DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Not1 and let-711

DIOPT Version :9

Sequence 1:	NP_001286252.1	Gene:	Not1 / 5740252	FlyBaseID:	FBgn0085436	Length:	2511	Species:	Drosophila melanogaster
Sequence 2:	NP_498516.3	Gene:	let-711 / 175971	WormBaseID:	WBGene00002845	Length:	2641	Species:	Caenorhabditis elegans

Alignment Length:	2737	Identity:	853/2737 - (31%)
Similarity:	1307/2737 - (47%)	Gaps:	508/2737 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LEADRS-SLRHLFSVINFSDLVPSVTVQLQAKLLGIQLERQLHSSSFVSNICYAF----DQFFAS 106
            ||.|.: ||.|  :::::|    :||   |....||::......:|.:.::.||:    |...||
Worm   113 LEEDAALSLFH--TILSYS----TVT---QINRSGIEILGAQRLTSALCDLIYAYTKTMDDMVAS 168

  Fly   107 NQKQSL--------KPVAVADLVGQVARLTGINKVCECVFALALTHSSYTE------------LK 151
            .....|        .|:.|...:.::|:...:....:.:|   |.|..||.            ..
Worm   169 KTLTHLCKKLAGLFDPLVVLPFISKLAKSRRLRHYLQPLF---LGHCEYTSDTWGVSPEGAEIYN 230

  Fly   152 HSARNNL-KGSLSELIDSYLGNKGTGPADSGLREI-------SFDLLQYLLCCL----SEYVQPQ 204
            ..||.|. ..:|.|::.::|        :..::|:       ...|:|||:.|.    :|.||
Worm   231 QIARGNFTTQTLIEIVQTFL--------EKEVKEVIISSTTDPIKLVQYLISCSNPDNTEIVQ-- 285

  Fly   205 VEAQFLIKLREEFPRQAVPLVLAPFLYGSTTATIAGAGASETDAEAEATTNSNSSSFEADALNEV 269
                                .||..||.:|....||:|.: .|.:.:|          ||.:...
Worm   286 --------------------ALAFLLYSNTKLLPAGSGGT-IDMDVQA----------ADTITTA 319

  Fly   270 GIEDIYDHLSEIIFTNQGKNNIMDTSWINLI--LEI-GYEFTSSVEECKNHLCSRERERAELQSK 331
                   .|.:..||...|:.::|:....|:  :|| |....||||.....|.....::..:.:.
Worm   320 -------RLGDTKFTQPVKDALLDSGREALLRRMEIYGVSLLSSVENFVTELKQAPIQKKMVTNN 377

  Fly   332 DVAKIVGLMCRRHSSL-LDCNVNLPTPANFWPGQGQGGGSNSSGSSQTQITPQQQNPGSSNNNDG 395
            .||..:..|.:.:..: .|........:.||      ||||.. ...|:...:||
Worm   378 SVANAILYMLQYNFDMSRDIENGRQDNSPFW------GGSNFV-IGITRFVEEQQ---------- 425

  Fly   396 SDGNSSSDKKDKKETTEATQTWKPDVFVQALKEVVPQLNWKDVCMELDHPEFVLKDRIGLELLLT 460
                  :..:|    .|....|.||:            ||.:|..|.|..||.:..:       |
Worm   426 ------AAVRD----MEGFSDWYPDI------------NWVEVIKEFDSEEFAICRQ-------T 461

  Fly   461 ILRLATGSNIFP---HPE-----CIYRHWANTEGQLSLIATMLKNPDLFSFADFVFSQ---PALD 514
            |:..|   :|||   .|:     .....|...:.||.|...|::..|:::.:.:..::   |.|:
Worm   462 IIMFA---DIFPIMFQPQNFPVSFFLTPWRYYDHQLRLFEFMIEYADVWNISQYPHTKVLTPDLN 523

  Fly   515 VLKTAPDADNKEISSWKSLHLVEVLLSIADK--GYYTQVHELFKFPAQNCPDVLFLALLNTSPPM 577
             |||.||.....:..|........||:||:.  ..|..:.:.:...:....||..|||:.:....
Worm   524 -LKTIPDDSTSVVQLWNCQEFSNCLLTIANSQPSLYNAIKQFYNVGSMQAGDVSMLALILSPTQW 587

