWFVNLLSQLEIEQAELGGAMERFLDMHMYITSALQRTDMKAVGLQLAL 1269
            .:|:.|:||.|:..:|.||.|||:.||.|..|||  ...||:..:::|.    .|....| ..||
  Rat   429 TQKIYFYWICRETGAFAWFNNLLNSLEQEMDELG--KPDFLNYRLFLTG----WDSNIAG-HAAL 486

  Fly  1270 DLLHEKGKRDLITGLKTRTNAGRPNWDKVFKQL-QAQQKGKVTVFYCGPPQLAKTLRYKCDQYG- 1332
            :.   ....|::||||.:|:.|||.||..|.:: .|..|..|.||.||||.|||:||..|.:|.
  Rat   487 NF---DRATDVLTGLKQKTSFGRPMWDNEFSRIATAHPKSVVGVFLCGPPTLAKSLRKCCRRYSS 548

  Fly  1333 -------FAFRKECF 1340
                   |.|.||.|
  Rat   549 LDPRKVQFYFNKETF 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455
		EFh	365..425	CDD:238008
		EFh	399..462	CDD:238008
		Ferric_reduct	560..700	CDD:280043	48/174 (28%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	34/74 (46%)
		FNR_like	<1136..>1178	CDD:297884	22/41 (54%)
		NAD_binding_6	1158..1325	CDD:285298	64/167 (38%)
Nox1	NP_446135.2	Ferric_reduct	74..217	CDD:396386	42/161 (26%)
		NOX_Duox_like_FAD_NADP	296..563	CDD:99783	120/609 (20%)
		Interaction with NOXO1. /evidence=ECO:0000250	396..535		62/164 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6296
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2859
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.870