DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP1A and si:dkey-33c9.6

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	XP_021327566.1	Gene:	si:dkey-33c9.6 / 795086	ZFINID:	ZDB-GENE-130530-592	Length:	829	Species:	Danio rerio

Alignment Length:	857	Identity:	243/857 - (28%)
Similarity:	423/857 - (49%)	Gaps:	121/857 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   608 IDFFLQQGIE--TRSSSLDSDGEYEGPPILRTI--------SHDDQTTTQTTPGA---------I 653
            :::....||.  |....:|||       :|..:        |||...|....|..         :
Zfish     8 VEYLKAYGISPVTEDEMMDSD-------LLHDVFPEESDWGSHDSMQTEPCLPSTPTSDNPDDLL 65

  Fly   654 RKNLVSAILVCGNARGAKIRSILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENT 718
            :|.:|                :|..::.||.||:..|..::...||:.|:..|||||:..|:..|
Zfish    66 QKRMV----------------VLKRVLLSEEIYLMELETLLTPMKALKASAGTSQPVLSTEQVQT 114

  Fly   719 IFFKIDELYDLHTGFLSDLKT----------------------IVSHEGGD--VLIGEPFRRLAE 759
            :|:::.||.|||..|.:.|:|                      ::.|..|:  :.:|:.|.:...
Zfish   115 VFYQVPELRDLHRQFYTSLQTKLHPDNVMDQGSQQSLGRDEGPVMQHYQGEHHLSVGDVFLKFVN 179

  Fly   760 MFDLYSAFLHNYKNAIETVKKCSANNPQFKKIVSTIVL-----NLQTEQSLTLEDLLHKPVARVQ 819
            ...:|..|:.||:||::.|:||..::.:|:.:..:::.     |::|:  .|.|.||:||:.||.
Zfish   180 QLGVYRGFIDNYENAVKIVQKCMLSDQRFRILAESMMSSKSSDNVKTK--YTFEALLYKPLDRVM 242

  Fly   820 INALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQ-RLPIESNRNLRR-MVRNSFIVE 882
            ...||.:||.:.||..|||...|::|.::...|::..|..:| :.|:...|..|| ::|:.|:|:
Zfish   243 KTTLVLHDLWKHTPPEHPDSITLQEALRLSSSFMSGVNERSQCKQPVMLCRGERRQLMRDGFVVD 307

  Fly   883 LVDGHRKLRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEAD--PAVELKESSPAN 945
            :.:....||||||:.|::.|||....|| :..|...|::||..:.::..|:  |:.|.:    ..
Zfish   308 VCESGHNLRHLFLYTDMLLCAKLTNAGR-QAQYRFCWYLPLVGLKLHWTAEHLPSSEYQ----MK 367

  Fly   946 ISQVKRNLRSVRDQLAMEVANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTIT 1010
            ||:.:..:..::..|...:..|.....|:.|:.||||.:.|..|:..||:..|.| :..:.|:.|
Zfish   368 ISKTRVKMYQLKQALLQHMKGSKGSVSRAVDRLRRKLEECEIWLLTNTPSFTLDL-HSTSGKSHT 431

  Fly  1011 FFLSSDFERTQWIDSILSLKQKCNLPGANTINS-----LEVTAFIVAMQKGMKTEMGSYLMRNTN 1070
            ..|.|.::..:|.|:|   :::|    .|.|.:     |.||:..:.::   .|:........:|
Zfish   432 VRLLSLYDLNEWKDAI---EKQC----GNCIETVPPDLLSVTSSCIKLR---MTQQPPLHCVQSN 486

  Fly  1071 DESLLVGDLYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGS 1135
            :.:.:.|.||:.|....||:..:..|:|||||.:..|.|:..|.......||.|:|..:..::|:
Zfish   487 ESAQICGSLYVMVQSACGLQHPSSAYVCVEVDGFECYDRRKQTSLSAFCVTPQWDEELVFIVDGA 551

  Fly  1136 QN---VRILLYEAKERPLLKAKHILKLSLSWLTETTQPKSIKLTETL---ELGCSFRFIPGELFR 1194
            :.   |.:..||...:..:..:.:|.|.    .:....|..|:|.:|   ::..|.:::|..|..
Zfish   552 KQLFLVFVCQYENDTQNDIVGRTVLNLD----PDNMFKKWKKVTCSLGHVDVTLSLKYVPHPLEP 612

  Fly  1195 GSTKP---GALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAF 1256
            .||.|   ..:|...:.||..:|...:|.|:.:|:.||||||:.|.|.||:||:::::..||.||
Zfish   613 PSTTPILQEPVFCVPIGQVAMQESVLVPHIVRSCVEEVERRGLKEEGIYRISGASTEIQALKYAF 677

  Fly  1257 ESDAYEAEQLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKV 1321
            .::..||...||.||:::|:|.||.:.||||..|...:   .|.:...|....:...|.:.||.:
Zfish   678 NTNYREAVSKLRSVDVNAVSGTLKLYFRELPLPLIPCE---HFSELSDALDIADPFVRADSLLSL 739

  Fly  1322 FEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVKQKDPLAASTVDV 1386
            .:.||..|:.::..:|.||.||.|::.:|||||.|||.||||:||||..::|.     .:..|:|
Zfish   740 LQSLPDVNRNTLLFLLHHLRRVAERKEENKMSLSNLATVFGPSLLRPPVSRVD-----ISQEVEV 799

  Fly  1387 MAQAGILYCFLQ 1398
            ..|  :::.:||
Zfish   800 QVQ--VIFLYLQ 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	61/210 (29%)
		PH_BCR_arthropod	851..1037	CDD:270174	53/189 (28%)
		C2	1079..1187	CDD:301316	29/113 (26%)
		RhoGAP	1203..1398	CDD:295372	72/194 (37%)
si:dkey-33c9.6	XP_021327566.1	RhoGEF	71..281	CDD:214619	61/211 (29%)
		PH-like	297..453	CDD:327399	47/168 (28%)
		C2	495..605	CDD:326325	29/113 (26%)
		RhoGAP	624..812	CDD:295372	74/196 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595583
Domainoid	1	1.000	146	1.000	Domainoid score	I4480
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24962
orthoMCL	1	0.900	-	-		OOG6_104879
Panther	1	1.100	-	-	O	PTHR23182
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850