  Fly   578 TPLRQDLFNQLIPTFLGNHPNSNVILASAWSSNNF--QLRSNIMNAMSEWYLRGNEFDQVKLSRI 640
            |..||||....:|:|:...||...:|...|:..:.  .:|.:::..::..:..    |..:|::|
Worm   588 TTGRQDLIRHFLPSFILKSPNVTPVLNLVWNDTSLSKHMRQHVIYCLTSMHAA----DSSQLAKI 648

  Fly   641 LDLAQDLK--ALSALLN--ARSFLFIIDLACLASRREYLKLEKWLTDKIREHGEPFMQAIIKVLH 701
            ||:|.|:|  .||.|||  .:...|::|||||||:|:||.||||:.||.:.|||....|:::.:.
Worm   649 LDVAHDIKPTGLSELLNQAPKHLAFMVDLACLASKRDYLNLEKWIEDKEKAHGEAMTVAVLQFIQ 713

  Fly   702 RRC--PQVINAKVPEDQLPPKQAQLLPETVTTMINCLQTCINNCMQ---PEMVEVIMQMTANVAI 761
            ::.  .|::.|..|:.|.....|.  .|.:..:|..:.......::   |.:.:|:.:.:...:.
Worm   714 KKYQHAQLVAAIAPKTQATTPGAP--SEPLQVLIPFVSKRARKPLRQQFPLVFQVMKENSGRSSS 776

  Fly   762 MANKARAQQ-------------------------QQQPGLVP-----------PPPPTILRG--H 788
            :::....||                         ||||...|           |.|||..:.  |
Worm   777 VSSGGHVQQSSGSQPQQQQFGGGSGLPPSGVVPVQQQPQQPPSLQQQHSQQSLPTPPTTSQQQIH 841

  Fly   789 RGMDLPGGIVPP---------PPQ------------QPFSGNLNAQMFGPGMDPLTNMS-----N 827
            ....:||.|..|         |||            ||...:.|||   |||:.|.|||     |
Worm   842 VQQSVPGPIQRPAQFAPQPMFPPQAQAQHQHQHMMGQPPPSSQNAQ---PGMNLLMNMSPFASGN 903

  Fly   828 NLAGLNLSGPNGAFNFGNMLTSPSRLMTPG----------------------ANPYPLNLMQMPQ 870
            |...|.:..|         ...|...|:|.                      |.|.|    |.|.
Worm   904 NRDLLKVVQP---------APPPPSSMSPSTQMMRSLIPPLTQRQNSNSGWHAAPAP----QRPS 955

  Fly   871 APPPPNV-----GNLGRMLPGGPQQ-----------------------QTPTPTP--------TA 899
            .||.|..     |.:....|.||.|                       ....|.|        .|
Worm   956 GPPTPQQQMDFRGQIQEFAPQGPHQLQRSGSVTGRSMGIVGQKTSSNFSVGAPIPGSAAATAAAA 1020

  Fly   900 PNPNNPVMADLQ-IPVSKEVEDEVNSYFQRIYNHQPNPTLSIDEVLDILQRFKESSNRREQEVFL 963
            .|...|:..|.| :..::::::|.||||::||:  .|..:|::.::|:|:||:.|::|||:.|..
Worm  1021 ANVQQPMNEDFQSMTFAEDIQEEANSYFEKIYS--VNNAMSVENLIDLLKRFRVSNDRRERLVLA 1083

  Fly   964 CMLRNLFEEYRFFCQYPEKELQITAQLFGGIIDRNLVPTFVALGLSLRCVLDALRKPDGSKLYYF 1028
            |:::|||||||||.:|||:||:.||.::||||..:::.. |....::|.|:::|.....:.|:.|
Worm  1084 CVVKNLFEEYRFFHEYPERELRTTAAVYGGIIREDIISN-VQFATAVRKVIESLSADPNTMLWTF 1147

