DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nox and nox5

DIOPT Version :9

Sequence 1:	NP_001097336.1	Gene:	Nox / 5740310	FlyBaseID:	FBgn0085428	Length:	1340	Species:	Drosophila melanogaster
Sequence 2:	XP_017947981.2	Gene:	nox5 / 100491600	XenbaseID:	XB-GENE-1010931	Length:	774	Species:	Xenopus tropicalis

Alignment Length:	1022	Identity:	364/1022 - (35%)
Similarity:	511/1022 - (50%)	Gaps:	265/1022 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 DKSSLARLEQLFRTTVGNEQEIRREEFQKIVTSKNPFFTERVFQIFDKDNSGSISLQEFIDAIHQ 390
            |...|..:.:.|....|:::||..|||:..:..|..||.||.|.:||.|.||||||.|.:.|::.
Frog    11 DSKWLEWVTKQFENIAGDDKEIDLEEFKTALKVKESFFAERFFALFDSDGSGSISLDELLKALNL 75

  Fly   391 FSGQSADDKIRFLFKVYDIDGDGLIQHKELHDVIRHCIKENGMEFSEDQIEDLTSAMFEDADPHN 455
            ....:..||:||||:|||:||.|.|...||..|::.|::|:.:...|::::|||..:||.||..:
Frog    76 LIHGNETDKLRFLFQVYDVDGSGSIDPSELRTVLKSCLRESAISLPEEKLDDLTLVLFESADKDH 140

  Fly   456 SGEITYEALKNQLHKHGGLLENLSITIDRWLVPIAEDRQAGGAAKSGFWNSLPHQFSLAYMKNNQ 520
            ||.||::.||.:|.:...::|||:|:...||.|.|...:          :..|...:..|..||:
Frog   141 SGSITFQELKEELERFPEVMENLTISAANWLKPPAVQNK----------SHTPRYLTRTYWHNNR 195

  Fly   521 VFVTYLFFYITVNLCLFISRAIQYRASNGFVIIARACGQCLNFNCAWVLVLMLRHSLTYLRGRGL 585
            ..:.::..|..:|:.||...|:.:.:..|::::|:.|||||||||.:::|:|||..||:||...:
Frog   196 SKLLFMCCYWCLNVLLFGLAAVNHASLGGWIMVAKGCGQCLNFNCTFIVVMMLRRCLTWLRTTCV 260

  Fly   586 SSYLPLDHHVYLHKLTGITISVLSLIHTIMHLFNFSIIVINDPNIN----AGHYTIGEWLLTDRP 646
            ..:||||.:|.||:|.|..|.||::|||..|:.||         ||    .|.||..|:|||.||
Frog   261 VRFLPLDQNVVLHELIGYVIFVLTVIHTAAHITNF---------INLTEKTGAYTFWEYLLTIRP 316

  Fly   647 GLFGLIPGCANPTGVALLAILVVMFVCSQPFVRRKGSFEVFYWTHLLYVPFWILCLFHGPNFWKW 711
            |: |.|.|.|:.||:.|..::.:|.:.|..|||:.|.|||||||||.|:..|||...|.|.||||
Frog   317 GI-GWISGTASITGILLQLLICLMLLFSNTFVRKGGYFEVFYWTHLSYIWIWILLFLHTPKFWKW 380

  Fly   712 FLLPGLVYIVERALRFIWMRGEHGKTYISSGLLLPSKVVHLVIKRPHHFNFRPGDYVFVNIPAIA 776
            ||:|||::::|:.......|  .|..||:...||.|||.|||||||..|.|:||||:::|||.||
Frog   381 FLVPGLLFLLEKLFGAAVSR--TGDVYITEVNLLASKVTHLVIKRPPSFQFKPGDYIYLNIPVIA 443

  Fly   777 NYEWHPFTISSAPEQEDYMWLHIRTVGEWTNRLYRYFEREQQKLQQSGSSQEIPQHMHAIPTPSF 841
            .||||||||||||||.|.:|||||::|:|||.||.||.
Frog   444 KYEWHPFTISSAPEQADTIWLHIRSLGQWTNSLYEYFH--------------------------- 481

