Protein Alignment RhoGAP1A and ARHGAP9

DIOPT Version :9

• Sequence 1: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Sequence 2: NP_001306779.2
• Gene: ARHGAP9 / 64333
• HGNCID: 14130
• Length: 750
• Species: Homo sapiens
• Alignment Length: 1087
• Identity: 215/1087 - (19%)
• Similarity: 342/1087 - (31%)
• Gaps: 480/1087 - (44%)

  Fly   364 ILRQKSSDNLDSKYSAKRKTTPELSKFVNVNNPELMEELGRKMVSKADSLEQTRRNDSSPSGCGS 428
            :||:.:||    .:.|:|...|..|:.:.|....::||                   |.|    |
Human    53 LLRKTNSD----WWLARRLEAPSTSRPIFVPAAYMIEE-------------------SIP----S 90

  Fly   429 LGRTSSTPGRSL-TPGRTGVGASPT---GSLSKTGKL----AMADSSSTSSLERRSCLQAVDADI 485
            ...|:..||:.| |||       |.   |||.:..:.    |.|.|.....|.|:.|
Human    91 QSPTTVIPGQLLWTPG-------PKLFHGSLEELSQALPSRAQASSEQPPPLPRKMC-------- 140

  Fly   486 GTESRESGANQRSVGSKESLTSQGISEVQIKSYE---SVSSLSSESAKAVASQQSAAAGGALAEC 547
                             .|:::..:|...:|.::   |..|||.|...:.||..:|.....::|.
Human   141 -----------------RSVSTDNLSPSLLKPFQEGPSGRSLSQEDLPSEASASTAGPQPLMSEP 188

  Fly   548 EPYYDSVPLDNGDGEYVFIKPGRTGSSSSRDDLSTPGSSILPL-------PNVADPESPGRTSNY 605
            ..|.:.|.|                   .|...|.|.....||       ....||.| ||.. |
Human   189 PVYCNLVDL-------------------RRCPRSPPPGPACPLLQRLDAWEQHLDPNS-GRCF-Y 232

  Fly   606 VNIDFFLQQGIETRSSSLDSDGEYEGPPILRTISHDDQTTTQTTPGAI-------RKNLVSAILV 663
            :|              ||.....::.|         .::.::|.||::       |.|.|    :
Human   233 IN--------------SLTGCKSWKPP---------RRSRSETNPGSMEGTQTLKRNNDV----L 270

  Fly   664 CGNARGAKIRSILSSIIQSETIYVECLNKMMQYKKAIHATLTTSQ---PVIREEEENTIFFKIDE 725
            ...|:|          .:|:|...|.|:.    :.::..:..|||   |.:  :....:...:|:
Human   271 QPQAKG----------FRSDTGTPEPLDP----QGSLSLSQRTSQLDPPAL--QAPRPLPQLLDD 319

  Fly   726 LYDLHTGFLSDLKTIVSHEGGDVLIGEPFRRLAEMFDLYSAFLHNYKNAIETVKKCSANNPQFKK 790
            .:::....|.::..|.  :||        |:|.:.:                       .|
Human   320 PHEVEKSGLLNMTKIA--QGG--------RKLRKNW-----------------------GP---- 347

  Fly   791 IVSTIVLNLQTEQSLTLEDLLHKPVARVQINALVFNDLLRETPNAHPDHQPLRQAQKIIQMFLNQ 855
              |.:||.                     .|:|||   .||.|...|.               :.
Human   348 --SWVVLT---------------------GNSLVF---YREPPPTAPS---------------SG 371

  Fly   856 FNVVNQRLPIESNRNLRRMV----------RNSFIVELVDGHRKLRHLFLF---NDVIACAKYKA 907
            :.....| | ||:.:||...          ||...:..:.||.     ||.   ::....|.::|
Human   372 WGPAGSR-P-ESSVDLRGAALAHGRHLSSRRNVLHIRTIPGHE-----FLLQSDHETELRAWHRA 429

  Fly   908 LGRDRIDYELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNLRSVRDQ--------LAMEV 964
            | |..|:..::|                ||.:..:|..           |||        |.:.:
Human   430 L-RTVIERLVRW----------------VEARREAPTG-----------RDQGSGDRENPLELRL 466

  Fly   965 ANSGSGAFRSGDKYRRKLADLESQLVLATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSL 1029
            :.||.....:|:.     .:.||:|| :.|  :|||.::.::
Human   467 SGSGPAELSAGED-----EEEESELV-SKP--LLRLSSRRSS----------------------- 500

  Fly  1030 KQKCNLPGANTINSLEVTAFIVAMQKGMKTEMGSYLMRNTNDESLLVGDLYMGVHGLEGLEQ--- 1091
                                                                 :.|.||.||
Human   501 -----------------------------------------------------IRGPEGTEQNRV 512

  Fly  1092 ANDLYICVEVDSYGHYFRKATTKKICRSQTPLWNESFMLELEGSQNVRILLYEAKERPLLKAKHI 1156
            .|.|                  |::...:.|                   |...:||.||:.:
Human   513 RNKL------------------KRLIAKRPP-------------------LQSLQERGLLRDQ-- 538

  Fly  1157 LKLSLSWLTETTQPKSIKLTETLELGCSFRFIPGELFRGSTKPGALFGAKMSQVLKREKRDIPFI 1221
                                                         :||.::..:.:||...:|..
Human   539 ---------------------------------------------VFGCQLESLCQREGDTVPSF 558

  Fly  1222 IGACIREVERRGMLEVGCYRVSGSASDLAKLK------KAFESDAYEA--EQLLRE--------- 1269
            :..||..|::||:...|.|||||:.:.:.||:      :|..||....  ||..:|
Human   559 LRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTE 623

  Fly  1270 -VDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASI 1333
             .|||.|||.||.||||||:.|....|.|.|....:...:....::|.||:   ..:|:.|..::
Human   624 WDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELI---GSMPKPNHDTL 685

  Fly  1334 TSILDHLIRVHEKETDNKMSLHNLAMVFGPTLLRPGQTQVKQKDPLA 1380
            ..:|:||.||......|:|:.|||.:||||||.||.|   :..||.|
Human   686 RYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQ---ETSDPAA 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	27/184 (15%)
		PH_BCR_arthropod	851..1037	CDD:270174	36/206 (17%)
		C2	1079..1187	CDD:301316	14/110 (13%)
		RhoGAP	1203..1398	CDD:295372	69/196 (35%)
ARHGAP9	NP_001306779.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..187		17/91 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..319		17/105 (16%)
		Lipid binding	342..345		0/2 (0%)
		Lipid binding	397..399		0/1 (0%)
		Lipid binding	432..669		76/431 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..488		12/58 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940