DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP1A and RGD1

DIOPT Version :9

Sequence 1:NP_001284725.1 Gene:RhoGAP1A / 5740235 FlyBaseID:FBgn0025836 Length:1404 Species:Drosophila melanogaster
Sequence 2:NP_009819.1 Gene:RGD1 / 852563 SGDID:S000000464 Length:666 Species:Saccharomyces cerevisiae


Alignment Length:725 Identity:156/725 - (21%)
Similarity:269/725 - (37%) Gaps:209/725 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   742 SHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKKIV-STIVLNL---QTE 802
            ||:||.       ..||.:|                      :.|:.||:: |.:.:|.   :.:
Yeast    18 SHDGGT-------DDLAHLF----------------------STPEIKKVLNSDVAINALLSRLK 53

  Fly   803 QS-LTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIE 866
            || ||.|:               |...:|:......:|     .|::.:.:.:.||:..     .
Yeast    54 QSLLTCEE---------------FMKFIRKKYAFEEEH-----VQELSKQYKHFFNIQG-----S 93

  Fly   867 SNRNLRRM-------------VRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYELK 918
            :|.:|::|             |:.|:|..|...:.::..|.|  .:....|.......|::    
Yeast    94 TNSSLKKMIHEVLGFDGKMAQVKQSYITALQKMYSEISSLLL--TMTKLRKSVKENSKRLE---- 152

  Fly   919 WFIPLKDVSIYEEADPAVELKESSPANISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLA 983
                 ||||   :|..:.|..:|...::.|....|| :.|....::...||          :...
Yeast   153 -----KDVS---DAIHSAEKAQSRYNSLCQDWDKLR-MTDPTKTKLTLRGS----------KTTK 198

  Fly   984 DLESQLVLATPNLVLRLGNKA--NNKTITFFLSSDFERTQW--------IDSILSLK-QKCNLPG 1037
            :.|.:|:....|..|....|.  :|.....|::.:..|...        ||:.:::: ||..:..
Yeast   199 EQEEELLRKIDNADLEYKQKVDHSNSLRNTFITKERPRIVQELKDLILEIDTAMTIQLQKYTIWT 263

  Fly  1038 ANTINSLEVTAFIVAMQKGMKTEMGS-------YLMRN----TNDESLLVGDLYMGV-------- 1083
            .|.:.:..||...:...|.||:..||       |...|    |...|||:....:.|        
Yeast   264 ENLVLNTGVTISPLDSTKSMKSFAGSVSNERDLYSFLNKYNQTGKHSLLINKNLIPVSYKKHPSM 328

  Fly  1084 -HGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRIL------ 1141
             ||     |.|.......||.    .|.:..|::..:.    |||..  |..|.|...:      
Yeast   329 NHG-----QKNKSPPKFAVDP----SRNSIPKRMISTH----NESPF--LSSSSNTAAVPNANLN 378

  Fly  1142 -----LYEAKERPLLKAKHI---------LKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGEL 1192
                 |...|:.|...|..|         :..|.|.:|..|   :..:|:||:.|.:...||.||
Yeast   379 SATPSLNTNKQLPPTMASSISSTSNAAGAMSPSSSIVTSDT---TSSITKTLDPGNNSPQIPEEL 440

  Fly  1193 F--------------RGSTKPGA-----LFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVG 1238
            .              ..:..||.     .||..:..:::.|:..:|.|:..||..:::.|:.:.|
Yeast   441 INSLDSDRPISHIQTNNNMPPGVQKNFKTFGVPLESLIEFEQDMVPAIVRQCIYVIDKFGLDQEG 505

  Fly  1239 CYRVSGSASDLAKLKKAFESDAYEAEQLL-----REVDIHSVTGILKTFLRELPEALFTDQLYPR 1298
            .||.|.:..|::|||:..:.|......:|     .:.||:.|..:||||...||     |.:.|:
Yeast   506 IYRKSANVLDVSKLKEEIDKDPANISMILPSKPHSDSDIYLVGSLLKTFFASLP-----DSVLPK 565

  Fly  1299 FFDTFSAFSN--------NNESTRINELLKVFEELPQANKASITSILDHLIRVHEKETDNKMSLH 1355
                  |.|:        .:.:||.|.:..:...||.|...::.:::.||.||...|..|:|:|.
Yeast   566 ------ALSSEIKVCLQIEDPTTRKNFMHGLIYNLPDAQYWTLRALVFHLKRVLAHEAQNRMNLR 624

  Fly  1356 NLAMVFGPTL 1365
            .|.:::|||:
Yeast   625 ALCIIWGPTI 634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP1ANP_001284725.1 RhoGEF 675..857 CDD:214619 21/119 (18%)
PH_BCR_arthropod 851..1037 CDD:270174 38/209 (18%)
C2 1079..1187 CDD:301316 28/136 (21%)
RhoGAP 1203..1398 CDD:295372 49/176 (28%)
RGD1NP_009819.1 F-BAR_Rgd1 39..268 CDD:153336 50/278 (18%)
RhoGAP_fRGD1 470..663 CDD:239863 49/176 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2255
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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