Protein Alignment RhoGAP1A and RGA2

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: NP_010667.1
• Gene: RGA2 / 851985
• SGDID: S000002787
• Length: 1009
• Species: Saccharomyces cerevisiae
• Alignment Length: 1163
• Identity: 232/1163 - (19%)
• Similarity: 403/1163 - (34%)
• Gaps: 326/1163 - (28%)

  Fly   339 PSSSSGSLCIDSLGNSLERNIKPSDILRQKSSDNLDSKYSAKRKTTPELSKFVNVNNPELMEELG 403
            |.:...|||:     ...::|..|.:...:|     .|:..:..|..:..|.:|.::..|:.::|
Yeast     5 PINDQSSLCV-----RCNKSIASSQVYELES-----KKWHDQCFTCYKCDKKLNADSDFLVLDIG 59

  Fly   404 R--------KMVSKADSLEQT-----RRNDSSPSGCGSLGRTSSTPGRSLTPGRTGVGASPTG-- 453
            .        |..:..|.::.|     ..|::..|.|....|.|:.. ::|...:|..|.....
Yeast    60 TLICYDCSDKCTNCGDKIDDTAIILPSSNEAYCSNCFRCCRCSNRI-KNLKYAKTKRGLCCMDCH 123

  Fly   454 -SLSKTGKLAMADSSSTSS-------LERRSCLQAVD-------ADIGTESRESGANQRSVGSKE 503
             .|.:..:|.:.:.:..||       |..||..:.:.       :|:.|.:.....|..|....:
Yeast   124 EKLLRKKQLLLENQTKNSSKEDFPIKLPERSVKRPLSPTRINGKSDVSTNNTAISKNLVSSNEDQ 188

  Fly   504 SLTSQGISEVQIKSYESVSSL-------SSESAKAVASQQSAAAGGALAECEPYYDSVPL----- 556
            .||.|    |.:......|||       :|:..:..:|.....:...:......:||..:
Yeast   189 QLTPQ----VLVSQERDESSLNDNNDNDNSKDREETSSHARTVSIDDILNSTLEHDSNSIEEQSL 249

  Fly   557 -DNGD-----GE---YVFIKPGRTGSSSSRDDLSTPGSSILPLPNVADPESPGRTSNYVNIDFFL 612
             ||.|     ||   |..:||.|    ::||.:.           |.||..|...|| .|..|.:
Yeast   250 VDNEDYINKMGEDVTYRLLKPQR----ANRDSIV-----------VKDPRIPNSNSN-ANRFFSI 298

  Fly   613 QQGIETRSSSLDSDGEYEGPPILRT--ISHDDQTTTQTTPGAIRKN--------LVSAILVCGNA 667
            ....||.....|:.   |...|:.|  .|.|..|:...:|.|::.|        |...:     :
Yeast   299 YDKEETDKDDTDNK---ENEIIVNTPRNSTDKITSPLNSPMAVQMNEEVEPPHGLALTL-----S 355

  Fly   668 RGAKIRSILSSIIQSETIYVECLNKMMQYKKAIHATLT------TSQPVIREEEENTIFFKIDEL 726
            ...|..:..|..||:.|      :|.|.:...|..|.|      ||...:|
Yeast   356 EATKENNKSSQGIQTST------SKSMNHVSPITRTDTVEMKTSTSSSTLR-------------- 400

  Fly   727 YDLHTGFLSDLKTIVSHEGGDVLI------GEPFRRLAEMFDLYSA-FLHNYKNAIETVKKCSAN 784
                   |||..:....:..|.|:      ..|.::|:..|.|.|. |:||.|:  :|.:.....
Yeast   401 -------LSDNGSFSRPQTADNLLPHKKVAPSPNKKLSRSFSLKSKNFVHNLKS--KTSEMLDPK 456

  Fly   785 NPQFKKIVSTIVLNLQTEQ---------SLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQ 840
            :|..    ||.:....|..         ::........||:|.|.::.::|.|        |.|.
Yeast   457 HPHH----STSIQESDTHSGWGVSSTHTNIRKSKAKKNPVSRGQSDSTIYNTL--------PQHG 509

  Fly   841 PLRQAQ---KIIQMFLNQFNVVNQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIAC 902
            .....:   |..|..|...:.........:||.:     |........||    |:.:|...
Yeast   510 NFTVPEFNHKKAQSSLGSISKKQNSNDTATNRRI-----NGSFTSSSSGH----HIAMFRTP--- 562

  Fly   903 AKYKALGRDRIDYELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNLRSVRDQLAMEV-AN 966
                               ||:...:::....:.|......::: |..|:..::.:..:.:| |.
Yeast   563 -------------------PLESGPLFKRPSLSSESAHHRSSSL-QTSRSTNALLEDDSTKVDAT 607

  Fly   967 SGSGAFRSGDKY------------RRKLADLESQLVLATPNLVL---RLGNKANNKTITFFLSSD 1016
            ..|......|.|            .|:|...:.:|:....||.|   ||.|..:|      |:.:
Yeast   608 DESATSLEKDFYFTELTLRKLKLDVRELEGTKKKLLQDVENLRLAKERLLNDVDN------LTRE 666

  Fly  1017 FERTQWIDSILSLKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGS-----YLMRNTNDESLLV 1076
            .:: |...|..||:||.|:..:.|:.|....    :.:||..:....     .:..:..|..  |
Yeast   667 KDK-QSASSRESLEQKENIATSITVKSPSSN----SDRKGSISNASPKPRFWKIFSSAKDHQ--V 724

  Fly  1077 GDLYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRIL 1141
            |||                                      .||....|.|    ..|:.|:
Yeast   725 GDL--------------------------------------ESQQRSPNSS----SGGTTNI--- 744

  Fly  1142 LYEAKERPLLKAKHILKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGELFRGSTKPGA-LFGA 1205
               |::                  |.:.||.|::.:.|.........|.......|..|: |:|:
Yeast   745 ---AQK------------------EISSPKLIRVHDELPSPGKVPLSPSPKRLDYTPDGSHLYGS 788

  Fly  1206 KMSQVLKREKRDIPFIIGACIREVERR--GMLEVGCYRVSGSASDLAKLKKAF-ESDAYEAEQL- 1266
            .:......||..:|.||..||..:|:.  |:...|.||.|||.:.:.:::..| ::::..::.|
Yeast   789 SLQARCAYEKSTVPIIIRCCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEFAQNNSLHSDTLS 853

  Fly  1267 -----LREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTF-------------SAFSNNNEST 1313
                 |...|||:|..:||.:||:||:.:.:..:|....|..             ..|.::.:..
Yeast   854 PKLNALLNQDIHAVASVLKRYLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLDSPQKV 918

  Fly  1314 RINE-----LLKVFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLL 1366
            .|.|     ||::|:.||..::..:..:..|:.:|......|.|:||||::||.|:|:
Yeast   919 TIYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRCSERNLMNLHNLSLVFAPSLI 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	42/206 (20%)
		PH_BCR_arthropod	851..1037	CDD:270174	36/201 (18%)
		C2	1079..1187	CDD:301316	13/107 (12%)
		RhoGAP	1203..1398	CDD:295372	51/191 (27%)
RGA2	NP_010667.1	LIM1_Rga	13..67	CDD:188780	10/63 (16%)
		LIM2_Rga	70..123	CDD:188781	10/53 (19%)
		RhoGAP	815..1002	CDD:214618	42/162 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030