DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Not1 and cnot1

DIOPT Version :9

Sequence 1:NP_001286252.1 Gene:Not1 / 5740252 FlyBaseID:FBgn0085436 Length:2511 Species:Drosophila melanogaster
Sequence 2:NP_001090658.1 Gene:cnot1 / 100036630 XenbaseID:XB-GENE-1032888 Length:2388 Species:Xenopus tropicalis


Alignment Length:2587 Identity:1193/2587 - (46%)
Similarity:1590/2587 - (61%) Gaps:301/2587 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 ALILASKPYAMQLFDSKPYITDSIYDILQFVKEHGLEADRSSLRHLFSVINFS-DLVPSVTVQLQ 75
            :|.|:...|.:.....|.|....: :|...|..||.||||..||.|||.::|| |...|.....|
 Frog     7 SLALSQISYLVDNLTKKNYRASQL-EIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQ 70

  Fly    76 AKLLGIQLERQLHSSSFVSNICYAFDQFFASNQKQSLKPVAVADLVGQVARLTGINKVCECVFAL 140
            .:.|..:....:...:|:|.:.||.|.  ..:.::||||  ...|..|::::..::||.|.:|.|
 Frog    71 TQFLIQECASLITKPNFISTLSYAIDN--PLHYQKSLKP--SPHLFAQLSKVLKLSKVQEVIFGL 131

  Fly   141 ALTHSSYTELKHSARNNLKGSLSELIDSYLGNKGTGPADSGLREISFDLLQYLLCCL-------S 198
            ||.:||..||:..|...:|..|.:|:.||:....:|..:.|.::|:.::|..||..|       .
 Frog   132 ALLNSSSCELRGFAAQFVKQKLPDLLRSYVDVDVSGSQEGGFQDIAIEVLHLLLSNLLFGQKGAF 196

  Fly   199 EYVQPQVEAQFLIKLREEFPRQAVPLVLAPFLYGSTTATIAGAGASETDAEAEATTNSNSSSFEA 263
            ...|.|:.| ||..||.:||::..|:||||.||                                
 Frog   197 GVGQEQIVA-FLKTLRRDFPQERCPVVLAPLLY-------------------------------- 228

  Fly   264 DALNEVGIEDIYDHLSEIIFTNQG--KNNIMDTSWINLILEIGYEFTSSVEECKNHLCS-RERER 325
                    .:..|.|.:.|..:.|  ...:||:|..:.:.|:||.|.:|||||:|.:.. ..||.
 Frog   229 --------PEKRDILMDRILADSGGITKTMMDSSLADFMQEVGYSFCASVEECRNVIVQFGVREV 285

  Fly   326 AELQSKDVAKIVGLMCRRHSSLLDCNVNLPTPANFWPGQGQGGGSNSSGSSQTQITPQQQNPGSS 390
            ..:|   ||:::|:|.|.||.|.|                        |.....||    :|||.
 Frog   286 TAVQ---VARVLGMMARTHSGLTD------------------------GIPLQSIT----SPGSG 319

  Fly   391 NNNDGSDGNSSSDKKDKKETTEATQTWKPDVFVQALKEVVPQLNWKDVCMELDHPEFVLKDRIGL 455
            ..:||         |||.:..: ..||..:|.:..:||:.|.||:|:|..|||:|.|.::|..||
 Frog   320 IWSDG---------KDKNDAVQ-PHTWNVEVLIDVVKELNPTLNFKEVTYELDNPSFQIRDSKGL 374

  Fly   456 ELLLTILRLATGSNIFPHPECIYRHWANTEGQLSLIATMLKNPDLFSFADFVFSQPALDVLKTAP 520
            :.::..::...|...|| .:.:||.|.|.|||||.|...|.|||:|.|||:.....|.|:||..|
 Frog   375 QTVVYGIQRGLGIEAFP-VDLVYRPWKNAEGQLSFIQHSLVNPDVFCFADYACHAVATDILKAPP 438

  Fly   521 DADNKEISSWKSLHLVEVLLSIADKGYYTQVHELFKFPAQNCPDVLFLALLNTSPPMTPLRQDLF 585
            :.||:||::||||.|:|.||.:|:.|.|.||.:||.:|.::|||:|.||||..:.....||.:|.
 Frog   439 EDDNREIATWKSLDLIESLLRLAELGQYEQVKQLFAYPIKHCPDMLVLALLQINTTWHTLRHELI 503

  Fly   586 NQLIPTFLGNHPNSNVILASAW--SSNNFQLRSNIMNAMSEWYLRGNEFDQVKLSRILDLAQDLK 648
            :.|:|.||||||||.:||..||  ...:..:|..||:||:|||:||.::||.:||||||:|||||
 Frog   504 STLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQARLSRILDVAQDLK 568

  Fly   649 ALSALLNARSFLFIIDLACLASRREYLKLEKWLTDKIREHGEPFMQAIIKVLHRRCPQVINAKVP 713
            |||.|||...|.|:||||.||||||||||:||||||||||||||:||.:..|.||||.::....|
 Frog   569 ALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAP 633

  Fly   714 E-DQLPPKQAQLLPETVTTMINCLQTCINNCMQPEMVEVIMQMTANVAIMANKARAQQQQQPGLV 777
            | ||  ||.|||.|||:.||:.|||.|..:..| |:.|.|:.|.||.:.:.||||          
 Frog   634 EKDQ--PKSAQLPPETLATMLACLQACAGSVSQ-ELSETILTMVANCSNVVNKAR---------- 685

  Fly   778 PPPPPTILRGHRGMDLPGGIVPPPPQQPFSGNLNAQMFGP-GMDPLTNMSNNLAGLNLSGPNGAF 841
             .|||.::              |..:.|.:.:|:|  ..| .:||:..|    |.|::.|.    
 Frog   686 -QPPPGVM--------------PKGRPPSTSSLDA--ISPVQIDPIAAM----ASLSIGGS---- 725

  Fly   842 NFGNMLTSPSRLMTPGANPYPLNL---MQMPQAP----PP---PN-------VGNLGRMLPGG-- 887
                  .:|.....|   .:|.||   ...||:|    ||   ||       :|.|...||||  
 Frog   726 ------AAPHTQSMP---VFPPNLGSAFSTPQSPAKAFPPLTAPNQSTAFSGLGGLTSQLPGGLG 781

  Fly   888 --------------------PQQQTPTPTPTAPNPN------NPVMADLQIPVSKEVEDEVNSYF 926
                                |..|....|.....|.      :.|..:.....|||::||.||||
 Frog   782 TGSLTGMGTGGLSLPTVNSDPFGQRKLSTSGLNQPTFQQTDLSQVWPEANQHFSKEIDDEANSYF 846

  Fly   927 QRIYNHQPNPTLSIDEVLDILQRFKESSNRREQEVFLCMLRNLFEEYRFFCQYPEKELQITAQLF 991
            |||||..|:||:|:||||::|||||:|:.:||:|||.|||||||||||||.|||:|||.|||.||
 Frog   847 QRIYNQPPHPTMSVDEVLEMLQRFKDSNIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLF 911

  Fly   992 GGIIDRNLVPTFVALGLSLRCVLDALRKPDGSKLYYFGVTALDRFRTRLHTYNKYCEHIRSIPHF 1056
            ||||::.|| |::||||:||.||:|||||..||:|:||:.|||||:.||..|.:||:|:.||.||
 Frog   912 GGIIEKGLV-TYMALGLALRYVLEALRKPYQSKMYFFGIAALDRFKNRLKDYPQYCQHLASISHF 975

  Fly  1057 SDFPPHLIQYVEYGMHGQEPPPQKLIGLSNTIPSAISSGPGTEPIYRNSSMLGNMPAATPGSGPK 1121
            ..||.||.:|:|||...:: ||.|:.| |.|.|.:|:......|....||.....|..|.   |.
 Frog   976 MQFPHHLQEYIEYGQQSRD-PPVKMQG-SITTPGSIALSQAQTPAKPASSSAVTTPTTTT---PA 1035

  Fly  1122 SNAAVSHATRM---KSI---ANATNIDTLLVANQ-EEKVTVPPEPVQDKTAFIFNNLSQLNIPQK 1179
            ....::..|.:   |.:   .|.|||||||||.. ..::..|||.||:|.|||||||||.|:.||
 Frog  1036 KTITITRPTGVSFKKDVPPSINTTNIDTLLVATDLAGQIVEPPENVQEKIAFIFNNLSQSNMTQK 1100

  Fly  1180 CDEIKEIMTKEYWPWLAQYLVLKRASMEFNFHTLYYNFLDALKNGEINRFVTKETLRNIKVLLRS 1244
            .:|:||.:..:|.||::||||:||.|:|.|||:||.|||||||:.|.|:.|..||.|||||||.|
 Frog  1101 VEELKETVKDDYMPWVSQYLVMKRVSIELNFHSLYSNFLDALKHLEFNKMVLAETYRNIKVLLTS 1165

  Fly  1245 DKGVINFSDRSLLKNLGHWLGMMTLGRNRPILQLDLDLKSLLAEAYHKGQQELLFVVPFVAKILE 1309
            ||...|||||||||||||||||:||.:|:|||..||||||||.|||.|||||||:|||||||:||
 Frog  1166 DKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDLKSLLLEAYVKGQQELLYVVPFVAKVLE 1230

