DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Not1 and Cnot1

DIOPT Version :9

Sequence 1:	NP_001286252.1	Gene:	Not1 / 5740252	FlyBaseID:	FBgn0085436	Length:	2511	Species:	Drosophila melanogaster
Sequence 2:	XP_006530933.1	Gene:	Cnot1 / 234594	MGIID:	2442402	Length:	2383	Species:	Mus musculus

Alignment Length:	2587	Identity:	1197/2587 - (46%)
Similarity:	1593/2587 - (61%)	Gaps:	306/2587 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ALILASKPYAMQLFDSKPYITDSIYDILQFVKEHGLEADRSSLRHLFSVINFS-DLVPSVTVQLQ 75
            :|.|:...|.:.....|.| ..|..:|...|..||.||||..||.|||.::|| |...|.....|
Mouse     7 SLALSQISYLVDNLTKKNY-RASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQ 70

  Fly    76 AKLLGIQLERQLHSSSFVSNICYAFDQFFASNQKQSLKPVAVADLVGQVARLTGINKVCECVFAL 140
            .:.|..:....:...:|:|.:.||.|.  ..:.::||||  ...|..|::::..::||.|.:|.|
Mouse    71 TQFLIQECASLITKPNFISTLSYAIDN--PLHYQKSLKP--APHLFAQLSKVLKLSKVQEVIFGL 131

  Fly   141 ALTHSSYTELKHSARNNLKGSLSELIDSYLGNKGTGPADSGLREISFDLLQYLLCCL-------S 198
            ||.:||..:|:..|...:|..|.:|:.||:....:|..:.|.::|:.::|..||..|       .
Mouse   132 ALLNSSSPDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAF 196

  Fly   199 EYVQPQVEAQFLIKLREEFPRQAVPLVLAPFLYGSTTATIAGAGASETDAEAEATTNSNSSSFEA 263
            ...|.|::| ||..||.:||::..|:||||.||
Mouse   197 GVGQEQIDA-FLKTLRRDFPQERCPVVLAPLLY-------------------------------- 228

  Fly   264 DALNEVGIEDIYDHLSEIIFTNQG--KNNIMDTSWINLILEIGYEFTSSVEECKNHLCS---RER 323
                    .:..|.|.:.|..:.|  ...:|::|..:.:.|:||.|.:|:|||:|.:..   ||.
Mouse   229 --------PEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIMQFGVREV 285

  Fly   324 ERAELQSKDVAKIVGLMCRRHSSLLDCNVNLPTPANFWPGQGQGGGSNSSGSSQTQITPQQQNPG 388
            ..|:     ||:::|:|.|.||.|.|   .:|..:...||.|
Mouse   286 TAAQ-----VARVLGMMARTHSGLTD---GIPLQSISAPGSG----------------------- 319

  Fly   389 SSNNNDGSDGNSSSDKKDKKETTEATQTWKPDVFVQALKEVVPQLNWKDVCMELDHPEFVLKDRI 453
                       ..||.|||.|..:| .||..:|.:..|||:.|.||:|:|..|||||.|.::|..
Mouse   320 -----------IWSDGKDKSEGAQA-HTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSK 372

  Fly   454 GLELLLTILRLATGSNIFPHPECIYRHWANTEGQLSLIATMLKNPDLFSFADFVFSQPALDVLKT 518
            ||..::..::...|..:|| .:.|||.|.:.|||||.|...|.||::|.|||:.....|.|:||.
Mouse   373 GLHNVVYGIQRGLGMEVFP-VDFIYRPWKHAEGQLSFIQHSLINPEVFCFADYPCHTVATDILKA 436

  Fly   519 APDADNKEISSWKSLHLVEVLLSIADKGYYTQVHELFKFPAQNCPDVLFLALLNTSPPMTPLRQD 583
            .|:.||:||::||||.|:|.||.:|:.|.|.||.:||.||.::|||:|.||||..:.....||.:
Mouse   437 PPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHE 501

