Protein Alignment CG41520 and TNXB

DIOPT Version :10

• Sequence 1: NP_001104019.1
• Gene: CG41520 / 5740294
• FlyBaseID: FBgn0087011
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_001415264.1
• Gene: TNXB / 7148
• HGNCID: 11976
• Length: 4491
• Species: Homo sapiens
• Alignment Length: 415
• Identity: 125/415 - (30%)
• Similarity: 184/415 - (44%)
• Gaps: 91/415 - (21%)

  Fly   347 APLSQTQRQERAIDEIHHDKKPKSYLNINNFDMVKKQFEKQENFKPPEEISETRIKEA-LEYESK 410
            ||..|.:....|:|...||    ..|:.|....|:..  :..|...|..|:.|...|| .:.|:|
Human  4131 APPLQAETPGSAVDYPLHD----LVLHTNYTATVRGL--RGPNLTSPASITFTTGLEAPRDLEAK 4189

  Fly   411 NYTDTDENSRTEILLLSLSNIQPTIVNKTITTPFTST-----PG---DGDVLGPLHSESLDSNRT 467
            ..|     .||.:|..:...::|.....:..||....     ||   ...:||...|       |
Human  4190 EVT-----PRTALLTWTEPPVRPAGYLLSFHTPGGQNQEILLPGGITSHQLLGLFPS-------T 4242

  Fly   468 HYNG-----------PAVN------GLKSANRKDRIIFPSIKKKPAFLNTTISNDFWALKDVKGF 515
            .||.           |.|:      ||       ||.||.
Human  4243 SYNARLQAMWGQSLLPPVSTSFTTGGL-------RIPFPR------------------------- 4275

  Fly   516 SCVDILNAGMKQSGVFYLQIRGTTYWFLKVYCDQETTDGGWTVIQRRDDFKDSRENFNRDWADYK 580
            .|.:.:..|...|....:.:.|.....|.|:||.||..|||.|.|||   .|.:.:|.|||.||.
Human  4276 DCGEEMQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRR---MDGQTDFWRDWEDYA 4337

  Fly   581 NGFGEPSKDFWLGNENIYMLTNNEEYSLRVELEDFEGNKR-YAQYSHFKIHSEADYYKLEIDGYE 644
            :|||..|.:||||||.::.||...:||:||:|.  .|::. :|||..|.:.|.|:||:|.::||.
Human  4338 HGFGNISGEFWLGNEALHSLTQAGDYSMRVDLR--AGDEAVFAQYDSFHVDSAAEYYRLHLEGYH 4400

  Fly   645 GNAGDSLNDPWYGSNNSPFSTYNKDNDRSSLNCASMLKGGWWWKSCG-RGLNGLYLHDPQDITAR 708
            |.||||::   |.| .|.||..::|.:...::||...:|.||:::|. ..|||||    ......
Human  4401 GTAGDSMS---YHS-GSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLY----GSTVDH 4457

  Fly   709 QGIVWFRWRGWDYTLKKSKMMIRPR 733
            ||:.|:.|:|:::::..::|.:|||
Human  4458 QGVSWYHWKGFEFSVPFTEMKLRPR 4482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG41520	NP_001104019.1	FReD	516..733	CDD:238040	82/218 (38%)
TNXB	NP_001415264.1	C_rich_MXAN6577	<191..295	CDD:469225
		EGF_Tenascin	249..275	CDD:480934
		PTZ00214	<254..669	CDD:173479
		EGF_Tenascin	311..337	CDD:480934
		C_rich_MXAN6577	314..418	CDD:469225
		EGF_Tenascin	373..399	CDD:480934
		EGF_Tenascin	559..585	CDD:480934
		EGF_Tenascin	719..745	CDD:480934
		fn3	762..831	CDD:394996
		fn3	843..919	CDD:394996
		fn3	1114..1161	CDD:394996
		fn3	1308..1388	CDD:394996
		FN3	1403..1485	CDD:238020
		fn3	1512..1589	CDD:394996
		fn3	1623..1693	CDD:394996
		FN3	<1673..2048	CDD:442628
		FN3	2020..2109	CDD:238020
		fn3	2132..2202	CDD:394996
		fn3	2235..2308	CDD:394996
		fn3	2346..2416	CDD:394996
		fn3	2445..2515	CDD:394996
		fn3	2551..2624	CDD:394996
		FN3	<2665..>2895	CDD:442628
		fn3	2773..2843	CDD:394996
		fn3	2876..2956	CDD:394996
		fn3	2990..3057	CDD:394996
		fn3	3092..3172	CDD:394996
		fn3	3206..3273	CDD:394996
		fn3	3308..3381	CDD:394996
		FN3	3384..>3762	CDD:442628
		fn3	3809..3884	CDD:394996
		fn3	3903..3985	CDD:394996
		fn3	4005..4083	CDD:394996
		FN3	<4061..>4251	CDD:442628	33/137 (24%)
		fn3	4182..4259	CDD:394996	18/88 (20%)
		Fibrinogen_C	4273..4482	CDD:395095	84/246 (34%)