  Fly  1310 SSAKSRIFRSPNPWTMGIMYVLAELHQEPDLKLNLKFEIEVLCKTLNLELAKLRQVIYLKDPNRT 1374
            ||.:|.:||.||||||.||.||||||||.|||||||||||||||.|.|::..|:....|||.:|.
 Frog  1231 SSVRSVVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLVLDINDLKPGTLLKDKDRL 1295

  Fly  1375 HRIEEQMSQPKPKQLEPVASAPALPREQQSPAQPPPPPQQQQPPQQQVPPPPSS----------- 1428
            ..::||:|.||....:|                            :::||..|:           
 Frog  1296 KSLDEQLSAPKKDVKQP----------------------------EELPPMTSASEYAIRTAGKL 1332

  Fly  1429 -ADVDAQNAAAMMMAAGGANSTPGSVSSPNLPTDSSQVALPPPEPRYSYVDVNVSNFQLIGQQLV 1492
             |.|:.|.:.|:..|         :.::|  |..::.....||:|:|||.|::|.:...:...:.
 Frog  1333 WASVEKQESDAVFTA---------TATAP--PPSTTCTTTVPPQPQYSYHDIHVYSLAGLAPHIT 1386

  Fly  1493 LPPNTPFLHANPGIKHMVVNAVERTITDWLQPIVDRSIRIACATTEQIIRKDFALDADENRMRTA 1557
            |.|..|...|:|.:|..|..|:||.:.:.:.|:|||||:||..|.|||:|||||||::|:|||.|
 Frog  1387 LNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIA 1451

  Fly  1558 AHQMVRNLAAGMAMITGKDEIARAISQNLHKALLSGLN-GMPSMAE-IQAAAMQLASENVELVCA 1620
            ||.|:|||.|||||||.::.:..:|:.||..:..:.:. ..|...| ::.||.|||.:|.||.|.
 Frog  1452 AHHMMRNLTAGMAMITCREPLLMSIATNLKNSFATAMRAASPQQREMMEQAAAQLAQDNCELACC 1516

  Fly  1621 FIQKTSAEKAAAEIDRRLSTDFETRKIAREEGNRFVDAQILTYQQERLPEAVRIKVGAAPATLYA 1685
            |||||:.|||..|:|:|.:|:||.||.||:||.|:.|..:||||.||:||.:|:|||.......|
 Frog  1517 FIQKTAVEKAGPEMDKRPATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLA 1581

  Fly  1686 VYSEFARSIPGFQQMSDRDIALFVPKPTD-LSQP---NVFANDD-SMVYGELASKMEAFMNTAIG 1745
            ||.||||::|||...:|      :.:||. |:||   ..:|.|| :.:|.:..:::|..::....
 Frog  1582 VYEEFARNVPGFLPTND------LTQPTGFLAQPMKQQAWATDDVAQIYDKCITELEQHLHAIPP 1640

  Fly  1746 VPTLQIQASKMHMLLNALIATRRLRDQESAFNLLTRAVEGLTEGLVNMHENMEQMKMYQNIHLRI 1810
            ..::..|:..:..||.|:...|..||..:|..||.:|||||.:.......::  :..|:..||.:
 Frog  1641 ALSMNPQSQALRSLLEAVAVARNSRDAIAALGLLQKAVEGLLDATSGADADL--LLRYRECHLLV 1703

  Fly  1811 LGLLNN--SFGAPNTERAVTKCFFDIREEVRYNVEAARALITSHFVNLNQFDGMLRDCMDNGNNY 1873
            |..|.:  ::|:|...:.:|:|..:.|:|.:|||||...||.:|.||:.|:|..|...|:||.||
 Frog  1704 LKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNY 1768

  Fly  1874 VAISFGIALLERLIMDDRVINIVSDNEFMATVELLGRLTQH-RHRYPECIVNAIDTLWSGNFNSS 1937
            :|::|.:.|::.|::|:|.::.|::.||..|:|.|.|:..| |...||.:...:|.|.| ||::.
 Frog  1769 MAVAFAMQLVKILLVDERSVSHVTEAEFFHTIETLMRINAHSRGNAPEGLPQLMDVLRS-NFDAM 1832

  Fly  1938 SDYSPFNGNDRYLSGASHYIHSGMHHVRSCDTDDPPGLQEKTEFLLKDWVALYTQQNQQSTRDA- 2001
            .        :|...|.:..:|||:.  ::.:.||||||:||.|:||::||.||  .:..:.||: 
 Frog  1833 M--------ERAHGGPNFMMHSGIS--QASEYDDPPGLREKAEYLLREWVNLY--HSAAAGRDST 1885

