Protein Alignment RhoGAP1A and Arhgap15

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: NP_722542.2
• Gene: Arhgap15 / 76117
• MGIID: 1923367
• Length: 481
• Species: Mus musculus
• Alignment Length: 607
• Identity: 130/607 - (21%)
• Similarity: 224/607 - (36%)
• Gaps: 191/607 - (31%)

  Fly   789 KKIVSTIVLNLQTEQSLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFL 853
            |:...::..:...:.||.:.:..|:....||:..        :..|:|.|.|...::     |.|
Mouse     3 KRTSCSVQTSTNCDNSLEILNSAHQATGAVQMRI--------KNANSHQDRQSQTKS-----MIL 54

  Fly   854 NQFNVVNQRLPIESN-RNLRRMVRNSFI----------------VELVDGHRKLRHLFLFNDVIA 901
            .....|.:  ||..: ||..:.|....|                .::.||.:|||.
Mouse    55 TDAGKVTE--PISRHRRNHSQHVLKDVIPPLEHPMVEKEGYLQKAKIADGGKKLRK--------- 108

  Fly   902 CAKYKALGRDRIDYELKWFI-PLKDVSIYEEADPAVELKESSPANISQVKRNLRSVRDQLAMEVA 965
                        ::...|.: ..:.:..|:::      |:.:..|: :.:.|:.|| |.....:
Mouse   109 ------------NWSTSWIVLSGRKIEFYKDS------KQQALPNM-KTRHNVESV-DLCGAHI- 152

  Fly   966 NSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSS--DFERTQWIDSILS 1028
                       ::.::.:..:|...:.|.:     ||:       |.|.|  ||....|..:|.:
Mouse   153 -----------EWAKEKSSRKSVFQITTVS-----GNE-------FLLQSDIDFLILDWFQAIKN 194

  Fly  1029 LKQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDLYMGVHGLEGLEQAN 1093
            ...:  ||...:..|||    :..:|:...:|:.|:
Mouse   195 AIDR--LPKNPSCGSLE----LFNLQRSSSSELPSH----------------------------- 224

  Fly  1094 DLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAKERPLLKAKHILK 1158
                |       |..||        .|.|...:|||..|..|.:      :..::..:|::  ||
Mouse   225 ----C-------HIDRK--------EQKPEHRKSFMFRLHHSAS------DTSDKNRVKSR--LK 262

  Fly  1159 LSLSWLTETTQPKSIKLTETLELGCSFRFIPGELFRGSTKPGALFGAKMSQVLKREKRDIPFIIG 1223
            ..:|     .:|....|.|                :|..| ..:||:.:..|.:||...:|:.:.
Mouse   263 KFIS-----RRPSLKTLQE----------------KGLIK-DQIFGSHLHTVCEREHSTVPWFVK 305

  Fly  1224 ACIREVERRGMLEVGCYRVSGSASDLAKL--------KKAFESDAYEAEQLLREVDIHSVTGILK 1280
            .||..||:||:...|.|||||:.:.:.||        |...:...:|        |||.|||.||
Mouse   306 QCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWE--------DIHVVTGALK 362

  Fly  1281 TFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHE 1345
            .|.|||.|.||....:.||.:   |....:.:.:|..:..:.:.||..|..::..:..||.::..
Mouse   363 MFFRELSEPLFPYSFFERFVE---AIKKQDSNEKIETMRSLVKRLPPPNHDTMKILFRHLTKIVA 424

  Fly  1346 KETDNKMSLHNLAMVFGPTLLR 1367
            |.:.|.||..:|.:||||||||
Mouse   425 KASQNLMSTQSLGIVFGPTLLR 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	12/67 (18%)
		PH_BCR_arthropod	851..1037	CDD:270174	34/205 (17%)
		C2	1079..1187	CDD:301316	18/107 (17%)
		RhoGAP	1203..1398	CDD:295372	59/173 (34%)
Arhgap15	NP_722542.2	PH	88..196	CDD:278594	24/160 (15%)
		PH_ARHGAP9-like	89..198	CDD:270053	24/161 (15%)
		RhoGAP_ARHGAP27_15_12_9	285..471	CDD:239868	59/173 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940