DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and RGA1

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	NP_014770.1	Gene:	RGA1 / 854294	SGDID:	S000005653	Length:	1007	Species:	Saccharomyces cerevisiae

Alignment Length:	822	Identity:	176/822 - (21%)
Similarity:	298/822 - (36%)	Gaps:	268/822 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   772 KNAIETVK---KCSANNPQFKKIVSTIVLNLQTEQSLTLED-------LLHKPVARVQI------ 820
            :|:.|.|.   |..|..|.     :.:.||:.|:.:|:.::       ||:|...|...
Yeast   231 ENSTEHVNDDVKEEAEAPS-----ANMSLNVATDPTLSCKEPPSHSRNLLNKTPLRNSSGQYLAK 290

  Fly   821 ------NALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNR---------- 869
                  ..::.||.|.|:....|.:...|.|.:::...|:....||.:.|..||.
Yeast   291 SPSSYRQGIIVNDSLEESDQIDPPNNSSRNASELLTSVLHSPVSVNMKNPKGSNTDIFNTGEISQ 355

  Fly   870 ---NLRRMVRNSF----------IVELVDGHRKLRHLFLFNDVIACAKY-------------KAL 908
               :|.|.|.|:.          :||:|...|.:..|.......| .||             ::|
Yeast   356 MDPSLSRKVLNNIVEETNALQRPVVEVVKEDRSVPDLAGVQQEQA-EKYSYSNNSGKGRKISRSL 419

  Fly   909 GRDRIDYELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNLRSVRD---QLAMEVANSGSG 970
            .|...|.    .|.||..:..:: |..|:|   |||:....:|:...:||   ...::..||.|.
Yeast   420 SRRSKDL----MINLKSRATGKQ-DSNVKL---SPASKVTSRRSQDLMRDNDSHTGLDTPNSNST 476

  Fly   971 AF------RSGDKYRR------------KLADLESQL--VLATPNLVLR-LGNKANNKTITFFLS 1014
            :.      :....|:|            |...||.|.  ...:|:.:.. |.:.|....::.:
Yeast   477 SLDILVNNQKSLNYKRFTDNGTLRVTSGKETALEEQKNHSFKSPSPIDHLLQSPATPSNVSMY-- 539

  Fly  1015 SDFERTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDL 1079
                ||..:||.|:..::.....:|...|      |.:.||..||:     :.|:::.......|
Yeast   540 ----RTPPLDSSLTFDRRNGSSYSNQNYS------IPSWQKTPKTQ-----LENSDNFEEQKETL 589

  Fly  1080 YMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILL-- 1142
            |      |..|..||..:..|:.:..||.::.   ||...:.....|..|.|:...::::..|
Yeast   590 Y------ENSESRNDPSLDKEIVTAEHYLKQL---KINLKELESQREELMKEITEMKSMKEALRR 645

  Fly  1143 ----YEAKER-------------PLLK---------AKHILKLSLSWLTETTQPKSIKL------ 1175
                |.:::.             |::.         .||:...| |....:.:||..|.
Yeast   646 HIESYNSEKNKLYLDSNELSNNPPMINEISLGESPPVKHVATAS-SVARSSVKPKFWKFFSSAKP 709

  Fly  1176 -TETLELGCS------------------------------------------FRFIP--GELFRG 1195
             ||....|.|                                          .|.:|  .:...|
Yeast   710 QTEQSIQGVSTNNTNSIVKSAPVLLSAPSSGSNSGRLEISPPVLQNPNEFSDVRLVPIENDANMG 774

  Fly  1196 STKPGA-------LFGAKMSQVLKREKRDIPFIIGACIR--EVERRGMLEVGCYRVSGSASDLAK 1251
            .:|.|.       |:|:.:......|..:||.|:..||.  |.:...|...|.||.|||...:.:
Yeast   775 QSKDGEEYLDGSNLYGSSLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVIEE 839

  Fly  1252 LKKAFESDAYEAEQ------LLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNN 1310
            ::|.|  .|::.:|      :|.|.|::.|||:||.:||:||..:||.|:|....
Yeast   840 IEKQF--SAWKVQQNTETPNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLM---------- 892

  Fly  1311 ESTRINELLKVFEELP----------------QANKASITSILDHLIRVH-----------EKET 1348
               |:.:..|:.|.||                .::|:::.:||:.|.|.|           ||.|
Yeast   893 ---RLVKSKKMMENLPFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVT 954

  Fly  1349 D----NKMSLHNLAMVFGPTLLR--PGQTQV---KQKDPLAA 1381
            .    |:|:|:|||:||.|.|:|  .|:..:   |:::.:.|
Yeast   955 RYSHWNRMTLYNLALVFAPGLIRDFSGEKDIIDMKERNYIVA 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	22/106 (21%)
		PH_BCR_arthropod	851..1037	CDD:270174	50/245 (20%)
		C2	1079..1187	CDD:301316	28/184 (15%)
		RhoGAP	1203..1398	CDD:295372	63/223 (28%)
RGA1	NP_014770.1	LIM1_Rga	13..67	CDD:188780
		LIM2_Rga	70..123	CDD:188781
		Smc	<569..>673	CDD:224117	22/117 (19%)
		RhoGAP	803..1002	CDD:214618	61/209 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940