  Fly  1029 GVTALDRFRTRLHTYNKYCEHIRSIPHFSDFPPHLIQYVEYGMHGQEPPPQKLIGLSNTIPSAIS 1093
            |:.||...|::|..|.|.|:.|.|..:|:.||..|..||..|:.|:.||..   |....:.||.:
Worm  1148 GIVALQHCRSKLCAYPKVCQMIVSSENFARFPQLLKDYVIAGVKGELPPEG---GRHTPVGSAQA 1209

  Fly  1094 SGPGTEPIYRNSSMLGNMPAATPGSGPKSNAAVSH-----------ATRMKSIANATNIDTLLVA 1147
            ....:.|              ||.:.|.:..||:.           |.|..::.:.||:|||::|
Worm  1210 GSASSTP--------------TPAAAPTNWGAVARAASVDPKNSLPANRTGNVLSYTNVDTLVMA 1260

  Fly  1148 NQEE--KVTVPPEPVQDKTAFIFNNLSQLNIPQKCDEIKEIMTKE---YWPWLAQYLVLKRASME 1207
            ..::  ::..|.|.:.||.:|:||||||.|:.||.||:.|:::..   :..|||||:|:||.|:|
Worm  1261 TNKDGAEIAQPAEAIVDKISFLFNNLSQSNLIQKKDEVVEMISDHGDAFTLWLAQYIVMKRVSIE 1325

  Fly  1208 FNFHTLYYNFLDALKNGEINRFVTKETLRNIKVLLRSDKGVI---NFSDRSLLKNLGHWLGMMTL 1269
            .||..||..|::|::|..:::.:.:||.|||::|||:||...   |:|||.||||||.|||.:|:
Worm  1326 QNFQPLYNQFVNAIENPYLDQCIKRETFRNIRILLRTDKRTTVASNYSDRQLLKNLGSWLGAITI 1390

  Fly  1270 GRNRPILQLDLDLKSLLAEAYHKGQQELLFVVPFVAKILESSAKSRIFRSPNPWTMGIMYVLAEL 1334
            .||:|||..||||||||.|||:|||.|||:||||::|||.:.:|:.:|.....|...|:.|||||
Worm  1391 ARNKPILLNDLDLKSLLLEAYYKGQAELLYVVPFISKILTACSKTSLFTPTCAWIRSILKVLAEL 1455

  Fly  1335 HQEPDLKLNLKFEIEVLCKTLNLELAKLRQVIYLKDPNRTHRIEEQMSQPK----PKQLEPVAS- 1394
            |.|||||:|||||||||||.||::|.:|:....|||..:..|:.:|:...|    |:...||.|
Worm  1456 HNEPDLKINLKFEIEVLCKELNVDLNQLQMDGILKDTEKLVRVPQQLCDVKLLTRPEAASPVQSK 1520

  Fly  1395 -------------APALPREQQSPAQPPPPPQQQQPPQQQVPPPPSSADVDAQNAAAMMMAAGGA 1446
                         :||:| :|..||.|.|                        ..|.:....||.
Worm  1521 IHMSGSAEQLSGMSPAIP-DQVKPATPQP------------------------TEAELQSGTGGG 1560

  Fly  1447 NSTPGSVSSPNLPTDSSQVALPPPEPRYSYVDVNVSNFQLIGQQLVLPPNTPFLHANPGIKHMVV 1511
            .|            ..::..:.|....::|.|:||..:..:...:.:..:.|....:|..||:|.
Worm  1561 GS------------QGAEAQVVPNVTHFAYHDINVLTYDGLIPHVKIVSHLPLFQLHPHAKHLVR 1613

  Fly  1512 NAVERTITDWLQPIVDRSIRIACATTEQIIRKDFALDADENRMRTAAHQMVRNLAAGMAMITGKD 1576
            .|:...|.:.:.|:.:|:::||...||.::|||||||.:|..:|.|:..|:|.:.|||||||.:|
Worm  1614 PAMIHAIKELIGPVTERALKIAMTVTESLVRKDFALDPEEQNLRAASFHMMRAMTAGMAMITCRD 1678

