DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and ARHGAP29

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_001315593.1	Gene:	ARHGAP29 / 9411	HGNCID:	30207	Length:	1261	Species:	Homo sapiens

Alignment Length:	909	Identity:	186/909 - (20%)
Similarity:	327/909 - (35%)	Gaps:	271/909 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   672 IRSILSSIIQSETIYVECLNKMMQYK-KAIHATLTTSQPVIREEEENTIFFKIDELYDLHTGFLS 735
            ::||::......::.::...:|:..| ||::.|      .:.||.:|.:|.::....:.......
Human    86 LKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFT------EVNEENKNDLFQEVFSSIETLAFTFG 144

  Fly   736 DLKT--IVSHEGGDVLIGEPFRRLAEMF--------------------DLYSAFLHNYKNAIETV 778
            ::.|  ::...|.|.|:..|..|..:.|                    :|.:..|.| .::||..
Human   145 NILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKN-TDSIELA 208

  Fly   779 KKCSANNPQF-KKIVSTI--VLNLQTEQSLTLEDLLHKPVARVQI------NALVFNDLLRETPN 834
            ...:....:: |.|||.:  .|||:.|.:..:..|.......:.|      .:|..|.||.:..:
Human   209 LSYAKTWSKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIES 273

  Fly   835 AHPDHQPLR--QAQKIIQMFLNQFN-VVNQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLF 896
            :|...|.:.  ||.|.:|..|.:.| :..||..|   :.|.:..:|    ::::....|:
Human   274 SHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEI---KELWKQEQN----KMLEAENALK----- 326

  Fly   897 NDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEADPAV-----ELKESSPANISQVKRNLRSV 956
                   |.|.|...|.|.             ||:|..::     |...||......:.:.|...
Human   327 -------KAKLLCMQRQDE-------------YEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKK 371

  Fly   957 R--DQLAMEVANSGSGAFR----SGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSS 1015
            |  ::.|::.....:..::    :.::.|..|.:.:.:::.....||.:........|:..|...
Human   372 RRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQ 436

  Fly  1016 DFERTQWIDSILSLKQKCNL--PG------------------------------------ANTI- 1041
            ..:.....||:.||.....|  ||                                    ||::
Human   437 HLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLE 501

  Fly  1042 ------------------NSLEVT--AFIVAMQKGMKTEM----GSYLMRNTNDESLLVGDLYMG 1082
                              ||.::|  :||.:...||.::.    ||...|:.:.||:..||.:..
Human   502 DVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRK 566

  Fly  1083 VHGLEG---LEQANDL--------------------YICVEVDSYGHYFRKATTKKICRSQTPLW 1124
            :.....   :..|:||                    ...:...:..|.|||..:...||
Human   567 LPRTPSSGTMSSADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCR------ 625

  Fly  1125 NESFMLELEGSQNVRILLYEAKE-RPLLKAKHILKLSLSWLTETTQPKSIKLTETLELGCSFRFI 1188
                  :.||     |::::..| ...|...|                 .|..|.|.:.|..:.:
Human   626 ------DCEG-----IVVFQGVECEECLLVCH-----------------RKCLENLVIICGHQKL 662

  Fly  1189 PGELFRGSTKPGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLK 1253
            ||::.        ||||:.:||.|:|...||||:..|..|:|.|.:...|.|||.|:.....||.
Human   663 PGKIH--------LFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLC 719

  Fly  1254 KAFESDAYEAEQLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNES------ 1312
            :|.|:..:..:  :.|...|.:..:||.:||:|||.....:||..|.|......:.||.
Human   720 QALENGMHLVD--ISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKN 782

  Fly  1313 -----------TRINELL----KVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFG 1362
                       ..||.:|    .:..:||.:|..|:..::.||.||.:...:|||:..||.::||
Human   783 SLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFG 847

  Fly  1363 PTLLRPGQTQVKQKDPLAASTV----------------------------DVMAQAGIL--YCF 1396
            |:|:||..|..    |:..|::                            |||...|::  .||
Human   848 PSLIRPRPTTA----PITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCF 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	43/215 (20%)
		PH_BCR_arthropod	851..1037	CDD:270174	33/199 (17%)
		C2	1079..1187	CDD:301316	19/131 (15%)
		RhoGAP	1203..1398	CDD:295372	70/245 (29%)
ARHGAP29	NP_001315593.1	BAR	220..436	CDD:299863	48/247 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..501		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	541..600		10/58 (17%)
		C1	612..657	CDD:197519	15/78 (19%)
		RhoGAP_PARG1	669..881	CDD:239874	64/217 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	981..1011
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1153
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1178..1238
		Interaction with PTPN13/PTPL1. /evidence=ECO:0000269\|PubMed:9305890	1258..1261
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940