  Fly   584 LFNQLIPTFLGNHPNSNVILASAW--SSNNFQLRSNIMNAMSEWYLRGNEFDQVKLSRILDLAQD 646
            |.:.|:|.||||||||.:||..||  ...:..:|..||:||:|||:||.::||.|||||||:|||
Mouse   502 LISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQD 566

  Fly   647 LKALSALLNARSFLFIIDLACLASRREYLKLEKWLTDKIREHGEPFMQAIIKVLHRRCPQVINAK 711
            |||||.|||...|.|:||||.||||||||||:||||||||||||||:||.:..|.||||.::...
Mouse   567 LKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGL 631

  Fly   712 VPE-DQLPPKQAQLLPETVTTMINCLQTCINNCMQPEMVEVIMQMTANVAIMANKARAQQQQQPG 775
            .|| ||  ||.|||..||:.||:.|||.|..:..| |:.|.|:.|.||.:.:.||||   |..||
Mouse   632 APEKDQ--PKSAQLPAETLATMLACLQACAGSVSQ-ELSETILTMVANCSNVMNKAR---QPPPG 690

  Fly   776 LVP---PP---------PPTI--LRGHRGMDLPGGIVP--------PP--------PQQPFSGNL 810
            ::|   ||         |..|  |.|...:.:.|...|        ||        ||.|
Mouse   691 VMPKGRPPSASSLDAISPVQIDPLAGMASLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSP----- 750

  Fly   811 NAQMFGPGMDP-LTNMSNNLAGLNLSGPNGAFNFGNML-TSPSRLMTPGANPYPLNLMQMPQAPP 873
             |:.|.|...| .|...:.:.||:...|.|....|::. .....|..|..|..|.
Mouse   751 -AKAFPPLSTPNQTTAFSGIGGLSSQLPVGGLGTGSLTGIGTGALGLPAVNNDPF---------- 804

  Fly   874 PPNVGNLGRML-PGGPQQQTPTPTPTAPNPNNPVMADLQIPVSKEVEDEVNSYFQRIYNHQPNPT 937
                  :.|.| ..|..|.|...:...|:..:.|..:.....|||::||.||||||||||.|:||
Mouse   805 ------VQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPT 863

  Fly   938 LSIDEVLDILQRFKESSNRREQEVFLCMLRNLFEEYRFFCQYPEKELQITAQLFGGIIDRNLVPT 1002
            :|:||||::|||||:|:.:||:|||.|||||||||||||.|||:|||.|||.||||||::.|| |
Mouse   864 MSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLV-T 927

  Fly  1003 FVALGLSLRCVLDALRKPDGSKLYYFGVTALDRFRTRLHTYNKYCEHIRSIPHFSDFPPHLIQYV 1067
            ::||||:||.||:|||||.|||:||||:.|||||:.||..|.:||:|:.||.||..||.||.:|:
Mouse   928 YMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYI 992

  Fly  1068 EYGMHGQEPPPQKLIGLSNTIPSAISSGPGTEPIYRNSSMLGNMPAATPGSGPKSNAAVSHATR- 1131
            |||...:: ||.|:.| |.|.|.:|:        ...:.....:||..|.:| :.|..|:.:|.
Mouse   993 EYGQQSRD-PPVKMQG-SITTPGSIA--------LAQAQAQAQVPAKAPLAG-QVNTMVTTSTTT 1046

  Fly  1132 --MKSIA-----------------NATNIDTLLVA-NQEEKVTVPPEPVQDKTAFIFNNLSQLNI 1176
              .|::.                 |.||||||||| :|.|::..|||.:|:|.|||||||||.|:
Mouse  1047 TVAKTVTVTKPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNM 1111

  Fly  1177 PQKCDEIKEIMTKEYWPWLAQYLVLKRASMEFNFHTLYYNFLDALKNGEINRFVTKETLRNIKVL 1241
            .||.:|:||.:.:|:.||::||||:||.|:|.|||:||.||||.|||.|.|:.|..||.||||||
Mouse  1112 TQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVL 1176

  Fly  1242 LRSDKGVINFSDRSLLKNLGHWLGMMTLGRNRPILQLDLDLKSLLAEAYHKGQQELLFVVPFVAK 1306
            |.|||...|||||||||||||||||:||.:|:|||..|||:||||.|||.|||||||:|||||||
Mouse  1177 LTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAK 1241

