Protein Alignment RhoGAP1A and abr

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: XP_012812699.1
• Gene: abr / 779766
• XenbaseID: XB-GENE-5797083
• Length: 1019
• Species: Xenopus tropicalis
• Alignment Length: 1168
• Identity: 333/1168 - (28%)
• Similarity: 531/1168 - (45%)
• Gaps: 275/1168 - (23%)

  Fly   270 PPSTFSRYSEATAPPLSPSLTSYAAHVEAKKKMPPRPPPKNIRRVEPPTIPSQQLSSSPKRETYM 334
            ||..|.|                   |.:.|..||.||.:     .||.:|.:.....
 Frog    68 PPKPFPR-------------------VRSNKPPPPVPPQR-----APPPLPDRDYEDE------- 101

  Fly   335 INTMPSSSSGSLCIDSLGNSLERNIKPSDILRQKSSDNLDSKYSAKRKTTPELSKFVNVNNPELM 399
                 ..|:....:|:|       :.|:..||......                          .
 Frog   102 -----RGSTERFVLDNL-------LSPAGELRPGGGGE--------------------------E 128

  Fly   400 EELGRKMVSKADSLEQTRRNDSSPSGCGSLGRTSSTPGRSLTPGRTGVGASPTGSLSKTGKLAMA 464
            |..||:..|:|:     :|.|           ..:.||..          ||..|..:.|    :
 Frog   129 ETAGRERGSRAE-----KRRD-----------LLTVPGWD----------SPRHSSPERG----S 163

  Fly   465 DSSSTSSLERRSCLQAVDADIGTESRESGANQRSVGSKESLTSQGISEVQIKSYESVSSLSSESA 529
            |...:|.||..   :::|.:.||:..::..|:....|:|.
 Frog   164 DDYLSSDLEED---RSIDFNYGTDGYDAEGNEEHKSSREG------------------------- 200

  Fly   530 KAVASQQSAAAGGALAECEPYYDSVPLDNGDGEYVFIKPGRTG-SSSSRDDLS-TPGSSILPLPN 592
                           :|..||.|..|.         :.|..:. |..|.|.:| ||...:||
 Frog   201 ---------------SETMPYIDESPT---------MSPQLSARSQDSVDGVSPTPTEVLLP--- 238

  Fly   593 VADPESPGRTSNYVNIDFFLQQGIETRSSSLDSDGEYEGPPILRTISHDDQTTTQTTPGAIRKNL 657
                                             .||                 :::..|.:.:.|
 Frog   239 ---------------------------------GGE-----------------SESDKGLLMRKL 253

  Fly   658 VSAILVCGNARGAKIRSILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFK 722
            |                 ||.::.||.||:..|..::...|.:.||.:|||||:..::.|.||:|
 Frog   254 V-----------------LSGVLASEEIYINQLEALLLPMKPLKATASTSQPVLTLQQINDIFYK 301

  Fly   723 IDELYDLHTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQ 787
            |:::|.:|..|...|..||........:|..|::||....:|.||:.|||.|:||.:|||..|.|
 Frog   302 IEDIYQMHKDFYDKLCPIVLQFDNKTTVGHLFQKLASQLGVYKAFVDNYKFALETAEKCSQCNVQ 366

  Fly   788 FKKIVSTIVL-----NLQTEQSLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQK 847
            |.||...:.:     :.:..||:|:|.||:||:.||..:.||.:|||:.||..|||:..|:.|.:
 Frog   367 FFKISEDLKVKGPKDSKEQPQSVTMEALLYKPIDRVTRSTLVLHDLLKHTPTDHPDYPLLQDALR 431

  Fly   848 IIQMFLNQFN--VVNQRLPIESNR-NLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYK--A 907
            |.|.||:..|  :..:|..:.:.: ..|::|::.|:|||.:..|||||||||.|::.|||.|  .
 Frog   432 ISQNFLSSINEDIDPRRTAVTTPKGEPRQLVKDGFLVELSENSRKLRHLFLFTDLLLCAKLKKTT 496

