Protein Alignment CG41520 and ANGPTL1

DIOPT Version :10

• Sequence 1: NP_001104019.1
• Gene: CG41520 / 5740294
• FlyBaseID: FBgn0087011
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_004664.1
• Gene: ANGPTL1 / 9068
• HGNCID: 489
• Length: 491
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 142/524 - (27%)
• Similarity: 221/524 - (42%)
• Gaps: 128/524 - (24%)

  Fly   283 HCAVVHHNNQFKF--LNVTTHSKSNNINKLVKEIRPMGVVSEQNDNVWDVGVDTKSTDGHLLSKS 345
            ||    ...|||.  :|...:.::.:..:..|:.....:|.||. ....:.|:||..|...:...
Human    20 HC----RGGQFKIKKINQRRYPRATDGKEEAKKCAYTFLVPEQR-ITGPICVNTKGQDASTIKDM 79

  Fly   346 TAPL------SQTQRQERAID----------EIHHDKK--PKSYLNINN------FDMVKKQFEK 386
            ...:      ....||:|.||          .|.::.|  .|...|:|:      ..::.:...|
Human    80 ITRMDLENLKDVLSRQKREIDVLQLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRK 144

  Fly   387 QENFKPPEEISE----------------TRIKEALEYESKNYTDTDENSRTEILLLSL------- 428
            ::|   ..|:|:                ||.:| ||.:..:.||...|....|.||..
Human   145 RDN---SLELSQLENKILNVTTEMLKMATRYRE-LEVKYASLTDLVNNQSVMITLLEEQCLRIFS 205

  Fly   429 ---SNIQPTIVNKTITTPFTSTPGDGDVLGPLHSESLDSNRTHYNGPAVNGLKSANR-----KDR 485
               :::.|.:|.                :.|.|.    .|...|. |.:.|.....|     :|.
Human   206 RQDTHVSPPLVQ----------------VVPQHI----PNSQQYT-PGLLGGNEIQRDPGYPRDL 249

  Fly   486 IIFPSIKKKP----------AFLNTTISNDFWALKDVKGFSCVDILNAGMKQSGVFYLQIRGTTY 540
            :..|.:...|          .|:|.....|           |.....||...||::.::...:.
Human   250 MPPPDLATSPTKSPFKIPPVTFINEGPFKD-----------CQQAKEAGHSVSGIYMIKPENSN- 302

  Fly   541 WFLKVYCDQETTDGGWTVIQRRDDFKDSRENFNRDWADYKNGFGEPSKDFWLGNENIYMLTNNEE 605
            ..::::|:.....|||||||:|   .|...||.|:|.:||.|||....::|||.||||||:|.:.
Human   303 GPMQLWCENSLDPGGWTVIQKR---TDGSVNFFRNWENYKKGFGNIDGEYWLGLENIYMLSNQDN 364

  Fly   606 YSLRVELEDFEGNKRYAQYSHFKIHSEADYYKLEIDGYEGNAGDSLNDPWYGSNNSPFSTYNKDN 670
            |.|.:||||:...|.||:||.|::..|:::|:|.:..|:||||||:  .|:  |...|:|.::|.
Human   365 YKLLIELEDWSDKKVYAEYSSFRLEPESEFYRLRLGTYQGNAGDSM--MWH--NGKQFTTLDRDK 425

  Fly   671 DRSSLNCASMLKGGWWWKSCGR-GLNGL------YLHDPQDITARQGIVWFRWRGWDYTLKKSKM 728
            |..:.|||...|||||:.:|.. .|||:      |....||     ||.|..:||..|:|:..:|
Human   426 DMYAGNCAHFHKGGWWYNACAHSNLNGVWYRGGHYRSKHQD-----GIFWAEYRGGSYSLRAVQM 485

  Fly   729 MIRP 732
            ||:|
Human   486 MIKP 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG41520	NP_001104019.1	FReD	516..733	CDD:238040	88/224 (39%)
ANGPTL1	NP_004664.1	PB1	74..138	CDD:413452	10/63 (16%)
		FReD	275..490	CDD:238040	89/239 (37%)