DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP1A and arhgap27

DIOPT Version :9

Sequence 1:	NP_001284725.1	Gene:	RhoGAP1A / 5740235	FlyBaseID:	FBgn0025836	Length:	1404	Species:	Drosophila melanogaster
Sequence 2:	XP_002933206.3	Gene:	arhgap27 / 779583	XenbaseID:	XB-GENE-982958	Length:	1024	Species:	Xenopus tropicalis

Alignment Length:	1209	Identity:	237/1209 - (19%)
Similarity:	419/1209 - (34%)	Gaps:	337/1209 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 LRKST------SQYVTVIQVKEAKDKESADGTTSSSGIGEPQQQPTPPSTFSRYSEATAPPLSPS 288
            |.|:|      ::||.|:.:...:    .:|........|..|...|.:.:|.......|.:|.:
Frog    51 LDKTTTPFYIPAKYVKVLPLASKR----FNGYQPYKDPSEDVQVAVPSNEYSYKFLPPCPQVSAN 111

  Fly   289 LTSYAAHVEAKKKMPPRPPPKNIRRVEPPTIPSQQLSSSPKRETYMI-----------NTMPSSS 342
            :|               |||.:|:    |.|....::|..:..:..:           ||:|..|
Frog   112 VT---------------PPPLDIQ----PAITDNAITSRNECASKALAPVKVPCINTSNTLPKVS 157

  Fly   343 SGSLCIDSLGNSLERNIKPSDILRQKSSDNLDSKYSAKRKTTPELSKFVNVNNPELMEELGRKMV 407
            ...|.        ..|..||..:.:.:|:|:      :.|..|:    :::|
Frog   158 MPKLA--------ATNTLPSATVPRVNSNNV------QPKVVPQ----IHIN------------- 191

  Fly   408 SKADSLEQTRRNDSS---PSGCGSLGRTSSTPGRSLTPGRTGVGASPTGSLSKTGKLAMADSSST 469
               |.|..|.:..||   |:.......|...|.....|....:....:|          .|||.|
Frog   192 ---DVLTSTPQIHSSNILPTNDKQNSATQPEPSTQFLPSDLPMVCGASG----------LDSSHT 243

  Fly   470 SSLERRSCLQAVDADIGTESRESGANQRSVGSKESLTSQGISEVQ--IKSYESVSSLSSESAKAV 532
            ...|     |..|:......|....:::.|...:.::...:::.|  |.:..|..:|..|.:...
Frog   244 YPKE-----QPEDSRTHAPMRTFHNSKKVVDPTKRISFLCLTDAQPNILTTPSSGNLKPEPSTTY 303

  Fly   533 ASQQSAAAGGALAECEPYYDSVPLDNGDGEYVFIKPGRTGSSSSRDDLSTPGSSILPLPNVADPE 597
            ..||......:...|.|            |.|.|....|..|:....|..|         :.:.|
Frog   304 HQQQPHKINDSSGLCCP------------EQVVIVTSNTAGSNGISPLVQP---------IKEEE 347

  Fly   598 SPGRTSNYVNIDFFLQQGIETRSSSLDSDGEYEGPPILRTISHDD-QTTTQTTPGAI-RKNLVSA 660
            ..|..  |.|:..|.::....|:|||....         |.:.|| :|.|.|..|.: ..|.|:.
Frog   348 DCGPL--YENLKPFQKETPRERASSLQHSS---------TSTLDDWETHTDTGSGQLFYYNSVTG 401

  Fly   661 ILVCGNARGAKIRSILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQPVIREEEENTIFFKIDE 725
            :....           |...|.|.            .:....:|.:..|:..:.:....|.:..:
Frog   402 VTTWD-----------SPFDQPED------------PEPSPTSLNSLSPLAEDSQWEKHFDEATK 443

  Fly   726 LYDLHTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKK 790
            .|..:....           |:.....|...::  |..::..:.:|.:.........|:.|.:
Frog   444 KYYFYNSVT-----------GETSWDPPVEEMS--FQEFTPMVSSYISVDRRPPTPEADYPDY-- 493