  Fly   842 MLLNEARNPAIAGERSATPQTDFLAKNLGVQAVPPVRPPRQNRKPAPGAPIDPPATGVNRIRSIK 906
                             .|||                                    |||
Frog   482 -----------------NPQT------------------------------------VNR----- 488

  Fly   907 KTLQRTFSRKEAVDPKKGIPNGAFIADGEREDSNLKQRPLEKSISLPDISVKSKKRSRLKALRAL 971

Frog   489 ----------------------------------------------------------------- 488

  Fly   972 GRSESESAFDEKRVRRARNNSVGLAYLSPQNKSLAQSFRYMRTKPTIIAFKTPSMEEREHQVAAG 1036
                                                    ..||..|:..|......:||..::|
Frog   489 ----------------------------------------HETKRQILTQKNRQHHSQEHLFSSG 513

  Fly  1037 EANGASPASRAEQGQLSSRMDSADKL-QLARLSLSAEGASKPLEDQTQTGSPSRKSILRRPTFLR 1100
            ....|..::..:|.:|:|.....:.| :..|:||...|:::..|
Frog   514 HICEAIASNDDDQIELTSYRPRRNPLGEEVRVSLDGTGSAQGQE--------------------- 557

  Fly  1101 SLSASINNRTGGGGGGSTGSSTTNSGGKVTLDAGVMEIFIDGPYGAPSSHIFGAQHAVLIGTGIG 1165
             :....|:          ..|..|           ::.:||||||.|:..||.:.||||||.|||
Frog   558 -ICCMAND----------NQSLCN-----------IKCYIDGPYGTPTRRIFTSDHAVLIGAGIG 600

  Fly  1166 VTPFASILQSIMHRYWKARHSCPRCQFEWASEIPKSVMNLRKVDFFWINRDQRSFEWFVNLLSQL 1230
            :|||||||||||:||...:.:||.||:.|...:.::.|:||||||.||||||:.|||||:||::|
Frog   601 ITPFASILQSIMYRYRMRKQNCPSCQYSWCETLKENEMDLRKVDFIWINRDQKFFEWFVSLLTKL 665

  Fly  1231 EIEQA--ELGGAMERFLDMHMYITSALQRTDMKAVGLQLALDLLHEKGKRDLITGLKTRTNAGRP 1293
            |::||  |..|   |||:||||:||||.:.||||:|||:|||||.:|.|:|.||||:|||..|||
Frog   666 ELDQADEEPDG---RFLEMHMYMTSALSKNDMKAIGLQMALDLLAQKEKKDSITGLRTRTQPGRP 727

  Fly  1294 NWDKVFKQLQAQQKGKVTVFYCGPPQLAKTLRYKCDQYGFAFRKECF 1340
            :|:|||::::.:.||||.||:||.|.|||.::..|:::.|.|.||.|
Frog   728 DWNKVFQKIEQENKGKVQVFFCGSPALAKIIKAHCEKFNFKFFKENF 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nox	NP_001097336.1	FRQ1	314..466	CDD:227455	57/139 (41%)
		EFh	365..425	CDD:238008	30/59 (51%)
		EFh	399..462	CDD:238008	29/62 (47%)
		Ferric_reduct	560..700	CDD:280043	68/143 (48%)
		NOX_Duox_like_FAD_NADP	744..>819	CDD:99783	51/74 (69%)
		FNR_like	<1136..>1178	CDD:297884	28/41 (68%)
		NAD_binding_6	1158..1325	CDD:285298	103/168 (61%)
nox5	XP_017947981.2	FRQ1	<32..151	CDD:227455	52/118 (44%)
		PLN02631	<290..>480	CDD:178238	106/201 (53%)
		NOX_Duox_like_FAD_NADP	406..690	CDD:99783	150/519 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2568
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41568
Inparanoid	1	1.050	689	1.000	Inparanoid score	I680
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D936110at2759
OrthoFinder	1	1.000	-	-		FOG0011972
OrthoInspector	1	1.000	-	-		oto104999
Panther	1	1.100	-	-	LDO	PTHR11972
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9808
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160