  Fly  1307 ILESSAKSRIFRSPNPWTMGIMYVLAELHQEPDLKLNLKFEIEVLCKTLNLELAKLRQVIYLKDP 1371
            :||||.:|.:||.||||||.||.||||||||.|||||||||||||||.|.|::.:|:....|||.
Mouse  1242 VLESSIRSLVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDK 1306

  Fly  1372 NRTHRIEEQMSQPKPKQLEPVASAPALPREQQSPAQPPPPPQQQQPPQQQVPPPPSSADVDAQNA 1436
            :|...::||:|.||....:|          ::.||
Mouse  1307 DRLKNLDEQLSAPKKDVKQP----------EELPA------------------------------ 1331

  Fly  1437 AAMMMAAGGANSTPGSVSSPNLPTDSSQVALPPPEPRYSYVDVNVSNFQLIGQQLVLPPNTPFLH 1501
                :.....::||.        |.::..|..||:|:|||.|:||.:...:...:.|.|..|...
Mouse  1332 ----ITTTTTSTTPA--------TSTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQ 1384

  Fly  1502 ANPGIKHMVVNAVERTITDWLQPIVDRSIRIACATTEQIIRKDFALDADENRMRTAAHQMVRNLA 1566
            |:|.:|..|..|:||.:.:.:.|:|||||:||..|.|||:|||||||::|:|||.|||.|:|||.
Mouse  1385 AHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLT 1449

  Fly  1567 AGMAMITGKDEIARAISQNLHKALLSGL-NGMPSMAEI--QAAAMQLASENVELVCAFIQKTSAE 1628
            |||||||.::.:..:||.||..:..|.| ...|...|:  |||| |||.:|.||.|.|||||:.|
Mouse  1450 AGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAA-QLAQDNCELACCFIQKTAVE 1513

  Fly  1629 KAAAEIDRRLSTDFETRKIAREEGNRFVDAQILTYQQERLPEAVRIKVGAAPATLYAVYSEFARS 1693
            ||..|:|:||:|:||.||.||:||.|:.|..:||||.||:||.:|:|||.......|||.||||:
Mouse  1514 KAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARN 1578

  Fly  1694 IPGFQQMSDRDIALFVPKPTD-LSQP--NVFANDD-SMVYGELASKMEAFMNTAIGVPTLQI--Q 1752
            :|||...:|      :.:||. |:||  ..:|.|| :.:|.:..:::|..::..  .|||.:  |
Mouse  1579 VPGFLPTND------LSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAI--PPTLAMNPQ 1635

  Fly  1753 ASKMHMLLNALIATRRLRDQESAFNLLTRAVEGLTEGLVNMHENMEQMKMYQNIHLRILGLLNN- 1816
            |..:..||..::.:|..||..:|..||.:|||||.:.......::  :..|:..||.:|..|.:
Mouse  1636 AQALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADL--LLRYRECHLLVLKALQDG 1698

  Fly  1817 -SFGAPNTERAVTKCFFDIREEVRYNVEAARALITSHFVNLNQFDGMLRDCMDNGNNYVAISFGI 1880
             ::|:|...:.:|:|..:.|:|.:|||||...||.:|.||:.|:|..|...|:||.||:|::|.:
Mouse  1699 RAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAM 1763

  Fly  1881 ALLERLIMDDRVINIVSDNEFMATVELLGRLTQH-RHRYPECIVNAIDTLWSGNFNSSSDYSPFN 1944
            .|::.|::|:|.:..:::.:...|:|.|.|:..| |...||.:...::.:.| |:.:..
Mouse  1764 QLVKILLVDERSVAHITEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRS-NYEAMI------ 1821

  Fly  1945 GNDRYLSGASHYIHSGMHHVRSCDTDDPPGLQEKTEFLLKDWVALYTQQNQQSTRDA-RNFGAFV 2008
              ||...|.:..:|||:.  ::.:.||||||:||.|:||::||.||  .:..:.||: :.|.|||
Mouse  1822 --DRAHGGPNFMMHSGIS--QASEYDDPPGLREKAEYLLREWVNLY--HSAAAGRDSTKAFSAFV 1880