  Fly  1577 EIARAISQNLHKALLSGLNGM---PSMAE-IQAAAMQLASENVELVCAFIQKTSAEKAAAEIDRR 1637
            .:|.::..||..|..|.|...   |.|.: |:.||..:..:||||...||.||:.|||..:|::|
Worm  1679 PLASSMHSNLANAFSSSLRSTAANPEMKQMIEDAAATITQDNVELSTNFIVKTACEKATQDIEKR 1743

  Fly  1638 LSTDFETRKIAREEGNRFVDAQILTYQQERLPEAVRIKVGAAPATLYAVYSEFARSIPGFQQMSD 1702
            |..|::.|..|:.|.:.:.| :|......:||:|:....|.....|..:|.:|:..|.||:..|.
Worm  1744 LEADYQKRIAAKAEMSFYRD-EIAAAIHAQLPKAIATVPGPTDKALMGIYDQFSSRICGFKANSG 1807

  Fly  1703 RDIALFVPKPTDLSQPNVFANDDSMVYGELASKMEAFMNTAIGVPTLQIQASK----MHMLLNAL 1763
            .|.....|....::.....:.:..:|..:|...::....|....|.|...|.:    |..|:..:
Worm  1808 EDPVSAEPGSGAITPVQTQSKEMELVCQQLQVIIKEVDQTTQAQPHLSNSAFQTVCLMRELMQNV 1872

  Fly  1764 IATRRLRDQESAFNLLTRAVEGLTEGLVNMHE----------NMEQMKMYQNIHLRILGLLNNSF 1818
            |:|   :|......|:||:    ||.|::.:.          ::|..:..:::.:.::.||.|.|
Worm  1873 IST---KDANHLMILVTRS----TEHLLHAYRLEGTPPKNLLDVEWARRLRDLFIGLMRLLQNYF 1930

  Fly  1819 GAPNTERAVTKCFFDIREEVRYNVEAARALITSHFVNLNQFDGMLRDCMDNGNNYVAISFGIALL 1883
            ......|.:|.....||.:.::|:|....|...:.:....:|..|...||||.|..|:.|.
Worm  1931 PLVELSRRITTAIMQIRSDYKWNMEGIEILFKQNLLQSVLWDQHLAGSMDNGGNMEAVLFA---- 1991

  Fly  1884 ERLIMDDRVINIVSDNEFMATVELLGRLTQHRHRYP-EC-IVNAIDTLWSGNFNSSSDYSPFNGN 1946
                  .:.:..:...: |:.::.|      :.|:| .| .:..:..|.|.......:.:..||
Worm  1992 ------QKFVRSIGGGD-MSRIQFL------KERFPLTCEQLTKLHQLQSATRTEGMNNAMNNG- 2042

  Fly  1947 DRYLSGASHYIHSGMHH------------VRSCDTD-------DPPGLQEKTEFLLKDWVAL-YT 1991
               ...|:|: |:|:..            :.....|       |...:..|.|.::::|:.| |:
Worm  2043 ---AGNAAHH-HAGLQQQPPVALPMEAAPMPQASADAMAQRGYDDQEMTAKVEIIMREWIGLCYS 2103

  Fly  1992 QQNQQSTRDARNFGAFVQKMNTYGILKTDDLITRFFRQATHICTDVVYRMFAEP----SLPINQA 2052
            ...|:|.::  :....:|.|:.:|:|.|||.||:|||.....|.|:..|:....    .||....
Worm  2104 PTGQRSPQE--SLAQMIQLMHEHGVLATDDKITQFFRLCVENCVDISVRVMKSEQLANGLPTTLI 2166

  Fly  2053 KNKIFQWIDAFVHLIAMLVRHSGEAGNPTTKINLLNKVLGIVLGTLIKDHEMRGVSFQQVGYHRF 2117
            :::.:..:||||.|:|:::||| :.|....|||||.|:|.|::|.|..|||:|...|..:.|||.
Worm  2167 RHRCYYTLDAFVKLMALMIRHS-DNGQSQNKINLLKKLLNIIVGVLHMDHEVRKQDFNAMPYHRI 2230