  Fly   791 IVSTIVLNLQTEQSLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQ 855
                           |||:....|.|          |..::.|..: :..||.::
Frog   494 ---------------TLEEGESYPDA----------DYHQDPPGLY-EQIPLHKS---------- 522

  Fly   856 FNVVNQRLPIES--------NRNLRRMVRNSFIVEL-VDGHRKLRHLFLFNDVIACAKYKALGRD 911
                    |::.        |::.::...|::..|: |....:....|.:..
Frog   523 --------PVDPNSGWFCQVNKDGKKFYSNNYNSEIWVQSEDQSGKTFFYTQ------------- 566

  Fly   912 RIDYEL-KWFIP-LKDVSIYEEADP---AVELKESSPANISQVKRNLRSVRDQLAMEVANSGSGA 971
              |..| :|.:| :...|::...|.   ..:|:::.||..:      |...:.....:..:||..
Frog   567 --DGSLSQWSLPRIGPASLHRPNDDNNVFTKLQDNYPAITA------RKDTEDFGHRLRRAGSED 623

  Fly   972 FRS--GDKYRRKLADLESQLVLATPNLVLRLGNKA----NNKTITFFLSSDFERTQWIDS----- 1025
            |.:  ||.:..:...||...||          :||    |.|.:         |..|..|
Frog   624 FLNVGGDHHPHQTKSLEKAGVL----------HKAKISDNGKKL---------RKSWSSSWTVLE 669

  Fly  1026 --ILS-LKQKCNLPGANTINS-LEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDLYMGVHGL 1086
              ||: .:...||...::.:| |....:.|.::       |:.|:..|.|:|       ...|.|
Frog   670 GGILTFFRDGKNLSSNSSRHSQLSTPEYTVRLE-------GASLVWATKDKS-------SKKHVL 720

  Fly  1087 EGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAKERPLL 1151
            | |:..|.....:..||              .:.|..|:||....:  ::|:|:   .|...|..
Frog   721 E-LKTRNGSEYLIHHDS--------------ETITADWHESIKNSI--ARNIRV---SADHTPED 765

  Fly  1152 KAKHILKLSLSWLTETTQPKSIKLTETLELGC---SFRFIPGEL--------------FRGSTKP 1199
            :.:...:..   .||....|..|...::..|.   |.|.:..:|              .||..|.
Frog   766 EPEPFQEFG---STEKLGTKDEKKNSSMGSGSNSDSDRKVRAKLKKFLQRRPTIQSLRDRGYIKE 827

  Fly  1200 GALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAE 1264
             .:||..:.|:.:|||:::|..:...|:.||:||:...|.|||||:.:.:.||:...:.:.....
Frog   828 -QVFGCPLQQLCEREKQNVPDFVRKAIQAVEKRGLDIDGLYRVSGNLATIQKLRHKVDQEENTNL 891

  Fly  1265 QLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQAN 1329
            :..|..|:|.:||.||.|.|||||.||....:..|.:|...   |:.:.:..:..::.:.||..|
Frog   892 EDGRWEDVHVITGALKLFFRELPEPLFPFSHFDMFIETIKL---NDPALKKKQFKELIQSLPPPN 953

  Fly  1330 KASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRP 1368
            :.::..:..||.:|.|.:..|:||:.::|:|||||||||
Frog   954 QETMQFLFRHLCKVIECKDSNRMSIQSVAIVFGPTLLRP 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	22/181 (12%)
		PH_BCR_arthropod	851..1037	CDD:270174	36/213 (17%)
		C2	1079..1187	CDD:301316	21/110 (19%)
		RhoGAP	1203..1398	CDD:295372	58/166 (35%)
arhgap27	XP_002933206.3	SH3_ARHGAP27	11..67	CDD:213002	5/15 (33%)
		PHA03247	<91..489	CDD:223021	89/533 (17%)
		WW	434..460	CDD:395320	3/36 (8%)
		PH_ARHGAP9-like	640..753	CDD:270053	33/162 (20%)
		RhoGAP_ARHGAP27_15_12_9	830..1016	CDD:239868	58/166 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030