Protein Alignment RhoGAP1A and Arhgap42

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: NP_001359492.1
• Gene: Arhgap42 / 71544
• MGIID: 1918794
• Length: 875
• Species: Mus musculus
• Alignment Length: 578
• Identity: 123/578 - (21%)
• Similarity: 208/578 - (35%)
• Gaps: 155/578 - (26%)

  Fly   849 IQMFLNQFNVVNQRLPIESNRNLRRMVRNSFIVELVDGHRKLRHLFLFNDVIACAKYKALGRDRI 913
            |...|.:|    .||.|......||:::|:..| |:....|.|     .:.|..||.   |:.:.
Mouse    83 IAQSLKEF----ARLLIAVEEERRRLIQNANDV-LIAPLEKFR-----KEQIGAAKD---GKKKF 134

  Fly   914 DYELKWFIPLKDVSIYEEADPAVELKESSPANISQVKR--NLRSVRDQLAMEVANSGSGAFRSGD 976
            |.|.:.:..:.|..:                |:|..|:  :|:....|:..|..|    .:.:..
Mouse   135 DKESEKYYSILDKHL----------------NLSAKKKESHLQEADSQIGREHQN----FYEASL 179

  Fly   977 KYRRKLADLE--SQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGAN 1039
            :|..|:.:::  .:.....|.|....|      ..||: ...:|..|   .....||:......|
Mouse   180 EYVFKIQEVQEKKKFEFVEPLLSFLQG------LFTFY-HEGYELAQ---EFAPYKQQLQFNLQN 234

  Fly  1040 TINSLEVTAFIV--AMQKGMKTEMGSYLMRNTNDESLLVGDLY---------------------- 1080
            |.|:.|.|...|  .||: ||:....|   ....:..:.|.||
Mouse   235 TRNNFESTRQEVERLMQR-MKSANQDY---RPPSQWTMEGYLYVQEKRPLGFTWTKHYCTYDKGS 295

  Fly  1081 ----MGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRIL 1141
                |.|..::...:.|.|     |......|:   .|...|.:|...::.|..::|..:...|:
Mouse   296 KMFTMSVSDVKASGKMNGL-----VTGSPEMFK---LKSCIRRKTDSIDKRFCFDIEVVERHGII 352

  Fly  1142 LYEAKERPLLKAKHILKLSLSWLTET-------TQPKSIKLTETLELG-CSFRFIPGELFRGSTK 1198
            ..:|......|.         ||...       |.|..|...|.:.|. ..|.|
Mouse   353 TLQAFSEANRKL---------WLEAMDGKEPIYTLPAIISKKEEMYLNEAGFNF----------- 397

  Fly  1199 PGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEA 1263
                                   :..||:.||.||:..:|.||:.|..|.:.||.....|.....
Mouse   398 -----------------------VRKCIQAVEMRGITILGLYRIGGVNSKVQKLMNTTFSPKSPP 439

  Fly  1264 EQLLREVDIH-----SVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFE 1323
            :.   ::||.     ::|..||.:||.|.|.|.|.:|:.   |...|..:::::.|:..:..:..
Mouse   440 DM---DIDIELWDNKTITSGLKNYLRCLAEPLMTYKLHK---DFIIAVKSDDQNYRVEAVHALVH 498

  Fly  1324 ELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVKQKDPLAA 1381
            :||:.|:..:..::.||::|......|.|::.||.::|||||:|      .|::.:||
Mouse   499 KLPEKNREMLDILIKHLLKVSLHSQQNLMTISNLGVIFGPTLMR------AQEETVAA 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	2/7 (29%)
		PH_BCR_arthropod	851..1037	CDD:270174	37/189 (20%)
		C2	1079..1187	CDD:301316	24/141 (17%)
		RhoGAP	1203..1398	CDD:295372	48/184 (26%)
Arhgap42	NP_001359492.1	BAR_GAP10-like	19..225	CDD:153318	36/184 (20%)
		BAR-PH_GRAF_family	267..376	CDD:269953	19/125 (15%)
		RhoGAP	369..567	CDD:383032	55/228 (24%)
		SH3_GRAF3	821..875	CDD:212999

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1094
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.030