  Fly  2118 FMMLFMELCTAD--VILESLMHSIVSAFAYTYHLLNPSVAPGFCFAWLELISHRVFLGRILVQ-- 2178
            .:.||.|:...|  .:||.:..||:.||..|:..|.|...|||.||||:::.||..:||:|..
Worm  2231 LISLFNEITGPDPLKLLEPIAWSILEAFGQTFFALQPRRMPGFAFAWLDIVGHRNVIGRLLANTG 2295

  Fly  2179 ----IPGQKGWPLYAQLLQDLFKYLAPFLRNTELGKPVQLLYKGTLRVLLVLLHDFPEFLCDYHF 2239
                :...|....|.||:....|:|||||||.:|.|.:.:|||||||||||:||||||.||::|:
Worm  2296 IAETVDAVKTAATYTQLIISHLKFLAPFLRNIQLPKSIAILYKGTLRVLLVILHDFPELLCEFHY 2360

  Fly  2240 GFCDTIPPNCVQMRNIILSAFPRNMRLPDPFTPNLK-VDMLSDSSNAPKVLSSYIM-NIQPANFK 2302
            ..||||||||||:||:||||:||.|||||||..|.| ||.:.:.:..||  |:..| .|.|.|.:
Worm  2361 VICDTIPPNCVQLRNLILSAYPRQMRLPDPFALNFKQVDTIPEMAVEPK--SNLNMATIIPDNIR 2423

  Fly  2303 KDLDSYLKARAPVTFLSELRGHLQVTSEPGTRYNMALMNALVMYVGTQAIALIRNKNFVPNTSNI 2367
            ..||.||..|..|.||..|...||..::.||:||..:|||||:|||.:||..:..:....:|.||
Worm  2424 IPLDEYLANRISVDFLPNLPTLLQTQNQAGTKYNTTVMNALVLYVGIRAIEHLHLRRQRISTLNI 2488

  Fly  2368 AHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCAVLHLFAEANSEAIQEQITRV 2432
            ||:::||||||||:.||||||||..|.|||||||||:|||||||..|:||..:.::.|||||||:
Worm  2489 AHTSYMDIFQNLAIQLDTEGRYLLFNGIANQLRYPNAHTHYFSCVFLYLFKNSTNDTIQEQITRI 2553

  Fly  2433 LLERLIVNRPHPWGLLITFIELIKNPIYKFWDHDFVHCAPEITKLFESVARSCLAKSNVTQQLNM 2497
            |.|||:..||||||||||||||||||.|.||.::|..|||||.:||::||.:|     |..|.:.
Worm  2554 LFERLVALRPHPWGLLITFIELIKNPTYNFWRYEFTSCAPEIQRLFQNVANTC-----VPAQGSQ 2613

  Fly  2498 PVVDGEG 2504
            |....:|
Worm  2614 PQAQPDG 2620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Not1	NP_001286252.1	CNOT1_HEAT	582..737	CDD:293027	51/162 (31%)
		CNOT1_TTP_bind	906..1079	CDD:293026	67/173 (39%)
		CNOT1_CAF1_bind	1155..1373	CDD:293024	120/223 (54%)
		DUF3819	1506..1649	CDD:289602	58/146 (40%)
		Not1	2129..2478	CDD:281978	196/358 (55%)
let-711	NP_498516.3	CNOT1_HEAT	592..743	CDD:374533	50/156 (32%)
		PHA03378	<832..990	CDD:223065	43/173 (25%)
		CDC39	<1035..2602	CDD:227434	609/1658 (37%)
		Not1	2242..2599	CDD:367787	196/358 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164158
Domainoid	1	1.000	396	1.000	Domainoid score	I383
eggNOG	1	0.900	-	-		E1_COG5103
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9453
Inparanoid	1	1.050	1116	1.000	Inparanoid score	I116
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54022
OrthoDB	1	1.010	-	-		D42530at2759
OrthoFinder	1	1.000	-	-		FOG0003737
OrthoInspector	1	1.000	-	-		oto18260
orthoMCL	1	0.900	-	-		OOG6_101511
Panther	1	1.100	-	-	LDO	PTHR13162
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R833
SonicParanoid	1	1.000	-	-		X2594
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800