  Fly   908 LGRDRIDYELKWFIPLKDVSIY---EEADPAVELKESSPANISQVKRNLRSVRDQLAMEVANSGS 969
            :|:.: .|:.||:|||.|: ::   ||::|..:|..:....|.::|..:..::.::..| ..|..
 Frog   497 VGKHQ-QYDCKWYIPLADL-VFPSPEESEPIPQLHATPDHEIEEMKAKISVLKSEIQKE-RKSNK 558

  Fly   970 GAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKCN 1034
            |:.|:.::.::|:.:.||.|:|.:|.:..|:.|| |.|:..|.||||:||::|.::|..| ||.:
 Frog   559 GSSRTIERLKKKMFEYESWLLLYSPTIPFRIHNK-NGKSYFFLLSSDYERSEWREAIQKL-QKKD 621

  Fly  1035 LPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESL-LVGDLYMGVHGLEGLEQANDLYIC 1098
            |. |..::..|:.....:..|.........:....:|||. |.|.|::.|...:|...:::||..
 Frog   622 LQ-ALALSPFELQVLTASCFKLRTVHNVPIISHKDDDESPGLYGFLHVIVKSAKGFSHSSNLYCT 685

  Fly  1099 VEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEA--------KER----PLL 1151
            :||||:|::..||.|:....:..|.|||.|.:||||||.:|||.||.        |:.    ..:
 Frog   686 LEVDSFGYFVSKAKTRVFRDTTEPEWNEEFEIELEGSQCLRILCYEKCYDKSKLNKDNNEIVDKI 750

  Fly  1152 KAKHILKL------SLSWLTETTQPKSIKLTETLELG---CSFRFIPGELFRGSTKPGALFGAKM 1207
            ..|..::|      |.:|..:..:...||:..:::..   .|.:..|      |.|...:||.|:
 Frog   751 MGKGQIQLDPQVVQSKNWHDDVIEMNGIKVEFSMKFSSRDMSLKRTP------SKKQTGVFGVKI 809

  Fly  1208 SQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLLREVDI 1272
            |.|.|||:..:|:|:..||.|||:||:.|||.||:||.|:|:..||.:|::::.:...:|.::||
 Frog   810 SVVTKRERSKVPYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKASFDANSKDILMMLSDMDI 874

  Fly  1273 HSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASITSIL 1337
            :::.|.||.:.|||||.|.||:||..|.:   ..:.::.:.:.|.::.:...||..|..:...:|
 Frog   875 NAIAGTLKLYFRELPEPLLTDRLYLAFME---GIALSDPAAKENCMMHLLRSLPDPNLMTFLFLL 936

  Fly  1338 DHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVKQKDPLAAS--TVDVMAQAGILYCFLQ 1398
            .||.||.|||..|||||||||.|||||||||.:.:.|....||:.  :.|||||..:|..:||
 Frog   937 QHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKGHMNLASDIWSHDVMAQVQVLLYYLQ 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	73/186 (39%)
		PH_BCR_arthropod	851..1037	CDD:270174	66/193 (34%)
		C2	1079..1187	CDD:301316	37/128 (29%)
		RhoGAP	1203..1398	CDD:295372	85/196 (43%)
abr	XP_012812699.1	Bcr-Abl_Oligo	3..65	CDD:312543
		RhoGEF	254..442	CDD:214619	74/204 (36%)
		PH_ABR	436..620	CDD:270172	64/188 (34%)
		C2_ABR	666..786	CDD:176068	36/119 (30%)
		RhoGAP_Bcr	805..1000	CDD:239852	87/198 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I4645
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11081
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1533
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	1	1.000	-	-		FOG0002220
OrthoInspector	1	1.000	-	-		otm48222
Panther	1	1.100	-	-	LDO	PTHR23182
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	1	1.000	-	-		X2211
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100