  Fly  2002 RNFGAFVQKMNTYGILKTDDLITRFFRQATHICTDVVYRMFAE----PSLPINQAKNKIFQWIDA 2062
            :.|.|||.:|:..||||||||||||||..|.:|.::.||..||    |:......:.|.:..:||
 Frog  1886 KAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDA 1950

  Fly  2063 FVHLIAMLVRHSGEAGNPTTKINLLNKVLGIVLGTLIKDHEMRGVSFQQVGYHRFFMMLFMELCT 2127
            ||.|||:||:|||||.|..|||||||||||||:|.|::|||:|...|||:.|||.|:||.:||..
 Frog  1951 FVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHEVRQSEFQQLPYHRIFIMLLLELNA 2015

  Fly  2128 ADVILESLMHSIVSAFAYTYHLLNPSVAPGFCFAWLELISHRVFLGRILVQIPGQKGWPLYAQLL 2192
            .:.:||::....::||..|:|:|.|:.||||.:|||||||||:|:.|:|...|.|||||:|||||
 Frog  2016 PEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLL 2080

  Fly  2193 QDLFKYLAPFLRNTELGKPVQLLYKGTLRVLLVLLHDFPEFLCDYHFGFCDTIPPNCVQMRNIIL 2257
            .||||||||||||.||.||:|:||||||||||||||||||||||||:||||.|||||:|:||:||
 Frog  2081 IDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLIL 2145

  Fly  2258 SAFPRNMRLPDPFTPNLKVDMLSDSSNAPKVLSSYIMNIQPANFKKDLDSYLKARAPVTFLSELR 2322
            |||||||||||||||||||||||:.:.||::|::: ..:.|..||||||||||.|:|||||||||
 Frog  2146 SAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNF-TGVMPPQFKKDLDSYLKTRSPVTFLSELR 2209

  Fly  2323 GHLQVTSEPGTRYNMALMNALVMYVGTQAIALIRNKNFVPNTSNIAHSAHMDIFQNLAVDLDTEG 2387
            .:|||::|||.|||:.|:||||:||||||||.|.||...|:.|.|.|||||||||||||||||||
 Frog  2210 SNLQVSNEPGNRYNIQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEG 2274

  Fly  2388 RYLFLNAIANQLRYPNSHTHYFSCAVLHLFAEANSEAIQEQITRVLLERLIVNRPHPWGLLITFI 2452
            ||||||||||||||||||||||||.:|:||||||:||||||||||||||||||||||||||||||
 Frog  2275 RYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFI 2339

  Fly  2453 ELIKNPIYKFWDHDFVHCAPEITKLFESVARSCLAKSNVTQQLNMPVVDGEG 2504
            ||||||.:|||:|:||||||||.|||:|||:.|:.:....|     |::|.|
 Frog  2340 ELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQ-----VMEGTG 2386

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Not1NP_001286252.1 CNOT1_HEAT 582..737 CDD:293027 96/157 (61%)
CNOT1_TTP_bind 906..1079 CDD:293026 107/172 (62%)
CNOT1_CAF1_bind 1155..1373 CDD:293024 151/217 (70%)
DUF3819 1506..1649 CDD:289602 72/144 (50%)
Not1 2129..2478 CDD:281978 264/348 (76%)
cnot1NP_001090658.1 LXXLL 153..157 1/3 (33%)
LXXLL 181..185 1/3 (33%)
LXXLL 223..227 3/3 (100%)
CNOT1_HEAT 500..656 CDD:293027 96/157 (61%)
LXXLL 570..574 2/3 (67%)
CNOT1_TTP_bind 814..998 CDD:293026 109/185 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1012..1035 5/25 (20%)
CNOT1_CAF1_bind 1073..1298 CDD:293024 152/224 (68%)
Interaction with CCR4-NOT complex catalytic subunits. /evidence=ECO:0000250 1076..1617 287/585 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1300..1320 8/47 (17%)
DUF3819 1400..1545 CDD:289602 72/144 (50%)
LXXLL 1651..1655 0/3 (0%)
LXXLL 1954..1958 3/3 (100%)
Not1 2010..2365 CDD:281978 266/355 (75%)
LXXLL 2108..2112 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 571 1.000 Domainoid score I227
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H9453
Inparanoid 1 1.050 2045 1.000 Inparanoid score I49
OMA 1 1.010 - - QHG54022
OrthoDB 1 1.010 - - D42530at2759
OrthoFinder 1 1.000 - - FOG0003737
OrthoInspector 1 1.000 - - otm49442
Panther 1 1.100 - - LDO PTHR13162
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R833
SonicParanoid 1 1.000 - - X2594
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1212.110

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