  Fly  2009 -------QKMNTYGILKTDDLITRFFRQATHICTDVVYRMFAE----PSLPINQAKNKIFQWIDA 2062
                   :||:..||||||||||||||..|.:|.::.||..||    |:......:.|.:..:||
Mouse  1881 GQVELLERKMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDA 1945

  Fly  2063 FVHLIAMLVRHSGEAGNPTTKINLLNKVLGIVLGTLIKDHEMRGVSFQQVGYHRFFMMLFMELCT 2127
            ||.|||:||:|||||.|..|||||||||||||:|.|::||::|...|||:.|||.|:||.:||..
Mouse  1946 FVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNA 2010

  Fly  2128 ADVILESLMHSIVSAFAYTYHLLNPSVAPGFCFAWLELISHRVFLGRILVQIPGQKGWPLYAQLL 2192
            .:.:||::....::||..|:|:|.|:.||||.:|||||||||:|:.|:|...|.|||||:|||||
Mouse  2011 PEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLL 2075

  Fly  2193 QDLFKYLAPFLRNTELGKPVQLLYKGTLRVLLVLLHDFPEFLCDYHFGFCDTIPPNCVQMRNIIL 2257
            .||||||||||||.||.||:|:||||||||||||||||||||||||:||||.|||||:|:||:||
Mouse  2076 IDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLIL 2140

  Fly  2258 SAFPRNMRLPDPFTPNLKVDMLSDSSNAPKVLSSYIMNIQPANFKKDLDSYLKARAPVTFLSELR 2322
            |||||||||||||||||||||||:.:.||::|::: ..:.|..||||||||||.|:||||||:||
Mouse  2141 SAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNF-TGVMPPQFKKDLDSYLKTRSPVTFLSDLR 2204

  Fly  2323 GHLQVTSEPGTRYNMALMNALVMYVGTQAIALIRNKNFVPNTSNIAHSAHMDIFQNLAVDLDTEG 2387
            .:|||::|||.|||:.|:||||:||||||||.|.||...|:.|.|.|||||||||||||||||||
Mouse  2205 SNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEG 2269

  Fly  2388 RYLFLNAIANQLRYPNSHTHYFSCAVLHLFAEANSEAIQEQITRVLLERLIVNRPHPWGLLITFI 2452
            ||||||||||||||||||||||||.:|:||||||:||||||||||||||||||||||||||||||
Mouse  2270 RYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFI 2334

  Fly  2453 ELIKNPIYKFWDHDFVHCAPEITKLFESVARSCLAKSNVTQQLNMPVVDGEG 2504
            ||||||.:|||:|:||||||||.|||:|||:.|:.:....|     |::|.|
Mouse  2335 ELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQ-----VMEGTG 2381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Not1	NP_001286252.1	CNOT1_HEAT	582..737	CDD:293027	96/157 (61%)
		CNOT1_TTP_bind	906..1079	CDD:293026	110/172 (64%)
		CNOT1_CAF1_bind	1155..1373	CDD:293024	149/217 (69%)
		DUF3819	1506..1649	CDD:289602	78/145 (54%)
		Not1	2129..2478	CDD:281978	263/348 (76%)
Cnot1	XP_006530933.1	CNOT1_HEAT	500..656	CDD:374533	96/157 (61%)
Cnot1	XP_006530933.1	CDC39	<840..2376	CDD:227434	857/1629 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846158
Domainoid	1	1.000	571	1.000	Domainoid score	I231
eggNOG	1	0.900	-	-		E1_COG5103
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9453
Inparanoid	1	1.050	2045	1.000	Inparanoid score	I49
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54022
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003737
OrthoInspector	1	1.000	-	-		oto95236
orthoMCL	1	0.900	-	-		OOG6_101511
Panther	1	1.100	-	-	LDO	PTHR13162
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R833
SonicParanoid	1	1.000	-	-		X2594
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790